Highlights ■ Remaining obese over time was independently associated with higher odds of depression. ABSTRACT Objective: To evaluate the association between longitudinal self-initiated changes in body mass index patterns and depression in a large sample of adults and older individuals. Methods: Participants included 1,944 adults and older individuals with depressive symptoms at baseline who underwent routine health screening examinations. Depression was defined as Beck Depression Inventory-II scores ≥14. Body mass index, blood pressure, blood samples, alcohol consumption, smoking status, physical […]

Highlights ■ Sugar-sweetened beverages are linked to a poorer inflammatory profile in adolescents. ■ Ultra-processed food intake is associated with a higher leptin/adiponectin ratio. ■ The leptin/adiponectin ratio reflects metabolic risk in adolescent obesity. ■ Dietary quality influences inflammatory hormonal markers. ABSTRACT Objective: To evaluate the relationship between dietary patterns and inflammatory markers in Brazilian adolescents with obesity. Methods: A cross-sectional analysis was conducted among 70 post-pubertal adolescents aged 15–19 years of both sexes who were classified as obese according […]

Highlights ■ The institutional nutritional program in tertiary care was effective in promoting moderate weight loss. ■ Obese patients with high cardiovascular risk undergoing multi-drug therapy showed significant improvement in anthropometric, biochemical, and heart rate variability components. ■ Heart rate variability analysis revealed enhanced autonomic balance, increased parasympathetic activity, and reduced sympathetic activity after weight loss. ■ Moderate weight loss presents a promising adjunctive  strategy for managing cardiovascular risk in obese patients undergoing multi-drug therapy. Abstract Objective: Cardiovascular diseases remain […]

Highlights Levels of lower urinary tract symptoms increased the risk of depression. Erectile dysfunction, alcohol consumption, and body mass index were associated with an increased likelihood of depression. ABSTRACT Objective: This study aimed to investigate the relationship between depression and erectile dysfunction while controlling for sociodemographic, physical health, psychological, and lifestyle factors. Additionally, it aimed to compare erectile dysfunction with other clinical, laboratory, and behavioral variables among individuals with depression in the same population. Methods: We included 21,139 men (≥40 […]

Highlights Small-litter promotes greater body weight gain, adiposity, and metabolic abnormalities in adulthood. Small-litter -adult obese rats showed augmented hypothalamic expression of GLP1-R and Lep-R. Swimming training throughout life avoids obesity and metabolic disorders in small-litter-adult rats. Regular exercise can normalize GLP1-R and Lep-R hypothalamic expressions in small-litter-adult rats. ABSTRACT Objective: Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented […]

ABSTRACT Objective: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. Methods: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data […]

ABSTRACT Objective: To evaluate the effects of combining topiramate, bupropion and naltrexone in obesity-induced rats on their weight and subcutaneous adipose tissue. Methods: A total of 40 male Wistar rats were induced to obesity for 8 weeks and the animals were divided into 8 groups: Ctr – control, G0 – Sham, G1 – oral saline solution (1.0mL/day), G2 – topiramate (20.0mg/kg) and bupropion (5.0mg/kg), G3 – naltrexone (20.0mg/kg), G4 – topiramate (20.0mg/kg), G5 – bupropion (5.0mg/kg) and G6 – topiramate […]

ABSTRACT Objective To determine the maternal and early childhood factors associated with asthma and obesity in children aged 6 to 7 years. Methods A case-control study conducted with children aged 6 to 7 years. Applications with questions about asthma symptoms in the last 12 months, maternal and childhood data in the first 2 years of life, and anthropometric data were collected. Children who presented asthma symptoms were considered as cases and those without asthma symptoms were considered as controls, later […]

ABSTRACT Objective To estimate the prevalence of clustering of behavioral risk factors for chronic non-communicable diseases, as well as the associated factors in climacteric women. Methods This is a cross-sectional, analytical study, with random selection of climacteric women, aged between 40 and 65 years, and registered in Family Health Strategy units. The dependent variable was clustering of three or more behavioral risk factors for chronic non-communicable diseases. The definition of associated variables was made after Poisson multiple regression analysis with […]

ABSTRACT Objective: To assess the quantitative serum levels of tropomyosin receptor kinase receptor B, and to estimate its association with serum concentration of brain-derived neurotrophic factor and obesity in patients with painful and painless forms of diabetic polyneuropathy. Methods: We examined 70 patients with diabetic polyneuropathy with confirming peripheral nerve dysfunction by electroneuromyography and measuring of serum levels tropomyosin receptor kinase receptor B and brain-derived neurotrophic factor by enzyme immunoassay. Diabetic polyneuropathy was diagnosed using the modified Toronto Consensus (2011) […]