Manuscript submission | Sections


The norms below must be followed for all types of works, and are based on the format proposed by the International Committee of Medical Journal Editors (ICMJE), published in the article Uniform requirements for manuscripts submitted to biomedical journals, available at


Technical requirements

The authors must submit the articles containing:

  • Text typed in double-spaced 12 point Arial font, 2.5cm margin on each side, highlighting each section of the article.
  • Permission for reproduction of material and transfer of copyright form (available at the electronic submission system).
  • Authors’ statement that the manuscript is not under appreciation, and will not be submitted to publication, in another journal (available at the electronic submission system).
  • Letter of approval by the Human or Animal Research Ethics Committee of the organization where the study was carried out. Studies done in Brazil must inform the number of the CAAE – Certificate of Presentation for Ethical Consideration (
  • Informed Consent Form (ICF), for articles related to research involving human participants.
  • Conflict of interest disclosure statement of each author (available at the electronic submission system).

Preparing a manuscript



Title of the article, in Portuguese and English, which should be concise but informative.



Abstract, in Portuguese and English, with a maximum of 250 words. For original articles, the abstracts should be structured (Objective, Methods, Results, Conclusion), describing the main parts of the work and highlighting the most relevant data. For articles of other sections, the abstract should not be structured.



Specify at least 5 and at most 10 keywords, in Portuguese and English, which reflect the content of the paper. The keywords must be based on the Health Sciences Descriptors (DeCS) published by Bireme, and translated from the Medical Subject Headings (MeSH) of the National Library of Medicine, and available at:


Registry in Clinical Trials Database

Indicate, for Clinical Trials, the registry number in the clinical trials database (*

* Important note: in support of the policies on registry of clinical trials of the World Health Organization (WHO) and ICMJE, the journal einstein (São Paulo) understands the relevance of these initiatives for registration and international dissemination of information on clinical studies. It only accepts for publication the clinical research articles that have received an identification number in one of the Clinical Trials Registries validated by the criteria established by the WHO and the ICMJE, available at or at the website PubMed, in the item <>. The identification number should be shown at the end of the abstract.



It must comply with the structure required for each category of article. Citations of authors in the text must be numbered sequentially, by superscript Arabic numerals in parentheses, in all article categories. The full terms for which the abbreviations and acronyms stand for should precede their first use in the text. Do not use abbreviations or acronyms in title and abstract. In table and figure legends, the abbreviations must be followed by the full term.



They describe collaboration by individuals that deserve acknowledging but do not justify authorship. Please include acknowledgements for financial and/or technical support, etc.



They must be numbered consecutively in the same order they appear in the text, and identified by Arabic numerals. References follow the “Vancouver Style”, and the titles of journals should be abbreviated according to the style presented by the List of Journals Indexed in Index Medicus, of the National Library of Medicine, available at For any references, mention up to six authors. In case of more than six authors, mention the first six, followed by et al., as shown in the following examples:


Articles from electronic journals

da Silva AA, Juliane Carlotto J, Inajara Rotta I. Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancers. einstein (São Paulo). 2018;16(1):e4074.

Lo WC, Li W, Jones EF, Newitt DC, Kornak J, Wilmes LJ, et al. Effect of imaging parameter thresholds on MRI prediction of neoadjuvant chemotherapy response in breast cancer subtypes. PLoS One. 2016;11(2):e0142047.


Tollesfsboll TO, editor. Biological aging. Methods and protocols. New Jersey: Humana Press; 2007.

Chapters of books

Lui l, Keefe DL. Nuclear transfer methods to study aging. In: Tollesfsboll TO, editor. Biological aging. Methods and protocols. New Jersey: Humana Press; 2007. p.191-207.

Works presented in conferences

Salvalaggio PR, Coelho MP, Hidalgo R, Afonso RC, Ferraz-Neto BH. Keep your eyes on the enzymes. Grading early allograft dysfunction in liver transplantation. Liver Transpl. 2011;17(6):S294-S294. [Presented at Joint International Congress of ILTS, ELITA, and LICAGE; 2011 Jun 22-25; Valencia, Spain].


Silva RP. Aspectos genético-moleculares do sono e da privação de sono em humanos e roedores [tese]. São Paulo: Universidade Federal de São Paulo; 2013.



All tables (maximum of four tables) should contain the title and heading for columns and must be mentioned in the text. They should be numbered sequentially by Arabic numerals, in the order they appear in the text. Table footnotes should have a key for abbreviations and statistical tests used.



Figures (images, graphs, photographs and illustrations) should be mentioned in the text and submitted in greater than or equal to intended display size. The journal accepts a maximum of four figures per article. They should be numbered sequentially by Arabic numerals, in the order they appear in the text. If the figures have already been published, a written permission for reproduction must be provided by the author/editor, and the legends should include the source of publication. When saved in digital files, the resolution should comply with the following instructions:


Guidelines for formatting figures

Image Type Description Example Recommended Format Color mode Resolution
Line art An image composed of lines and text, which contains no tonal or shaded areas   tif or eps Monochrome
1 bit or RGB
900 to 1,200 dpi
Halftone A continuous tone photograph containing no text   tif RGB or Grayscale 300 dpi
Combo Image contains halftone plus text or line art elements   tif or eps RGB or Grayscale 500 to 900 dpi

Example of line art extracted from: Loureiro LV, Callegaro Filho D, Rocha Ade A, Prado BL, Mutão TS, Donnarumma Cdel C, et al. Is there publication bias towards Brazilian articles on cancer. einstein (São Paulo). 2013;11(1):15-22;

Example of halftone extracted from: Pavon LF, Marti LC, Sibov TT, Miyaki LA, Malheiros SM, Mamani JB, et al. Isolation, cultivation and characterization of CD133+ stem cells from human glioblastoma. einstein (São Paulo). 2012;10(2):197-202;

Example of combo extracted from: Souza CL, Perini GF, Hamerschlak N, Silveira PA. Plasma cell leukemia. einstein (São Paulo). 2013;11(1):132.