10 results

Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

Pedro Nazareth Aguiar Jr. ORCID logo , Pui San Tan ORCID logo , Sarah Simko ORCID logo , Carmelia Maria Noia Barreto ORCID logo , Bárbara de Souza Gutierres ORCID logo , Auro del Giglio ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019GS4414

ABSTRACT Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to androgen deprivation. Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus androgen deprivation therapy alone. Direct and indirect costs were included in the model. The effects were expressed in Quality-Adjusted Life Years adjusted for side effects. Results Compared to androgen deprivation therapy alone, the addition of chemotherapy and of abiraterone generated 0.492 and 0.999, respectively, in Quality-Adjusted […]

Influence of parental smoking on the use of alcohol and illicit drugs among adolescents

Luciano Machado Ferreira Tenório de Oliveira ORCID logo , Ana Raquel Mendes dos Santos ORCID logo , Breno Quintella Farah ORCID logo , Raphael Mendes Ritti-Dias ORCID logo , Clara Maria Silvestre Monteiro de Freitas ORCID logo , Paula Rejane Beserra Diniz ORCID logo

DOI: 10.31744/einstein_journal/2019AO4377

ABSTRACT Objective: To evaluate the association between parental smoking and the use of alcohol and illicit drugs among adolescent children. Methods: A cross-sectional study with 6,264 adolescents (59.7% female) aged between 14 and 19 years. To establish the sample, we used two-stage cluster random sampling. The data on parental smoking and use of cigarettes, alcohol and illicit drugs among adolescents were collected using a questionnaire. Results: Smoking adolescents were more prone to use alcohol (odds ratio − OR: 10.35; 95%CI: […]

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Flávia Mylla de Sousa Reis, Renata Rodrigues de Oliveira Castelo Branco, Amanda Mota Conceição, Letícia Paula Benvindo Trajano, José Felipe Pinheiro do Nascimento Vieira, Pablo Ricardo Barbosa Ferreira, [...]

DOI: 10.1590/S1679-45082018AO4150

ABSTRACT Objective To evaluate the incidence of variant hemoglobins in different health regions. Methods A descriptive, observational, and cross-sectional study with a quantitative approach based on secondary data in the internal records of the neonatal screening service – Laboratório Central de Saúde Pública do Estado do Piauí (PI, Brazil). The variables related to sex, ethnicity and positive diagnosis for variant hemoglobins were analyzed, with further population distribution of hemoglobinopathies among the macroregions of the state. Results A total of 69,180 […]

Levels of knowledge about asthma of parents of asthmatic children

Cristian Roncada, Thiago de Araujo Cardoso, Bianca Martininghi Bugança, Luísa Carolina Bischoff, Karina Soldera, Paulo Márcio Pitrez

DOI: 10.1590/S1679-45082018AO4204

ABSTRACT Objective To evaluate the levels of knowledge about asthma of parents of school children. Methods A cross-sectional study was carried out with parents of children with medical diagnosis of asthma (mild, moderate and severe), followed up at an outpatient referral center for childhood asthma in the Southern region of Brazil (Asthma Group). Parents of children with asthma in remission and healthy children were also selected (Control Group). The Newcastle Asthma Knowledge Questionnaire (NAKQ) questionnaire was applied in both groups. […]

Construction and validation of content of one instrument to assess falls in the elderly

Michele Bittencourt Silveira, Ricardo Pedrozo Saldanha, José Carlos de Carvalho Leite, Thamyres Oliveira Ferreira da Silva, Thiago Silva, Lidiane Isabel Filippin

DOI: 10.1590/S1679-45082018AO4154

ABSTRACT Objective To develop and validate the content of the online Questionnaire for Fall Risk Assessment in the Elderly. Methods The instrument was developed based on the International Classification of Functioning, Disability and Health (ICF) of the World Health Organization. Initially, the set of items was submitted to evaluation of judges (healthcare professionals with experience in elderly health), who could suggest inclusion or exclusion of questions from the instrument; they were also asked to rate each question according to the […]

