All publications of “Luiz Vicente Rizzo”

9 results

MHC structure and function − antigen presentation. Part 2

Anna Carla Goldberg, Luiz Vicente Rizzo

DOI: 10.1590/S1679-45082015RB3123

The second part of this review deals with the molecules and processes involved in the processing and presentation of the antigenic fragments to the T-cell receptor. Though the nature of the antigens presented varies, the most significant class of antigens is proteins, processed within the cell to be then recognized in the form of peptides, a mechanism that confers an extraordinary degree of precision to this mode of immune response. The efficiency and accuracy of this system is also the […]

MHC structure and function – antigen presentation. Part 1

Anna Carla Goldberg, Luiz Vicente Rizzo

DOI: 10.1590/S1679-45082015RB3122

The setting for the occurrence of an immune response is that of the need to cope with a vast array of different antigens from both pathogenic and non-pathogenic sources. When the first barriers against infection and innate defense fail, adaptive immune response enters the stage for recognition of the antigens by means of extremely variable molecules, namely immunoglobulins and T-cell receptors. The latter recognize the antigen exposed on cell surfaces, in the form of peptides presented by the HLA molecule. […]

Association between participation and compliance with Continuing Medical Education and care production by physicians: a cross-sectional study

Renato Melli Carrera, Miguel Cendoroglo Neto, Paulo David Scatena Gonçales, Flavio Rocha Brito Marques, Camila Sardenberg, Milton Glezer, [...]

DOI: 10.1590/S1679-45082015AO3189

ObjectivePhysician participation in Continuing Medical Education programs may be influenced by a number of factors. To evaluate the factors associated with compliance with the Continuing Medical Education requirements at a private hospital, we investigated whether physicians’ activity, measured by volumes of admissions and procedures, was associated with obtaining 40 Continuing Medical Education credits (40 hours of activities) in a 12-month cycle.MethodsIn an exclusive and non-mandatory Continuing Medical Education program, we collected physicians’ numbers of hospital admissions and numbers of surgical […]

Application of the enterprise management tools Lean Six Sigma and PMBOK in developing a program of research management

Cora Hors, Anna Carla Goldberg, Ederson Haroldo Pereira de Almeida, Fernando Galan Babio Júnior, Luiz Vicente Rizzo

DOI: 10.1590/S1679-45082012000400015

Objective:Introduce a program for the management of scientific research in a General Hospital employing the business management tools Lean Six Sigma and PMBOK for project management in this area.METHODS:The Lean Six Sigma methodology was used to improve the management of the institution’s scientific research through a specific tool (DMAIC) for identification, implementation and posterior analysis based on PMBOK practices of the solutions found.RESULTS:We present our solutions for the management of institutional research projects at the Sociedade Beneficente Israelita Brasileira Albert […]

From bone marrow transplantation to complex biological therapy

Luciana Cavalheiro Marti, Luiz Vicente Rizzo

DOI: 10.1590/S1679-45082011RB2023

ABSTRACT The major complications after bone marrow transplant are related to opportunistic infections or to graft-versus-host disease. Today, there is a wealth of information associated with bone marrow transplantation and new treatment approaches have been proposed to overcome these complications. Behind these new therapies, such as adoptive transfer of T cells or mesenchymal stem cell infusions, there is significant basic research to support these clinical advances. Most of this knowledge has derived from the development of animal models and intense […]

Autoimmune uveitis: study of treatment therapies

Alessandra Gonçalves Commodaro, Luciana de Deus Vieira de Moraes, Denise Vilarinho Tambourgi, Rubens Belfort Jr., Osvaldo Augusto Sant’Anna, Luiz Vicente Rizzo

DOI: 10.1590/s1679-45082010rb1416

ABSTRACTExperimental autoimmune uveitis is an organ-specific T-cell mediated autoimmune disease characterized by inflammation and consequent destruction of the neural retina and adjacent tissues. Inflammation in experimental autoimmune uveitis may be induced in rodents by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein. We present a review of experimental studies that correlate primary immunobiological functions with this chronic disease and the possible use of molecules for the treatment of autoimmune uveitis.