Highlights ■ Clinical simulations enhance dengue management and  clinical reasoning in undergraduate studies. ■ Mixed methods revealed gaps in physical examinations and  uncertainties in risk classification. ■ Structured debriefing promotes metacognition and critical reflection on errors. ■ Realistic scenarios strengthen empathetic communication  and enhance patient safety. ABSTRACT Objective: To analyze how clinical simulation impacts nursing students’ proficiency in clinical evaluation, decision-making, therapeutic communication, and reporting of dengue fever with warning signs within a primary health care context. Methods: Third-term nursing […]

Highlights ■ TSO500 showed 93.39% sensitivity and high concordance with FoundationOne. ■ Comprehensive Genomic Profiling of 454 tumors revealed the genomic landscape of 57 cancer types. ■ Variants of uncertain significance comprised 57.9% of all genomic events, highlighting challenges in precision oncology. ■ Gene fusions occurred in 13% of cases, with 45.5% classified as variants of uncertain significance. ABSTRACT Background: Precision medicine has transformed cancer management by tailoring treatments to the molecular characteristics of a patient’s tumor. Comprehensive Genomic Profiling […]

Highlights ■ Inflection point agreement was low to moderate amongnon-specialist raters. ■ Thoracolumbar junction showed the lowest inter-observeragreement. ■ Results support the need for protocol standardization and  structured training. ABSTRACT Objective: To assess the intra- and inter-observer reliability of spinal inflection point localization on lateral radiographs of asymptomatic adults using a standardized measurement protocol, given its important role in sagittal alignment analysis and its potential influence on biomechanical interpretation and surgical planning. Methods: This cross-sectional study included 10 adults (five […]

Highlights ■ Brazilian Portuguese translation of SOSGOQ 2.0 scale. ■ First semantic clinical validation of Brazilian SOSGOQ 2.0. ■ Cognitive interviews confirmed clarity and cultural appropriateness. ■ 100% completion with no need for clarification. ■ Ready for large-scale psychometric validation. ABSTRACT Objective: To translate, culturally adapt, and semantically validate the Brazilian Portuguese version of the Spine Oncology Study Group Outcomes Questionnaire 2.0 (SOSGOQ 2.0) through cognitive interviews with patients with spinal metastases. Methods: Following the guidelines of Beaton et al., […]

Highlights ■ Colorectal carcinoma originates from within cancer stem cells of the large intestine. ■ Tissue levels of ALDH1-2 and LGR5 proteins were  associated with greater tumor aggressiveness. ■ Discovery of signaling pathways can improve cancer treatments that control cancer stem cells. ABSTRACT Objective: To investigate the association of CD44, CD133, ALDH1-2, and LGR5 expression with clinicopathological tumor variables. Methods: Twenty-eight adult patients with colorectal carcinoma who underwent curative surgery were included in the study. Paraffin-embedded samples were subjected to […]

Highlights ■ De-escalation of axillary surgery has become a priority in  breast cancer treatment. ■ Factors associated with the decision to omit sentinel lymph node biopsy were collected via questionnaire. ■ Sentinel lymph node biopsy was omitted more often by  private doctors and those holding a doctoral degree. ■ Continuing medical education initiatives are needed to update other groups. ABSTRACT Objective: Considering the increasing number of new breast cancer cases and the morbidity associated with axillary lymph node dissection in […]

Highlights ■ Sugar-sweetened beverages are linked to a poorer inflammatory profile in adolescents. ■ Ultra-processed food intake is associated with a higher leptin/adiponectin ratio. ■ The leptin/adiponectin ratio reflects metabolic risk in adolescent obesity. ■ Dietary quality influences inflammatory hormonal markers. ABSTRACT Objective: To evaluate the relationship between dietary patterns and inflammatory markers in Brazilian adolescents with obesity. Methods: A cross-sectional analysis was conducted among 70 post-pubertal adolescents aged 15–19 years of both sexes who were classified as obese according […]

Highlights ■ Instrument developed to assess medical students’ perceptions of OSCEs. ■ Evidence of strong validity and excellent internal consistency. ■ Formative and summative OSCE modalities were also assessed. ■ Tool supports educational assessment and feedback in medical education. ABSTRACT Objective: To develop, validate, and apply an instrument aimed at assessing medical students’ perceptions of the impact of an Objective Structured Clinical Examination (OSCE), both in its peer-based formative and traditional summative modalities, on clinical learning. Methods: This study used […]

Highlights ■ ACE2 rs2285666 GG genotype increased the risk ofintensive care unit risk in women. ■ TNF rs1800629 A allele was associated with severe COVID-19 and invasive mechanical ventilation. ■ IL1A rs1800587 influenced disease severity and respiratory symptoms. ■ TNF polymorphism was associated with post-COVID, cough and fatigue. ABSTRACT Objective: We evaluated the influence of single-nucleotide polymorphisms in cytokine, renin-angiotensin-aldosterone system, and uromodulin genes on COVID-19 severity and the persistence of symptoms in the post-COVID phase. Methods: Two cross-sectional cohort […]

Highlights ■ Pre-sarcopenic women showed increased cortical excitation during motor tasks. ■ Sarcopenia was associated with slower motor reaction time. ■ EEG revealed central nervous system changes across sarcopenia stages. ■ Pre-sarcopenia may represent a window for early  neuromotor intervention. ABSTRACT Objective: This study aimed to analyze cortical activity during simple motor reaction time tasks in older women with different degrees of sarcopenia. Methods: This cross-sectional, observational, analytical study included 59 women classified into control, pre-sarcopenia, and sarcopenia groups according […]