Association between active commuting and elevated blood pressure in adolescents

Fábio da Silva Santana, Aline Cabral Palmeira, Marcos André Moura dos Santos, Breno Quintella Farah, Bruna Cadengue Coêlho de Souza, Raphael Mendes Ritti-Dias

DOI: 10.1590/S1679-45082017AO4093

ABSTRACT Objective: To analyze the association between active commuting and blood pressure in adolescents. Methods: This is a cross-sectional study with high school students from public education network in the state of Pernambuco, Brazil. Data from 6039 students (14 to 19 years) were collected using a questionnaire. “Physically inactive” were considered those who reported not to walk or ride a bicycle to and from school on any day of the past week, and/or those who, regardless of the weekly frequency […]

Cost effectiveness of chemohormonal therapy in patients with metastatic hormone-sensitive and non-metastatic high-risk prostate cancer

Pedro Nazareth Aguiar Jr., Carmélia Maria Noia Barreto, Bárbara de Souza Gutierres, Hakaru Tadokoro, Gilberto de Lima Lopes Jr

DOI: 10.1590/S1679-45082017GS4017

ABSTRACT Objective To assess the cost-effectiveness of chemohormonal therapy in patients with metastatic hormone-sensitive and non-metastatic high-risk prostate cancer. Methods An analytical decision model was developed to determine the cost-effectiveness of chemohormonal therapy versus androgen deprivation therapy alone in patients with metastatic hormone-sensitive prostate cancer and patients with non-metastatic high-risk prostate cancer. The cost-effectiveness in metastatic patients with a high-volume disease was assessed separately. The model used data from randomized clinical trials and drug acquisition costs in Brazil. In addition, […]

Disparities in cancer epidemiology and care delivery among Brazilian indigenous populations

Pedro Nazareth Aguiar Jr., Gustavo Trautman Stock, Gilberto de Lima Lopes Jr., Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, [...]

DOI: 10.1590/S1679-45082016AO3754

ABSTRACTObjective:To assess aspects related to cancer in indigenous population.Methods:This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression.Results:Fifty patients were included. The cancer incidence was 15.73 per 100,000. The mean age at diagnosis was 54 years and most patients were female […]

Content validity of the Geriatric Health Assessment Instrument

Rhaine Borges Santos Pedreira, Saulo Vasconcelos Rocha, Clarice Alves dos Santos, Lélia Renata Carneiro Vasconcelos, Martha Cerqueira Reis

DOI: 10.1590/S1679-45082016AO3455

ABSTRACTObjectiveAssess the content validity of the Elderly Health Assessment Tool with low education.Methods The data collection instrument/questionnaire was prepared and submitted to an expert panel comprising four healthcare professionals experienced in research on epidemiology of aging. The experts were allowed to suggest item inclusion/exclusion and were asked to rate the ability of individual items in questionnaire blocks to encompass target dimensions as “not valid”, “somewhat valid” or “valid”, using an interval scale. Percent agreement and the Content Validity Index were […]

Treatment of varicose ulcer of the lower limbs by surgery and Unna boot: savings for the Brazilian healthcare system

Sergio Quilici Belczak, Vitor Cervantes Gornati, Ricardo Aun, Igor Rafael Sincos, Hélio Fragoso

DOI: 10.1590/s1679-45082011gs1984

ABSTRACTObjective:To perform an analysis of the costs of treatment of varicose ulcers by radical surgery of varices and the use of Unna boot.Methods:Fifteen outpatients were selected to receive treatment of varicose ulcers with radical surgery and Unna boot. The total cost of treatment was calculated (hospitalization, surgery, dressings, and outpatient’s follow-up visits) and compared to the cost of clinical follow-up with daily simple dressing changes.Results:The proposed treatment was on average 55.71% more economical than the management with daily dressings (approximately […]