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Recent Articles

Evaluation and reconditioning of donor organs for transplantation through ex vivo lung perfusion

Luis Gustavo Abdalla ORCID logo , Karina Andrighetti de Oliveira-Braga ORCID logo , Lucas Matos Fernandes ORCID logo , Marcos Naoyuki Samano ORCID logo , Paula Refinetti Camerini ORCID logo , Paulo Manuel Pêgo-Fernandes ORCID logo

DOI: 10.31744/einstein_journal/2019AO4288

ABSTRACT Objective: To assess the feasibility and impact of ex vivo lung perfusion with hyperoncotic solution (Steen Solution™) in the utilization of these organs in Brazil. Methods: In this prospective study, we subjected five lungs considered to be high risk for transplantation to 4 hours of ex vivo lung perfusion, with evaluation of oxygenation capacity. High-risk donor lungs were defined by specific criteria, including inflammatory infiltrates, pulmonary edema and partial pressure of arterial oxygen less than 300mmHg (inspired oxygen fraction […]

Risk profile for antiangiogenic agent-related osteonecrosis of the jaws

Raquel D’Aquino Garcia Caminha ORCID logo , Gabriela Moura Chicrala ORCID logo , Luiz Alberto Valente Soares Júnior ORCID logo , Paulo Sérgio da Silva Santos ORCID logo

DOI: 10.31744/einstein_journal/2019RW4628

ABSTRACT To establish the profile of patients who developed antiangiogenic agent-related osteonecrosis of the jaws, and identify the treatments currently used in dental management. We searched the PubMed®/Medline® and Scopus databases using the words “osteonecrosis AND antiangiogenic therapy”, with the following inclusion criteria: articles published in English, case reports, available online, and for an unlimited period. Of the 209 articles retrieved, 18 were selected, for a total of 19 case reports, since one article included two cases that met the […]

Comparative study between monoexponential and biexponential diffusion weighted imaging sequences in multiparametric prostate magnetic resonance imaging

Victor Martins Tonso ORCID logo , Fernando Ide Yamauchi ORCID logo , Thais Caldara Mussi ORCID logo , Eduardo Figueiredo ORCID logo , Ronaldo Hueb Baroni ORCID logo

DOI: 10.31744/einstein_journal/2019AO4615

ABSTRACT Objective: To compare qualitatively and quantitatively, in terms of image quality, a new biexponential diffusion sequence protocol with the standard monoexponential diffusion protocol on multiparametric prostate magnetic resonance imaging. Methods: This study had a prospective data collection and cross-sectional analysis. Between August and November 2017, a total of 70 patients who underwent multiparametric prostate magnetic resonance imaging due to clinical suspicion of prostatic neoplasia were recruited. The images obtained were evaluated by two independent readers regarding subjective/qualitative criteria (six […]

Peri-prosthetic infection in the postoperative period of endovascular abdominal aorta aneurysm repair: treatment by percutaneous drainage

Diego Lima Nava Martins ORCID logo , Priscila Mina Falsarella ORCID logo , Antonio Rahal Junior ORCID logo , Rodrigo Gobbo Garcia ORCID logo

DOI: 10.31744/einstein_journal/2019RC4668

ABSTRACT Endovascular aneurysm repair is an established technique for treating many infrarenal aortic aneurysms. Infection is one of the most serious complications of this technique, and although percutaneous treatment has been well established for intra-abdominal collections, its use to treat peri-prosthetic fluid collections has not been well determined. In this article we describe a small series of three patients who were treated with percutaneous drainage, with good clinical and imaging responses. Percutaneous drainage is a safe, effective and minimally invasive […]

Dupilumab in the treatment of severe atopic dermatitis refractory to systemic immunosuppression: case report

Mara Huffenbaecher Giavina-Bianchi ORCID logo , Pedro Giavina-Bianchi ORCID logo , Luiz Vicente Rizzo ORCID logo

DOI: 10.31744/einstein_journal/2019RC4599

ABSTRACT Case report of a patient with severe atopic dermatitis who showed a good response to dupilumab. She had already used two immunosuppressive agents, cyclosporine A and mycophenolate mofetil, for the treatment of atopic dermatitis with no proper control of the disease. She had also been taking all measures to control severe cases of the disease: bath and environmental controls, topical potent corticosteroids and emollients. She presented constant pruritus and skin lesions, frequent skin infections e poor quality of life. […]

Medication errors in emergency departments: is electronic medical record an effective barrier?

Marina Vaidotas ORCID logo , Paula Kiyomi Onaga Yokota ORCID logo , Neila Maria Marques Negrini ORCID logo , Dafne Braga Diamante Leiderman ORCID logo , Valéria Pinheiro de Souza ORCID logo , Oscar Fernando Pavão dos Santos ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019GS4282

ABSTRACT Objective: To compare medication errors in two emergency departments with electronic medical record, to two departments that had conventional handwritten records at the same organization. Methods: A cross-sectional, retrospective, descriptive, comparative study of medication errors and their classification, according to the National Coordinating Council for Medication Error Reporting and Prevention, associated with the use of electronic and conventional medical records, in emergency departments of the same organization, during one year. Results: There were 88 events per million opportunities in […]

Scientific integrity 2.0: misconduct. Let’s prevent, not punish!

Anna Carla Goldberg ORCID logo , Oscar Fernando Pavão dos Santos ORCID logo , Celso Moura Rebello ORCID logo , Jacyr Pasternak ORCID logo

DOI: 10.31744/einstein_journal/2019ED5064

The growing complexity of modern, innovative research has brought up important issues concerning research compliance and responsible conduct of research. The scope of items to be managed have expanded to include a great variety of issues, ranging from authorship, plagiarism, data management, confidentiality, patent rights, conflicts of interest to ethical conduct, animal well-being and social aspects of ongoing research.() All these factors have increasingly burdened the daily routine of wet laboratories, clinical research centers, and animal facilities involved in scientific […]

Implementing technologies to prevent medication errors at a high-complexity hospital: analysis of cost and results

Renata Prado Bereta Vilela ORCID logo , Marli de Carvalho Jericó ORCID logo

DOI: 10.31744/einstein_journal/2019GS4621

ABSTRACT Objective: To calculate the cost and assess the results on implementing technological resources that can prevent medication errors. Methods: A retrospective, descriptive-exploratory, quantitative study (2007-2015), in the model of case study at a hospital in the Brazilian Southeastern Region. The direct cost of each technology was calculated in the drug chain. Technological efficacy was observed from the reported series of the indicator incidence of medication errors. Results: Thirteen technologies were identified to prevent medication errors. The average cost of […]

Chronic treatment with hydroalcoholic extract of Plathymenia reticulata promotes islet hyperplasia and improves glycemic control in diabetic rats

Fernanda Oliveira Magalhães ORCID logo , Elizabeth Uber-Bucek ORCID logo , Patricia Ibler Bernardo Ceron ORCID logo , Thiago Fellipe Name ORCID logo , Humberto Eustáquio Coelho ORCID logo , Claudio Henrique Gonçalves Barbosa ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4635

ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were allocated to one of 8 groups, as follows: diabetic and control rats treated with water, diabetic and control rats treated with 100mg/kg or 200mg/kg of plant extract, and diabetic and control rats treated with glyburide. Treatment consisted of […]