12 results

Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes

Amanda Soares Alves ORCID logo , Valquiria Bueno ORCID logo

DOI: 10.31744/einstein_journal/2019RB4733

ABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of naïve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose […]

Comparison of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in normoglycemic and hyperglycemic subjects

Brena Barros Mendes ORCID logo , Anniely Carvalho Rebouças Oliveira ORCID logo , Keila Correia de Alcântara ORCID logo

DOI: 10.31744/einstein_journal/2019AO4403

ABSTRACT Objective: To compare the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as possible parameters of systemic inflammation in hyperglycemic and normoglycemic subjects. Methods: A retrospective, cross-sectional study of data collected from patients tested for fasting blood glucose, glycated hemoglobin (HbA1c) and blood count on the same day, between July and December 2016. Patients were divided into hyperglycemic and normoglycemic, and matched by age and sex. The data were analyzed using Epi Info™, version 7.2.1.0, for the Windows® platform. Results: We enrolled 278 […]

Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome

Carolina Vicaria Rodrigues D’Aurea, Bruno Gion de Andrade Cerazi, Antonio Gabriele Laurinavicius, Carolina Castro Porto Silva Janovsky, Raquel Dilguerian de Oliveira Conceição, Raul D Santos, [...]

DOI: 10.1590/S1679-45082017AO3900

ABSTRACT Objective To investigate the inter-relation between high sensitivity C-reactive protein and glycated hemoglobin in prediction of risk of obstructive sleep apnea. Methods We included all individuals participating in a check-up program at the Preventive Medicine Center of Hospital Israelita Albert Einstein in 2014. The Berlin questionnaire for risk of obstructive sleep apnea was used, and the high sensitivity C-reactive protein and glycated hemoglobin levels were evaluated. Results The sample included 7,115 participants (age 43.4±9.6 years, 24.4% women). The Berlin […]

Sarcopenia and chemotherapy-mediated toxicity

Maria Cecília Monteiro Dela Vega, Alessandro Laviano, Gustavo Duarte Pimentel

DOI: 10.1590/s1679-45082016md3740

ABSTRACTThis narrative review focuses on the role of sarcopenia and chemotherapy-induced toxicity in cancer patients. Consistent evidence shows that sarcopenia in cancer patients leads to decreased overall survival by influencing treatment discontinuation and dose reduction. Therefore, sarcopenia should be considered a robust prognostic factor of negative outcome as well as a determinant of increased healthcare costs.

Superoxide overproduction and kidney fibrosis: a new animal model

Nadia Karina Guimarães-Souza, Liliya Marsovna Yamaleyeva, Baisong Lu, Ana Claudia Mallet de Souza Ramos, Colin Edward Bishop, Karl Erik Andersson

DOI: 10.1590/S1679-45082015AO3179

ObjectiveTo establish whether the mutation in the Immp2L gene induces renal fibrosis and whether aging exacerbates renal morphology in mice.MethodsFemale mutant mice with mutation in the inner mitochondrial membrane peptidase 2-like protein at 3 and 18 months of age were used. Renal fibrosis was analyzed using classic fibrosis score, Masson’s trichrome staining, and analysis of profibrotic markers using real time polymerase chain reaction (superoxide dismutase 1, metalloproteinase-9, erythropoietin, transforming growth factor beta), and immunostaining (fibroblasts and Type IV collagen). Oxidative […]

Relation between leukocyte count, adiposity, and cardiorespiratory fitness in pubertal adolescents

Thiago Ricardo dos Santos Tenório, Breno Quintella Farah, Raphael Mendes Ritti-Dias, João Paulo Botero, Daniel Calado Brito, Patrícia Muniz Mendes Freire de Moura, [...]

DOI: 10.1590/S1679-45082014AO3214

ObjectiveTo compare the total and differential leukocyte count in obese and normal-weight adolescents, and to verify their possible relations with cardiorespiratory fitness and adiposity indicators.MethodsA cross-sectional study conducted with 139 adolescents (107 obese and 32 normal weight) aged between 13 and 18 years. Cardiorespiratory fitness was determined by direct gas analysis during an incremental treadmill test. Total leukocytes and subsets were estimated by flow cytometry. Body composition was assessed by dual-energy X-ray absorptiometry. Thet-test for independent samples was used for […]

Obesity versus osteoarthritis: beyond the mechanical overload

Angélica Rossi Sartori-Cintra, Priscila Aikawa, Dennys Esper Correa Cintra

DOI: 10.1590/s1679-45082014rb2912

Obesity is currently considered a major public health problem in the world, already reaching epidemic characteristics, according to the World Health Organization. Excess weight is the major risk factor associated with various diseases, such as type 2 diabetes mellitus, hypertension, dyslipidemia and osteometabolic diseases, including osteoporosis and osteoarthritis. Osteoarthritis is the most prevalent rheumatic disease and the leading cause of physical disability and reduced quality of life of the population over 65 years. It mainly involves the joints that bear […]

Short-term effects of moderate intensity physical activity in patients with metabolic syndrome

Caroline Macoris Colombo, Rafael Michel de Macedo, Miguel Morita Fernandes-Silva, Alexandra Moro Caporal, Andréa Emilia Stinghen, Costantino Roberto Costantini, [...]

DOI: 10.1590/S1679-45082013000300011

OBJECTIVES:To evaluate whether a short-term moderate intensity exercise program could change inflammatory parameters, and improve different components of metabolic syndrome in sedentary patients.METHODS:Sixteen patients completed the 12-week program of supervised exercise, which consisted of a 40 to 50 minutes of walking, 3 times a week, reaching 50 to 60% of the heart rate reserve. The parameters evaluated before and after intervention were waist circumference, systolic and diastolic blood pressure, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, C-reactive protein and interleukin […]

Relevance of prehypertension as a diagnostic category in asymptomatic adults

Fernando Costa Nary, Raul D. Santos, Antonio Gabriele Laurinavicius, Raquel Dilguerian de Oliveira Conceição, José Antonio Maluf de Carvalho

DOI: 10.1590/S1679-45082013000300008

Objective:To assess the association of prehypertension with metabolic, inflammatory and cardiovascular risk profile in asymptomatic individuals.METHODS:Between 2006 and 2009, 11,011 asymptomatic adults (mean age: 43 years; 22% females), underwent a check-up protocol. They were divided into 3 groups: normotensive group (arterial pressure=120/80mmHg), prehypertensive group (arterial pressure >120/80mmHg and 140/90mmHg or prior diagnosis of hypertension). Each group metabolic and cardiovascular group profile was assessed.RESULTS:The prevalence of normotension, prehypertension and hypertension was 27.9%, 53.9% and 18.2%, respectively. Prehypertensive individuals were older (mean […]

Role of insulin hormone in modulation of inflammatory phenomena

Antonio Di Petta

DOI: 10.1590/s1679-45082011rb1564

ABSTRACTEvidence demonstrates the involvement of hormones in the development of inflammatory response. Inflammation evokes marked structural alterations of microvasculature, besides migration of leukocytes from microcirculation to the site of lesion. These alterations are caused primarily by release or activation of endogenous mediators, in which hormones play an integral role in this regulatory system. Binding sites for many hormones may be characterized by vascular structures and hematogenous cells involved with the inflammatory response. Quantitative alterations of inflammatory events involving the decrease […]

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