7 results

Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer

Luana Carolina Ferreira Fiuza Silva ORCID logo , Lilian Silva Martins de Arruda ORCID logo , Waldec Jorge David Filho ORCID logo , Felipe José Silva Melo Cruz ORCID logo , Damila Cristina Trufelli ORCID logo , Auro del Giglio ORCID logo

DOI: 10.31744/einstein_journal/2019AO3434

ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type […]

Oral and oropharyngeal cancer: epidemiology and survival analysis

Juliana da Silva Moro, Marília Cunha Maroneze, Thiago Machado Ardenghi, Luisa Machado Barin, Cristiane Cademartori Danesi

DOI: 10.1590/S1679-45082018AO4248

ABSTRACT Objective To evaluate the epidemiological profile and survival rate of oral and oropharyngeal cancer patients seen at a university hospital. Methods A cross-sectional study was carried out by means of the pathological reports of patients with oral and oropharyngeal cancer, seen at a university hospital of the Southern Region, between January 2004 and December 2014. Information was collected on patients and tumors. The mortality rate was gathered from the patient death registry in the Mortality Information System. Data were […]

Specificities of presentation of Crohn’s disease in childhood

Bruna Karoline Pinheiro França Protásio, Camila Maria Pinheiro Machado Martins Barbosa, Clarice Blaj Neufeld, Leandro Dimasi Buck, Lygia de Souza Lima Laund, Mauro Sergio Toporovski, [...]

DOI: 10.1590/S1679-45082017RC4070

ABSTRACT The incidence of inflammatory bowel disease in the pediatric population has increased in the last years. The most common form of inflammatory bowel disease is Crohn’s disease and, according to its form and age of presentation, it is possible to predict the evolution of the disease.

Clinical and laboratory characteristics associated with referral of hospitalized elderly to palliative care

Suelen Pereira Arcanjo, Luis Alberto Saporetti, José Antonio Esper Curiati, Wilson Jacob-Filho, Thiago Junqueira Avelino-Silva

DOI: 10.1590/S1679-45082018AO4092

ABSTRACT Objective To investigate clinical and laboratory characteristics associated with referral of acutely ill older adults to exclusive palliative care. Methods A retrospective cohort study based on 572 admissions of acutely ill patients aged 60 years or over to a university hospital located in São Paulo, Brazil, from 2009 to 2013. The primary outcome was the clinical indication for exclusive palliative care. Comprehensive geriatric assessments were used to measure target predictors, such as sociodemographic, clinical, cognitive, functional and laboratory data. […]

Genetic polymorphisms and non-small-cell lung cancer: future paradigms

Ramon Andrade Bezerra de Mello

DOI: 10.1590/S1679-45082014RB2906

This article addresses some current issues about genetic polymorphisms studied in the non-small-cell lung cancer translational field. Furthermore, it discusses about new potential biomarkers regarding lung cancer risk and prognosis.

Decompensated heart failure

Sandrigo Mangini, Philippe Vieira Pires, Fabiana Goulart Marcondes Braga, Fernando Bacal

DOI: 10.1590/S1679-45082013000300022

Heart failure is a disease with high incidence and prevalence in the population. The costs with hospitalization for decompensated heart failure reach approximately 60% of the total cost with heart failure treatment, and mortality during hospitalization varies according to the studied population, and could achieve values of 10%. In patients with decompensated heart failure, history and physical examination are of great value for the diagnosis of the syndrome, and also can help the physician to identify the beginning of symptoms, […]

Microcirculatory assessment in daily clinical practice – not yet ready but not too far!

Diamantino Ribeiro Salgado, Raphaël Favory, Daniel De Backer

DOI: 10.1590/s1679-45082010rw1311

ABSTRACTShock is characterized by an alteration in tissue perfusion that may lead to tissue hypoxia. Recent guidelines recommend aggressive and early resuscitation therapy, but mortality rate is still unacceptably high. Unfortunately, traditional clinical surrogates used to guide resuscitation therapy poorly correlate with microcirculatory blood flow, a key determinant of tissue perfusion. New techniques that directly assess microcirculatory perfusion at the bedside have emerged as a complement to traditional macrohemodynamic parameters. These techniques have been supported by several studies showing microcirculatory […]