Highlights ■ This study aimed to evaluate the association between  damage-associated molecular patterns and peripheral hypoperfusion in sepsis. ■ Surviving patients showed better peripheral perfusion than  non-survivors. ■ No significant association was observed between mortality  and serum levels of the evaluated damage-associated  molecular patterns. ■ Damage-associated molecular patterns levels did not differ between patients with reduced or normal peripheral perfusion. ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed […]

Highlights ■ 1,902 microsurgical reconstructions performed in the Brazilian Public Health System (2009-2023). ■ Southern and Southeastern regions concentrate >85% of the procedures. ■ Microsurgery is cost-effective despite its greater complexity. ■ Centralization in São Paulo indicates a need for regional expansion. ABSTRACT Objective: To evaluate the national distribution and cost-effectiveness of oncologic microsurgical reconstructions performed within the Brazilian Public Health System over a 14-year period. Methods: A retrospective analysis of DATASUS data was conducted using three procedure codes related […]

Highlights ■ Training markedly improves theoretical knowledge and performance in cardiopulmonary resuscitation and foreign body airway obstruction management. ■ Significant knowledge and skills, particularly in the Heimlich maneuver, remain after 6 months. ■ The objective structured clinical examination is a practical  and reliable method to evaluate first-aid skills in schools. ABSTRACT Objective: To assess the knowledge and performance of high school students in cardiopulmonary resuscitation and foreign body airway obstruction management using an objective structured clinical examination. Methods: An interventional […]

Highlights ■ First Brazilian Portuguese version of the LT-QOL questionnaire. ■ Translation and cross-cultural adaptation followed COSMIN recommendations. ■ Strong internal consistency (Cronbach’s alpha=0.86). ■ Excellent intra-rater reliability (ICC=0.93). ■ High convergent validity with SF-36 and good correlation  with SGRQ. ■ Provides a disease-specific tool for assessing quality of life after lung transplantation in Brazil. ■ Supports future clinical monitoring and research on transplant outcomes. ABSTRACT Objective: To translate, cross-culturally adapt, and validate the Lung Transplant Quality of Life questionnaire […]

Highlights ■ SR-B1 knockdown inhibits breast cancer cell proliferation and migration. ■ Silencing SR-B1 promotes apoptosis in breast cancer cells. ■ PI3K/AKT pathway activity decreases after SR-B1 knockdown. ■ Cyclin D1 and P70 are downregulated following SR-B1 silencing. ABSTRACT Background: The role of scavenger receptor class B type 1 (SR-B1) in breast cancer remains largely unknown. Objective: This study aimed to investigate the effects of SR-B1 on breast cancer cell proliferation, migration, and invasion and to elucidate the underlying mechanisms. […]

Highlights ■ The 35 navigation metrics by AONN+ were cross-culturally  adapted. ■ Navigation metrics support the standardization of evaluating navigation results for programs in Brazil. ABSTRACT Objective: To perform the translation and cross-cultural adaptation into Brazilian Portuguese of the 35 navigation metrics developed by the Academy of Oncology Nurse & Patient Navigators (AONN+). Methods: This study employed a methodological approach for cross-cultural adaptation. Following authorization from the authors of the original version of the 35 metrics for evaluating navigation programs, […]

Highlights ■ EDAcw objectively quantifies sweating in patients with hyperhidrosis. ■ Sympathectomy significantly reduced EDAcw and  improved the quality of life. ■ The hands showed a 97% reduction in electrodermal activity postoperatively. ■ EDAcw is a reliable non-invasive tool for clinical evaluation and follow-up. ABSTRACT Objective: To analyze continuous exosomatic electrodermal activity (EDA) without external stimuli (EDAcw) in patients with primary hyperhidrosis before and after sympathectomy. Methods: This prospective study included 28 participants, categorized into two groups. The first group […]

Highlights ■ Immunohistochemistry distinguishes Warthin-like mucoepidermoid carcinoma from metaplastic Warthin tumor. ■ CK7, mitochondrial patterns, and double-layer epithelium suggest metaplastic Warthin tumor. ■ Basal CK14, CK5/6, and p63 distinguish metaplastic Warthin tumor from Warthin-like mucoepidermoid carcinoma. ABSTRACT Objective: This study aimed to analyze the clinicopathological and immunohistochemical profiles of unconventional Warthin tumors and mucoepidermoid carcinomas. Methods: Eleven low-grade salivary gland tumors with Warthin-like features were analyzed. Group A (n=6) showed a double-layered oncocytic epithelium in less than 50% of the […]

Highlights ■ Oxidative stress markers are associated with the intensity and consequences of ischemia-reperfusion injury during deceased-donor kidney transplantation. ■ The donor’s serum hydrogen peroxide level achieved 85.7% sensitivity and a 91.7% negative predictive value for  detecting delayed graft function lasting more than one week. ■ Donor H2O2 ≤14μM is suggested to dichotomize risk for delayed graft function lasting longer than a week. ■ This study provides pivotal information on the use of oxidative stress markers to identify patients at […]

Highlights ■ Forty-four percent of mothers of children with autism spectrum disorder have poor sleep quality. ■ Seventy percent did not meet the recommended 7-9 hours of sleep. ■ Demographic, child-related, and clinical data were associated with sleep problems. ABSTRACT Objective: To analyze the factors associated with sleep quality and duration in mothers of children with autism spectrum disorder. Methods: A cross-sectional study was conducted with 595 mothers (37±7yrs) of children and adolescents with autism spectrum disorder (8.1±3.1yrs). The assessed […]