58 results

Risk profile for antiangiogenic agent-related osteonecrosis of the jaws

Raquel D’Aquino Garcia Caminha ORCID logo , Gabriela Moura Chicrala ORCID logo , Luiz Alberto Valente Soares Júnior ORCID logo , Paulo Sérgio da Silva Santos ORCID logo

DOI: 10.31744/einstein_journal/2019RW4628

ABSTRACT To establish the profile of patients who developed antiangiogenic agent-related osteonecrosis of the jaws, and identify the treatments currently used in dental management. We searched the PubMed®/Medline® and Scopus databases using the words “osteonecrosis AND antiangiogenic therapy”, with the following inclusion criteria: articles published in English, case reports, available online, and for an unlimited period. Of the 209 articles retrieved, 18 were selected, for a total of 19 case reports, since one article included two cases that met the […]

Urinary incontinence following subtotal and total hysterectomy: a systematic review

Priscila Scalabrin Longo ORCID logo , Laura Virilo Borbily ORCID logo , Felipe Placco Araujo Glina ORCID logo

DOI: 10.31744/einstein_journal/2019RW4320

ABSTRACT Objective: To evaluate the best surgical approach for the female urinary incontinence. Methods: Systematic review conducted in MEDLINE® Cochrane, EMBASE and LILACS database up to September 1st, 2017. Articles were selected according to study type, type of intervention and outcomes. Articles were selected by more than one researcher based on title, abstract and full text. The SIGN checklist was used for bias assessment. Results: A total of 165 articles were retrieved from MEDLINE® . Twenty-five studies were elected for […]

Recent advances in layered double hydroxides applied to photoprotection

Tamires Andrade da Silva ORCID logo , Tamares Andrade da Silva ORCID logo , Ticiano Gomes do Nascimento ORCID logo , Rebeca Evahides Yatsuzuka ORCID logo , Luciano Aparecido Meireles Grillo ORCID logo , Camila Braga Dornelas ORCID logo

DOI: 10.31744/einstein_journal/2019RW4456

ABSTRACT Layered double hydroxides have received more attention from researchers due to their range of applications, ease of synthesis and low cost of production. With broader knowledge about solar radiation effects on the body, the use of sunscreens has become even more important. The ability of some nanostructures, such as layered double hydroxides, to act as matrices has made it possible to obtain improvements in photoprotective formulations, with solutions to problems caused by radiation and sunscreens. This review article brings […]

Mindfulness-Based Stress Reduction on breast cancer symptoms: systematic review and meta-analysis

Flavia Del Castanhel ORCID logo , Rafaela Liberali ORCID logo

DOI: 10.31744/einstein_journal/2018RW4383

ABSTRACT Mindfulness-Based Stress Reduction practices increase the capacity for concentration and attention, and these practices are particularly effective for people with breast cancer. To analyze the effects of the application of Mindfulness-Based Stress Reduction on breast cancer symptoms. Systematic review and meta-analysis were carried out. To find suitable studies, the PubMed/ MEDLINE database was searched using the keywords “breast cancer” and “Mindfulness-Based Stress Reduction”. Studies included were published between 2013 and 2017, written in English and showed methodological quality through […]

Partnership for productive development of biosimilar products: perspectives of access to biological products in the Brazilian market

Morton Aaron Scheinberg ORCID logo , Paulo Antonio Oldani Felix ORCID logo , Igor Age Kos ORCID logo , Maurício De Angelo Andrade ORCID logo , Valderilio Feijó Azevedo ORCID logo

DOI: 10.1590/S1679-45082018RW4175

ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products. […]

Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancers

Amanda Alves da Silva, Juliane Carlotto, Inajara Rotta

DOI: 10.1590/S1679-45082018RW4074

ABSTRACT The definition of antineoplastic administration sequences can help planning of therapeutic regimens in a more rational way, and thus optimize chemotherapy effects on patients, increasing efficacy and reducing toxic effects. In this way, this study aimed to evaluate the infusion order of antineoplastic agents of the main therapeutic protocols used in the treatment of colorectal and breast cancer which are used in a tertiary hospital, identifying possible interactions dependent on the infusion sequence. For the definition of protocols adopted […]

Chemotherapy protocols and incidence of oral mucositis. An integrative review

Marina Curra, Luiz Alberto Valente Soares Junior, Manoela Domingues Martins, Paulo Sérgio da Silva Santos

DOI: 10.1590/S1679-45082018RW4007

ABSTRACT This review aimed to analyze the scientific production on severity of oral mucositis as an adverse effect of chemotherapy. To this end, we performed a search at PubMed databases combining the keywords “oral mucositis” and “chemotherapy protocol”. To describe the investigation, the following variables were considered: journal, year/place, study design, sample, protocol used and incidence of oral mucositis. A total of 547 articles were retrieved, of which 26 were selected. Out of these 26, only 2 reported severity of […]

Diagnosis and treatment of anaphylaxis: there is an urgent needs to implement the use of guidelines

Maria Luiza Kraft Köhler Ribeiro, Herberto José Chong Neto, Nelson Augusto Rosario Filho

DOI: 10.1590/S1679-45082017RW4089

ABSTRACT Anaphylaxis is a severe, life-threatening generalized or systemic hypersensitivity reaction that requires rapid and adequate care. This study aimed to obtain an integrated view of the level of physicians’ knowledge related with treatment of anaphylaxis in studies published within the last 5 years. Sixteen studies were found and four points were identified as of the great interest to the authors: (1) emergency pharmacological treatment, (2) epinephrine auto-injectors prescription, (3) knowledge of the main signs of anaphylaxis, and (4) admission […]

Elderly with knee osteoarthritis should perform nutritional assessment: integrative literature review

Isabelle Ferreira da Silva Souza, Rosa Sá de Oliveira Neta, Juliana Maria Gazzola, Marcelo Cardoso de Souza

DOI: 10.1590/S1679-45082017RW3834

ABSTRACT To review scientific literature to assess nutritional status of elderly patients with osteoarthritis in the last 16 years. This is an integrative literature review that included articles published in national and international journals indexed in PubMed, SciELO and BIREME. We selected 14 articles, and English language was predominant. The year of publication of articles ranged from 2006 to 2016, and most of papers were cross-sectional studies. To gather papers and for posterior evaluate, we used a validated data collection […]

Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis

Noel Pabalan, Hamdi Jarjanazi, Denise Maria Christofolini, Bianca Bianco, Caio Parente Barbosa

DOI: 10.1590/S1679-45082017RW3827

ABSTRACT Objective To evaluate PTPN22 C1858T polymorphism and the risk of endometriosis. Methods A meta-analysis of 10 published case-control studies (from four articles), with a total sample of 971 cases and 1,181 controls, was performed. We estimated risk (odds ratio and 95% confidence intervals) of endometriosis associations with the C1858T polymorphism. Results A significant increased risk in all genetic models of the variant T allele with endometriosis (odds ratio: 3.14-5.55; p

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