17 results

Prevalence of G6PD deficiency and molecular characterization of G202A, A376G and C563T polymorphisms in newborns in Southeastern Brazil

Lucas Luís Meigre Dias Pereira ORCID logo , Cristina Augusta Bravin ORCID logo , Terezinha Sarquis Cintra ORCID logo , Wélida Santos Portela Cassa ORCID logo , Thainá Altoé Santos ORCID logo , Armando Fonseca ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4436

ABSTRACT Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patients identified as deficient were submitted to molecular analysis quantitative real-time polymerase chain reaction – (qPCR) to investigate the presence of variants associated with the deficiency. Results The total prevalence of G6PD deficient was 2.5%. Of the 25 samples identified […]

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Flávia Mylla de Sousa Reis, Renata Rodrigues de Oliveira Castelo Branco, Amanda Mota Conceição, Letícia Paula Benvindo Trajano, José Felipe Pinheiro do Nascimento Vieira, Pablo Ricardo Barbosa Ferreira, [...]

DOI: 10.1590/S1679-45082018AO4150

ABSTRACT Objective To evaluate the incidence of variant hemoglobins in different health regions. Methods A descriptive, observational, and cross-sectional study with a quantitative approach based on secondary data in the internal records of the neonatal screening service – Laboratório Central de Saúde Pública do Estado do Piauí (PI, Brazil). The variables related to sex, ethnicity and positive diagnosis for variant hemoglobins were analyzed, with further population distribution of hemoglobinopathies among the macroregions of the state. Results A total of 69,180 […]

Perinatal ischemic stroke: a five-year retrospective study in a level-III maternity

Virgínia Machado, Sónia Pimentel, Filomena Pinto, José Nona

DOI: 10.1590/S1679-45082015AO3056

ObjectiveTo study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke.MethodsData was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011.ResultsThere were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis. We estimated an incidence of arterial ischemic stroke of 1.6/5,000 births and of cerebral venous sinus thrombosis of 7.2/100,000 births. […]

A rare case of perineal hamartoma associated with cryptorchidism and imperforate anus: case report

Kleiton Gabriel Ribeiro Yamaçake, Amilcar Martins Giron, Uenis Tannuri, Miguel Srougi

DOI: 10.1590/S1679-45082014RC2746

A full-term male neonate with anorectal anomaly and external perineal anomalies was referred to our service. Physical examination showed an epithelized perineal mass with cutaneous orifices, which had urine fistulization, hipotrofic perineal musculature, bilateral congenital clubfoot, hipospadic urethra, criptorquidy bilateral with nonpalpable testis and imperforate anus. A colostomy was constructed immediately after birth. The child underwent excision of perineal mass, bilateral orchidopexy, Duplay neourethroplasty and coloanal anastomosis at 3 months of age. The histopathological examination of the perineal mass revealed […]

Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report

Fabiana Mendes Conti, Sergio Hibner, Thiago Henrique Costa, Marcia Regina Dezan, Maria Giselda Aravechia, Ricardo Antonio D’Almeida Pereira, [...]

DOI: 10.1590/S1679-45082014RC2729

Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia […]

Influence of assessment site in measuring transcutaneous bilirubin

Cristiane Maria da Conceição, Maria Fernanda Pellegrino da Silva Dornaus, Maria Aparecida Portella, Alice D’Agostini Deutsch, Celso Moura Rebello

DOI: 10.1590/S1679-45082014AO2711

Objective:To investigate the influence of the site of measurement of transcutaneous bilirubin (forehead or sternum) in reproducibility of results as compared to plasma bilirubin.Methods: A cohort study including 58 term newborns with no hemolytic disease. Transcutaneous measurements were performed on the forehead (halfway between the headline and the glabella, from the left toward the right side, making consecutive determinations, one-centimeter apart) and the sternum (five measurements, from the suprasternal notch to the xiphoid process with consecutive determinations, one-centimeter apart) using […]

Influenza vaccine in pregnant women: immunization coverage and associated factors

Renato de Ávila Kfouri, Rosana Richtmann

DOI: 10.1590/S1679-45082013000100010

OBJECTIVES:To describe the immunization coverage of the influenza vaccine for pregnant women, and factors associated to vaccination compliance.METHODS:This is a prospective, descriptive study including 300 women who had just given birth at Hospital and Maternity Santa Joana in Sao Paulo, Brazil. Data were collected through a pre-tested questionnaire applied by a trained evaluator during October 2010.RESULTS:The mean age of mothers was 30.5 years; 231 (77%) were married; 164 (54.7%) were primigravidas; 192 (64%) had higher education; and 240 (80%) were […]

Association of newborn diseases with weight/length ratio and the adequacy of weight for gestational age

José Ricardo Dias Bertagnon, Marcos da Cruz Rocha, Gabriela Alba Kuraim, Rosângela Guidara, Neil Ferreira Novo

DOI: 10.1590/s1679-45082011ao2086

ABSTRACTObjective:To compare the frequencies of newborn diseases in those newborns classified according to a weight/length rate and those classified by the adequacy weight for gestational age.Methods:A retrospective cross-sectional study by record assessment was carried out enclosing all the live newborns at Hospital Geral do Grajaú, from September to December, 2009 (n =577) classified according to the rate weight/length and also to the adequacy weight for gestational age. The 10 and 90 percentiles of the weight/length distribution, now designated as “indices” […]

Measurement of the palpebral fissure and the vermilion border of the upper lip in newborns with gestational ages of 25 to 43 weeks

Maria dos Anjos Mesquita, Conceição Aparecida de Mattos Segre

DOI: 10.1590/s1679-45082011ao2097

ABSTRACTObjective:To prepare percentile curves for measurements of palpebral fissure and the greatest width of the vermilion border of the upper lip in newborns at a public maternity ward in the City of São Paulo.Methods:A descriptive cross-sectional study was carried out from August 2006 to January 2008. In the first 24 to 72 hours of life, the palpebral fissure and the greatest width of the vermilion border of the upper lip were measured in 1,964 newborns with gestational ages from 25 […]

Cardiac tamponade due to peripheral inserted central catheter in newborn

Maria Fernanda Pellegrino da Silva Dornaus, Maria Aparecida Portella, Arno Norberto Warth, Rosana Aparecida Lacava Martins, Mauricio Magalhães, Alice D'Agostini Deutsch

DOI: 10.1590/s1679-45082011rc1885

ABSTRACTThis article reports the case of an adverse event of cardiac tamponade associated with central catheter peripheral insertion in a premature newborn. The approach was pericardial puncture, which reversed the cardiorespiratory arrest. The newborn showed good clinical progress and was discharged from hospital with no complications associated with the event.

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