Highlights ■ Cow’s milk oral immunotherapy maintained desensitization over five years. ■ Anaphylactic reactions were more frequent during the first maintenance year. ■ The risk of eosinophilic esophagitis persisted throughout follow-up. ■ Continuous monitoring for allergic reactions and esophagitis symptoms is required. ABSTRACT Objective: To describe the long-term outcomes of patients undergoing oral immunotherapy for cow’s milk allergy in a pediatric allergy clinic, focusing on treatment efficacy and adverse reactions over 5 years of follow-up. Methods: This retrospective cohort study […]

ABSTRACT Food allergies are the leading cause of anaphylaxis in children. Cofactors, such as exercise and non-steroidal anti-inflammatory drugs, may influence the occurrence and severity of allergic reactions to food. However, despite their relevance, the underlying mechanisms of cofactor-enhanced food allergies remain poorly understood. We report the case of a 12-year-old girl with mitochondrial DNA depletion syndrome who was referred to an allergy appointment due to suspected ibuprofen hypersensitivity. Detailed anamnesis, laboratory assessment, and negative drug challenge results excluded this […]

Allergic colitis is a clinical manifestation of food allergy during the first months of life. It is estimated that genetic factors play a role in the expression of this allergic disease. This case report described the clinical progress of infants who were cousins from two distinct family groups with allergic colitis. Five infants under six months of age and of both sexes were studied, with a diagnosis of allergic colitis characterized clinically and histologically by (1) rectal bleeding; (2) exclusion […]