Highlights ■ Cow’s milk oral immunotherapy maintained desensitization over five years. ■ Anaphylactic reactions were more frequent during the first maintenance year. ■ The risk of eosinophilic esophagitis persisted throughout follow-up. ■ Continuous monitoring for allergic reactions and esophagitis symptoms is required. ABSTRACT Objective: To describe the long-term outcomes of patients undergoing oral immunotherapy for cow’s milk allergy in a pediatric allergy clinic, focusing on treatment efficacy and adverse reactions over 5 years of follow-up. Methods: This retrospective cohort study […]

ABSTRACT Food allergies are the leading cause of anaphylaxis in children. Cofactors, such as exercise and non-steroidal anti-inflammatory drugs, may influence the occurrence and severity of allergic reactions to food. However, despite their relevance, the underlying mechanisms of cofactor-enhanced food allergies remain poorly understood. We report the case of a 12-year-old girl with mitochondrial DNA depletion syndrome who was referred to an allergy appointment due to suspected ibuprofen hypersensitivity. Detailed anamnesis, laboratory assessment, and negative drug challenge results excluded this […]

Colite alérgica é manifestação clínica de alergia alimentar durante os primeiros meses de vida. Estima-se que fatores genéticos exerçam papel na expressão dessa doença alérgica. Neste relato de casos, foi descrita a evolução clínica de lactentes primos entre si, pertencentes a dois grupos familiares distintos com colite alérgica. Foram estudados 5 lactentes, menores de 6 meses de idade, de ambos os gêneros, com diagnóstico de colite alérgica caracterizada clínica e histologicamente por: (1) sangramento retal; (2) exclusão de causas infecciosas […]