521 results

Effective vancomycin concentrations in children: a cross-sectional study

Geisa Cristina da Silva Alves ORCID logo , Farah Maria Drumond Chequer ORCID logo , Cristina Sanches ORCID logo

DOI: 10.31744/einstein_journal/2019AO4396

ABSTRACT Objective Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. Methods This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour […]

Risk factors associated with in-hospital falls reported to the Patient Safety Commitee of a teaching hospital

Adriane Kênia Moreira Silva ORCID logo , Dayane Carlos Mota da Costa ORCID logo , Adriano Max Moreira Reis ORCID logo

DOI: 10.31744/einstein_journal/2019AO4432

ABSTRACT Objective To investigate the use of fall-risk-increasing drugs among patients with falls reported to the Patient Safety Office of a hospital, and to identify the factors associated with high risk for fall. Methods A cross-sectional study, carried out in a teaching hospital. The study population was the universe of fall reports received by the Patient Safety Office. The dependent variable was a high risk for falls. The Medication Fall Risk Score was used to measure fall risk. Descriptive, univariate […]

Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration

Renato Carneiro de Freitas Chaves ORCID logo , Philipe Franco do Amaral Tafner ORCID logo , Felipe Ko Chen ORCID logo , Letícia Bagatini Meneghini ORCID logo , Thiago Domingos Corrêa ORCID logo , Roberto Rabello Filho ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4439

ABSTRACT Objective To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury. Methods A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Vascular occlusion test was performed on the forearm to be submitted to near-infrared spectroscopy […]

Evaluation of the quality of Primary Health Care services for children: reflections on the feasibility of using the Brazilian version of the Primary Care Assessment Tool as a routine assessment tool

Liz Ponnet ORCID logo , Sara Willems ORCID logo , Veerle Vyncke ORCID logo , Aylene Emilia Moraes Bousquat ORCID logo , Ana Luiza d’Ávila Viana ORCID logo , Guilherme Arantes Mello ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4333

ABSTRACT Objective To assess the quality of the Primary Health Care services provided to children and the feasibility of using the Brazilian version of Primary Care Assessment Tool (PCAT-Brazil) as a routine quality assessment tool. Methods A cross-sectional study was carried out in Joanópolis, a small rural town in the State of São Paulo (SP), Brazil. Seven health professionals and 502 caretakers of children using the public health center were interviewed using the PCAT-Brazil, collecting data on the core and […]

Assessing how emergency and trauma ultrasonography is taught to medical students

José Cruvinel Neto ORCID logo , Vinicius Rinaldi Vieira Marcondes ORCID logo , Marcelo Augusto Fontenelle Ribeiro Junior ORCID logo

DOI: 10.31744/einstein_journal/2019AO4469

ABSTRACT Objective To evaluate a method aimed at teaching ultrasound techniques to medical students in emergency settings. Methods A prospective study conducted with 66 sixth-year undergraduate medical students. Students participated in theory and practicing sessions with a 5-hour load; knowledge acquisition was assessed through pre- and post-course and 90-day tests. A questionnaire were distributed to the students after course completion for theoretical and practical knowledge assessment. Results Average pre-test grade in theoretical content evaluation was 4.9, compared to 7.6 right […]

Allele and haplotype frequencies of human platelet and leukocyte antigens in platelet donors

Valeria de Freitas Dutra ORCID logo , Carolina Bonet Bub ORCID logo , Thiago Henrique Costa ORCID logo , Leandro Dinalli Santos ORCID logo , Eduardo Peres Bastos ORCID logo , Maria Giselda Aravechia ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4477

ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets between January 2011 and December 2014. Microarray genotyping was performed using a BeadChip microarray. Medium resolution typing of the human leukocyte antigen at loci A and B was carried out using sequence-specific […]

Streptococcus mutans detection in saliva and colostrum samples

Camilla Beatriz da Silva ORCID logo , Marcelly Milhomem Mendes ORCID logo , Bárbara Rocha Rodrigues ORCID logo , Thiago Lima Pereira ORCID logo , Denise Bertulucci Rocha Rodrigues ORCID logo , Virmondes Rodrigues Junior ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4515

ABSTRACT Objective To detect Streptococcus mutans in colostrum and saliva of neonates and compare with its detection in saliva of mothers. Methods Forty-three healthy women, full-term gestations with no complications, submitted to elective Cesarean section, and their newborns were included in the study. Samples were investigated by polymerase chain reaction to detect S. mutans in genetic material from the samples. Results Approximately 16% of colostrum samples showed S. mutans , but not correlated with the presence of the bacteria in […]

Association between respiratory capacity, quality of life and cognitive function in elderly individuals

Rayana de Oliveira Costa ORCID logo , Raphael Mendes Ritti-Dias ORCID logo , Gabriel Grizzo Cucato ORCID logo , Maysa Seabra Cendoroglo ORCID logo , Fabio Nasri ORCID logo , Maria Luiza Monteiro Costa ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4337

ABSTRACT Objective To investigate associations between respiratory capacity, quality of life and cognitive function in elderly individuals. Methods The sample included 386 elderly individuals (232 women). Respiratory capacity assessment was based on maximal expiratory pressure measured at peak expiratory flow. Subjects were classified according to peak expiratory flow values adjusted for sex, age and height of individuals with normal (peak expiratory flow curve 60%) or reduced (peak expiratory flow curve < 60%) respiratory capacity. The World Health Organization Quality of [...]

Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer

Luana Carolina Ferreira Fiuza Silva ORCID logo , Lilian Silva Martins de Arruda ORCID logo , Waldec Jorge David Filho ORCID logo , Felipe José Silva Melo Cruz ORCID logo , Damila Cristina Trufelli ORCID logo , Auro del Giglio ORCID logo

DOI: 10.31744/einstein_journal/2019AO3434

ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type […]

Prevalence of G6PD deficiency and molecular characterization of G202A, A376G and C563T polymorphisms in newborns in Southeastern Brazil

Lucas Luís Meigre Dias Pereira ORCID logo , Cristina Augusta Bravin ORCID logo , Terezinha Sarquis Cintra ORCID logo , Wélida Santos Portela Cassa ORCID logo , Thainá Altoé Santos ORCID logo , Armando Fonseca ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4436

ABSTRACT Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patients identified as deficient were submitted to molecular analysis quantitative real-time polymerase chain reaction – (qPCR) to investigate the presence of variants associated with the deficiency. Results The total prevalence of G6PD deficient was 2.5%. Of the 25 samples identified […]

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