Differences between medical and surgical teams on antibiotic use

Decision making in antibiotic use is conditioned by cultural and social determinants. A paper evaluated acute medical and acute surgical teams at a London teaching hospital using ethnographic techniques (i.e., a qualitative study approach). The conclusions of the study were that in surgery, the antibiotic […]

Use of Ribaxamase (SYN-004), a beta lactamase, to prevent Clostridium difficile infection in Beta lactam treated patients: a double blind phase randomized placebo controlled trial

Beta lactam antibiotics are considered risk factors for clostridioides difficile infection. These antibiotics are excreted by the bile in the gut and maintain antibiotic levels at this site. Ceftriaxone is highly excreted by the biliary tree. This excretion can continues up to 48 hours after […]

The rise of documentation and the destruction of modern Medicine

Doctor-patient relationship has been a central concept in Medicine since Hippocrates, if not before that time. Investing time into this relationship ensures trust and communication during a patient’s most vulnerable moments. The widespread use of the electronic health record has changed the doctor-patient relationship, i.e., […]

Pembrolizumab treatment for progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy is an opportunistic brain infection caused by the JC virus, a virus commonly present in kidneys. Immunosuppressed patients with low T cell counts or function are the victims of this viral infection that is usually fatal unless the immune function is restored. […]

Recent research suggests that amyloid-beta proteins associated with Alzheimer disease can be transmitted via medical and surgical procedures person-to-person

This evidence presents the initial studies on Creutzfeldt-Jakob disease as a consequence of treatment with cadaver-derived human growth factor hormone.  Post-mortem brain tissue revealed that patients had developed cerebral amyloid deposition in addition to the lesions due to mad cow disease. Clearly, those individuals will never […]

Antibiotic management of urinary tract infections in elderly patients ( 65 years and more) in primary care and its association with bloodstream infections and all cause mortaliy: population based cohort study

This is a big data study including 157,264 patients with 312,896 urinary tract infections episodes. Of these patients, 7.2 % did not have antibiotics being prescribed and 6.2 % a delay in antibiotic prescribing. 1,539 bloodstream infections deriving from UTI were registered (0.5 %) within […]

A therapeutic strategy for all pneumonia patients: a 3-year prospective multicenter cohort study using risk factors for multiresistant pathogens to select initial empiric therapy

Pneumonia empiric therapy is currently based on the site of acquisition (community or hospital), but could be chosen, based on risk factors for multiresistant (MDR) pathogens. The authors applied an algorithm to 1,089 patients using MDR risks (antibiotic use on the last 180 days before […]

Inhaled liposomal ciprofloxacin in patients with noncystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa ( orbit-3 e orbit-4): tow phase 3, randomized controlled trials

Patients with non-cystic fibrosis bronchiectasis and lung infection due to Pseudomonas aeruginosa experience frequent infection exacerbations, decreased in quality of life, and increased in mortality. Orbit-3 and ORBIT-4 were randomized double blind, placebo controlled trials that applied liposomal ciprofloxacin or placebo inhalation to their study […]

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Cytomegalovirus infection and its reactivation is frequent after solid organs and hematopoietic stem cell transplantation, and this infection can cause significant impact on transplantation outcomes. In mouse experimental models and in hematopoietic stem cells, an infusion in the presence of strain-specific anti-cytomegolovirus, was protective. There […]

We need to develop new antibiotics

Progressing of antibiotic resistance in bacteria erodes our therapeutic resources. Some infections are caused by bacteria that have only one or no therapeutic options. New antibacterial agents should be developed, but economic considerations conspire against investing in this market. Antibiotics are used, at most, two […]

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