All publications of “Paolo Salvalaggio”

9 results

Transection of the hepatic parenchyma associated or not with the contralateral portal vein branch ligature and its effect in liver regeneration

Henrique de Aguiar Wiederkehr, Julio Cesar Wiederkehr, Luiz Martins Collaço, Eros Luiz de Sousa, Paolo Salvalaggio, Caroline Aragão de Carvalho, [...]

DOI: 10.1590/S1679-45082017AO3831

ABSTRACT Objective To analyze the influence of portal vein ligation in hepatic regeneration by immunohistochemical criteria. Methods Ten pigs divided into two groups of five animals underwent hepatectomy in two stages, and the groups were differentiated by ligation or not of the left portal vein tributary, which is responsible for vascularization of the left lateral and medial lobes of the pig liver. Five days after the procedure, the animals underwent liver biopsies for further analysis of histological and immunohistochemical with […]

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Douglas Bastos Neves, Marcela Balbo Rusi, Luiz Gustavo Guedes Diaz, Paolo Salvalaggio

DOI: 10.1590/s1679-45082016rw3585

ABSTRACTPrimary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: “primary graft dysfunction”, “early allograft dysfunction”, “primary non-function” and “liver transplantation”. Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery- and recipient-related factors have been […]

Pancreas transplantation: review

Roberto Ferreira Meirelles Júnior, Paolo Salvalaggio, Alvaro Pacheco-Silva

DOI: 10.1590/S1679-45082015RW3163

ABSTRACTVascularized pancreas transplantation is the only treatment that establishes normal glucose levels and normalizes glycosylated hemoglobin levels in type 1 diabetic patients. The first vascularized pancreas transplant was performed by William Kelly and Richard Lillehei, to treat a type 1 diabetes patient, in December 1966. In Brazil, Edison Teixeira performed the first isolated segmental pancreas transplant in 1968. Until the 1980s, pancreas transplants were restricted to a few centers of the United States and Europe. The introduction of tacrolimus and […]

Liver transplantation: history, outcomes and perspectives

Roberto Ferreira Meirelles Júnior, Paolo Salvalaggio, Marcelo Bruno de Rezende, Andréia Silva Evangelista, Bianca Della Guardia, Celso Eduardo Lourenço Matielo, [...]

DOI: 10.1590/S1679-45082015RW3164

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two […]

Intestinal and multivisceral transplantation

Sérgio Paiva Meira Filho, Bianca Della Guardia, Andréia Silva Evangelista, Celso Eduardo Lourenço Matielo, Douglas Bastos Neves, Fernando Luis Pandullo, [...]

DOI: 10.1590/S1679-45082015RW3155

Intestinal transplantation has shown exceptional growth over the past 10 years. At the end of the 1990’s, intestinal transplantation moved out of the experimental realm to become a routine practice in treating patients with severe complications related to total parenteral nutrition and intestinal failure. In the last years, several centers reported an increasing improvement in survival outcomes (about 80%), during the first 12 months after surgery, but long-term survival is still a challenge. Several advances led to clinical application of […]

Development of laparoscopic skills in Medical students naive to surgical training

Worens Luiz Pereira Cavalini, Christiano Marlo Paggi Claus, Daniellson Dimbarre, Antonio Moris Cury Filho, Eduardo Aimoré Bonin, Marcelo de Paula Loureiro, [...]

DOI: 10.1590/S1679-45082014AO3237

ObjectiveTo assess the acquisition of basic laparoscopic skills of Medical students trained on a surgical simulator.MethodsFirst- and second-year Medical students participated on a laparoscopic training program on simulators. None of the students had previous classes of surgical technique, exposure to surgical practice nor training prior to the enrollment in to the study. Students´ time were collected before and after the 150-minute training. Skill acquisition was measured comparing time and scores of students and senior instructors of laparoscopic surgeryResults Sixty-eight students […]

High correlation between microbubble contrast-enhanced ultrasound, magnetic resonance and histopathology in the evaluation of hepatocellular carcinoma

Marcos Roberto Gomes de Queiroz, Miguel José Francisco Neto, Rodrigo Gobbo Garcia, Antonio Rahal Junior, Paolo Salvalaggio, Marcelo Buarque de Gusmão Funari

DOI: 10.1590/S1679-45082013000400017

OBJECTIVES:To evaluate the efficacy of microbubble contrast ultrasound in diagnosis of hepatocellular carcinoma and to compare its results with those of magnetic resonance and histopathology.METHODS:A total of 29 patients suffering from chronic liver diseases and awaiting liver transplants at Hospital Israelita Albert Einstein were subject to magnetic resonance, microbubble contrast ultrasound, and excision liver biopsies.RESULTS:Excellent agreement between magnetic resonance and microbubble contrast ultrasound was observed in this study. There was moderate agreement between both imaging methods and histopathology results.CONCLUSION:Microbubble contrast […]

A proposal to grade the severity of early allograft dysfunction after liver transplantation

Paolo Salvalaggio, Rogerio Carballo Afonso, Guilherme Felga, Ben-Hur Ferraz-Neto

DOI: 10.1590/S1679-45082013000100006

Objective:To propose a grading system for early hepatic graft dysfunction.METHODS:A retrospective study from a single transplant center. Recipients of liver transplants from deceased donors, transplanted under the MELD system were included. Early graft dysfunction was defined by Olthoff criteria. Multiple cut-off points of post-transplant laboratory tests were used to create a grading system for early graft dysfunction. The primary outcome was 6-months grafts survival.RESULTS:The peak of aminotransferases during the first postoperative week correlated with graft loss. The recipients were divided […]

The MELD system and liver transplant waiting-list mortality in developing countries: lessons learned from São Paulo, Brazil

Paolo Salvalaggio, Rogerio Carballo Afonso, Luiz Augusto Pereira, Ben-Hur Ferraz-Neto

DOI: 10.1590/S1679-45082012000300004

Objective:The MELD system has not yet been tested as an allocation tool for liver transplantation in the developing countries. In 2006, MELD (Model for End-stage Liver Disease) was launched as a new liver allocation system in São Paulo, Brazil. This study was designed to assess the results of the new allocation policy on waiting list mortality.METHODS:The State of São Paulo liver transplant database was retrospectively reviewed from July 2003 through July 2009. Patients were divided into those who were transplanted […]