ABSTRACT This review synthesizes current evidence on host immune responses to bacteria, their roles in the development and progression of periodontitis, and emerging immunomodulatory therapeutic strategies designed to restore periodontal homeostasis. Periodontitis develops through interactions between a dysbiotic bacterial community that disrupts host–microbe homeostasis and a chronic, maladaptive interaction with the host immune system. Key immune subversion microorganisms such as Porphyromonas gingivalis trigger inflammation while subverting immune surveillance by evading complement-mediated clearance and impairing neutrophil function. This dual behavior creates […]

ABSTRACT Porphyromonas gingivalis (P. gingivalis) is a Gram-negative anaerobic bacterium recognized as a keystone pathogen in periodontitis. Beyond its established role in periodontal tissue destruction, accumulating evidence links P. gingivalis to several systemic conditions, including cardiovascular disease, Alzheimer’s disease, rheumatoid arthritis, diabetes mellitus, and adverse pregnancy outcomes. This review synthesizes current evidence on how P. gingivalis may contribute to systemic disease beyond the oral cavity, with particular emphasis on its virulence factors, including gingipains and lipopolysaccharide, and the pathways linking […]

Highlights ■ Finnish Diabetes Risk Score identified high diabetes risk in most patients with periodontitis. ■ High or very high T2DM risk was observed in 71.5% of participants. ■ Finnish Diabetes Risk Score ≥12 was associated with  dysglycemia and severe periodontitis. ■ Dental clinics may help detect undiagnosed  hyperglycemia early. ABSTRACT Objective: We evaluated the potential of the Finnish Diabetes Risk Score questionnaire to screen for undiagnosed hyperglycemia in patients with periodontitis, comparing its performance with that of glycated hemoglobin […]

ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with periodontal disease and identify potential biomarkers for the disease. Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to investigate the impact of omega-3 therapy with or without acetylsalicylic acid on the immunological parameters of […]

ABSTRACT Objective To determine the association between the presence of periodontal pathogens and low birthweight. Methods This observational and case-control study consisted of mothers of infants weighing