Highlights ■ Becoming physically active was associated with low odds  of erectile dysfunction. ■ Remaining physically active was associated with low odds  of erectile dysfunction. ABSTRACT Objective: The effect of self-initiated changes in physical activity patterns over time on erectile dysfunction remains unclear. We aimed to analyze the relationship between self-initiated changes in physical activity over time and erectile dysfunction in a large sample of men. Methods: This study included 925 adults and older men with erectile dysfunction who underwent […]

Highlights ■ The SCAT-5 is a questionnaire for the follow-up of patients diagnosed with cerebral concussion. ■ The SCAT-5 was translated from English to Brazilian Portuguese, back-translated, and evaluated by an expert committee. The final version was tested twice on athletes admitted to the cerebral concussion in Sports outpatient clinic with concussion. ■ The SCAT-5 was successfully translated and culturally adapted for use in Brazilian patients. The agreement between the first and second tests was moderate for “irritability” and good […]

Highlights ■ In situ simulation prepares healthcare teams for hospital fire emergencies. ■ Simulation strengthens teamwork, communication, and  safety culture. ■ This study demonstrates that simulation enables the  identification of latent threats and gaps in institutional protocols. ■ In situ training contributes to organizational readiness and emergency planning. ABSTRACT Objective: To evaluate in situ simulations as a training strategy for the initial care of trauma victims in a hospital fire scenario. Methods: A qualitative, descriptive, and exploratory study was conducted […]

Highlights ■ This large real-world study analyzed blood cholesterol trends over a 15-year period in São Paulo, Brazil. ■ Mean total and LDL-C decreased significantly across all groups. ■ A higher proportion of patients achieved recommended  LDL-C target levels. ■ The observed trends may reflect improvements in cardiovascular prevention strategies and treatment efficacy. ABSTRACT Objective: This study aimed to evaluate monthly trends in low-density lipoprotein cholesterol (LDL-C) levels in the examined population. Methods: Monthly trends in LDL-C levels from 2009 […]

Highlights ■ Clinical simulations enhance dengue management and  clinical reasoning in undergraduate studies. ■ Mixed methods revealed gaps in physical examinations and  uncertainties in risk classification. ■ Structured debriefing promotes metacognition and critical reflection on errors. ■ Realistic scenarios strengthen empathetic communication  and enhance patient safety. ABSTRACT Objective: To analyze how clinical simulation impacts nursing students’ proficiency in clinical evaluation, decision-making, therapeutic communication, and reporting of dengue fever with warning signs within a primary health care context. Methods: Third-term nursing […]

Highlights ■ TSO500 showed 93.39% sensitivity and high concordance with FoundationOne. ■ Comprehensive Genomic Profiling of 454 tumors revealed the genomic landscape of 57 cancer types. ■ Variants of uncertain significance comprised 57.9% of all genomic events, highlighting challenges in precision oncology. ■ Gene fusions occurred in 13% of cases, with 45.5% classified as variants of uncertain significance. ABSTRACT Background: Precision medicine has transformed cancer management by tailoring treatments to the molecular characteristics of a patient’s tumor. Comprehensive Genomic Profiling […]

Highlights ■ Inflection point agreement was low to moderate amongnon-specialist raters. ■ Thoracolumbar junction showed the lowest inter-observeragreement. ■ Results support the need for protocol standardization and  structured training. ABSTRACT Objective: To assess the intra- and inter-observer reliability of spinal inflection point localization on lateral radiographs of asymptomatic adults using a standardized measurement protocol, given its important role in sagittal alignment analysis and its potential influence on biomechanical interpretation and surgical planning. Methods: This cross-sectional study included 10 adults (five […]

Highlights ■ De-escalation of axillary surgery has become a priority in  breast cancer treatment. ■ Factors associated with the decision to omit sentinel lymph node biopsy were collected via questionnaire. ■ Sentinel lymph node biopsy was omitted more often by  private doctors and those holding a doctoral degree. ■ Continuing medical education initiatives are needed to update other groups. ABSTRACT Objective: Considering the increasing number of new breast cancer cases and the morbidity associated with axillary lymph node dissection in […]

Highlights ■ Sugar-sweetened beverages are linked to a poorer inflammatory profile in adolescents. ■ Ultra-processed food intake is associated with a higher leptin/adiponectin ratio. ■ The leptin/adiponectin ratio reflects metabolic risk in adolescent obesity. ■ Dietary quality influences inflammatory hormonal markers. ABSTRACT Objective: To evaluate the relationship between dietary patterns and inflammatory markers in Brazilian adolescents with obesity. Methods: A cross-sectional analysis was conducted among 70 post-pubertal adolescents aged 15–19 years of both sexes who were classified as obese according […]

Highlights ■ Instrument developed to assess medical students’ perceptions of OSCEs. ■ Evidence of strong validity and excellent internal consistency. ■ Formative and summative OSCE modalities were also assessed. ■ Tool supports educational assessment and feedback in medical education. ABSTRACT Objective: To develop, validate, and apply an instrument aimed at assessing medical students’ perceptions of the impact of an Objective Structured Clinical Examination (OSCE), both in its peer-based formative and traditional summative modalities, on clinical learning. Methods: This study used […]