Highlights ■ Cow’s milk oral immunotherapy maintained desensitization over five years. ■ Anaphylactic reactions were more frequent during the first maintenance year. ■ The risk of eosinophilic esophagitis persisted throughout follow-up. ■ Continuous monitoring for allergic reactions and esophagitis symptoms is required. ABSTRACT Objective: To describe the long-term outcomes of patients undergoing oral immunotherapy for cow’s milk allergy in a pediatric allergy clinic, focusing on treatment efficacy and adverse reactions over 5 years of follow-up. Methods: This retrospective cohort study […]

ABSTRACT The fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is administered. The usual practice is to avoid the drug involved and to use a structurally different drug. However, there are situations in which there is no safe and effective therapy. In such situations, desensitization is the only option. We describe the case of a patient […]