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Recent Articles

Retinal exams requested at Primary Care Unit: indications, results and alternative strategies of evaluation

Fernando Korn Malerbi ORCID logo , Adriano Biondi Monteiro Carneiro ORCID logo , Marcelo Katz ORCID logo , Claudio Luiz Lottenberg ORCID logo

DOI: 10.31744/einstein_journal/2020GS4913

ABSTRACT Objective To evaluate indications, results and strategy of retinal exams requested at Primary Care Units. Methods A retrospective study that analyzed the indications and results of retinal exams, in the modalities clinical dilated fundus exams and color fundus photographs. In the following situations, patients were considered eligible for color fundus photographs if visual acuity was normal and ocular symptoms were absent: diabetes mellitus and/or hypertension, in use of drugs with potential retinal toxicity, diagnosis or suspicion of glaucoma, stable […]

The rare holley antibody associated with a severe hemolytic transfusion reaction: the importance of this antibody identification to find a compatible blood unit

Leandro Dinalli Santos ORCID logo , Carolina Bonet Bub ORCID logo , Maria Giselda Aravechia ORCID logo , Eduardo Peres Bastos ORCID logo , Jose Mauro Kutner ORCID logo , Lilian Castilho ORCID logo

DOI: 10.31744/einstein_journal/2020RC4582

ABSTRACT The correct identification of erythrocyte antibodies is fundamental for the searching for compatible blood and haemolytic transfusion reactions prevention. Antibodies against antigens of high prevalence are difficult to identify because of the rarity of their occurrence and unavailability of negative red cells for confirmation. We report a case of 46-years-old woman, diagnosed with hemoglobinopathy, and who had symptomatic fall in hemoglobin levels (5.3g/dL) after blood transfusion suggestive of transfusion reaction. The patient’s blood type was O RhD-positive. Irregular antibody […]

Posterior quadratus lumborum block for primary total hip arthroplasty analgesia: a comparative study

Promil Kukreja ORCID logo , Lisa MacBeth ORCID logo , William Potter ORCID logo , Katherine Buddemeyer ORCID logo , Henry DeBell ORCID logo , Hesham Elsharkawy ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4905

ABSTRACT Objective To compare analgesia and opioid consumption for patients undergoing primary total hip arthroplasty with preoperative posterior quadratus lumborum block with patients who did not receive quadratus lumborum block. Methods The medical records of patients undergoing unilateral total hip arthroplasty between January 1st, 2017 and March 31, 2018 were reviewed, and 238 patients were included in the study. The primary outcome was postoperative opioid consumption in the first 24 postoperative hours. Secondary outcomes were intraoperative, post anesthesia care unit, […]

Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease

Emanuel Almeida Moreira de Oliveira ORCID logo , Kenia de Assis Boy ORCID logo , Ana Paula Pinho Santos ORCID logo , Carla da Silva Machado ORCID logo , Cibele Velloso-Rodrigues ORCID logo , Pâmela Souza Almeida Silva Gerheim ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4742

ABSTRACT Objective To evaluate the induction of DNA damage in peripheral blood mononuclear cells of patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea. Methods The study subjects were divided into two groups: one group of 22 patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea, and a Control Group composed of 24 patients with sickle cell disease who were not treated with hydroxyurea. Peripheral blood samples were submitted to peripheral blood mononuclear cell […]

Endobronchial ultrasound: a minimally invasive technology to assist diagnosis of thoracic diseases

Altair da Silva Costa Jr ORCID logo , Addy Lidvina Mejia Palomino ORCID logo , Iunis Suzuki ORCID logo , Paulo Rogerio Scordamaglio ORCID logo , Marcelo Gervilla Gregorio ORCID logo , Marcia Jacomelli ORCID logo

DOI: 10.31744/einstein_journal/2019MD4921

ABSTRACT The endobronchial ultrasound is a minimally invasive technique that simultaneously associates ultrasound and bronchoscopy, to visualize lung nodule or masses, airway wall, and structures adjacent to the tracheobronchial tree. Endobronchial ultrasound has been incorporated into clinical practice all over the world because of its low risk and high diagnostic yield in neoplastic and non-neoplastic disease.

Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review

Carina de Sousa Santos ORCID logo , Fabrício Expedito Lopes Nascimento ORCID logo

DOI: 10.31744/einstein_journal/2019RB4898

ABSTRACT Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for […]

Hypertensive crisis: clinical characteristics of patients with hypertensive urgency, emergency and pseudocrisis at a public emergency department

Angela Maria Geraldo Pierin ORCID logo , Carime Farah Flórido ORCID logo , Juliano dos Santos ORCID logo

DOI: 10.31744/einstein_journal/2019AO4685

ABSTRACT Objective: To assess patients with hypertensive crisis, classified as urgency, emergency or pseudocrisis, and identify the associated variables. Methods: We evaluated a total of 508 patients (57% women; 56.3±13.8 years old) with hypertensive crisis (diastolic blood pressure of 120mmHg), aged 18 years or over, seen at the emergency department of a public general hospital. Results: The prevalence of hypertensive crises was 6/1,000; in that, 71.7% presented hypertensive urgency, 19.1% hypertensive emergency, and 9.2% hypertensive pseudocrisis. In the multinominal logistic […]

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Luciano Miller Reis Rodrigues ORCID logo , Lilian Zerbinatti de Oliveira ORCID logo , Mariane de Barros Ribeiro da Silva ORCID logo , Camila de Melo Accardo ORCID logo , Adriana Braz Del Giglio ORCID logo , Maria Aparecida da Silva Pinhal ORCID logo

DOI: 10.31744/einstein_journal/2019AO4637

ABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration […]

Evaluation of platelet concentrate prescription in pediatric patients at a tertiary care hospital

Camila Augusta Victorino ORCID logo , João Carlos Pina Faria ORCID logo , Fabíola Isabel Suano-Souza ORCID logo , Roseli Oselka Saccardo Sarni ORCID logo

DOI: 10.31744/einstein_journal/2019AO4720

ABSTRACT Objective: To verify the adequacy of platelet concentrate prescription by pediatricians in different pediatric sectors of a general hospital. Methods: A cross-sectional study evaluating 218/227 platelet concentrate records in children and adolescents (zero to 13 years old), from January 2007 to April 2015, by the pediatricians of the emergency room, sick bay and intensive care unit. The requisitions were excluded in patients with hematological diseases and those without the number of platelets. Results: Children under 12 months received 98 […]