All publications of “Pedro Giavina-Bianchi”

2 results

Dupilumab in the treatment of severe atopic dermatitis refractory to systemic immunosuppression: case report

Mara Huffenbaecher Giavina-Bianchi ORCID logo , Pedro Giavina-Bianchi ORCID logo , Luiz Vicente Rizzo ORCID logo

DOI: 10.31744/einstein_journal/2019RC4599

ABSTRACT Case report of a patient with severe atopic dermatitis who showed a good response to dupilumab. She had already used two immunosuppressive agents, cyclosporine A and mycophenolate mofetil, for the treatment of atopic dermatitis with no proper control of the disease. She had also been taking all measures to control severe cases of the disease: bath and environmental controls, topical potent corticosteroids and emollients. She presented constant pruritus and skin lesions, frequent skin infections e poor quality of life. […]

Sensitization by subcutaneous route is superior to intraperitoneal route in induction of asthma by house dust mite in a murine mode

Marcelo Vivolo Aun, Beatriz Mangueira Saraiva-Romanholo, Francine Maria de Almeida, Thayse Regina Brüggemann, Jorge Kalil, Milton de Arruda Martins, [...]

DOI: 10.1590/S1679-45082015AO3389

ABSTRACTObjective To develop a new experimental model of chronic allergic pulmonary disease induced by house dust mite, with marked production of specific immunoglobulin E (IgE), eosinophilic inflammatory infiltrate in the airways and remodeling, comparing two different routes of sensitization.Methods The protocol lasted 30 days. BALB/c mice were divided into six groups and were sensitized subcutaneously or intraperitoneally with saline (negative control), Dermatophagoides pteronyssinus (Der p) 50 or 500mcg in three injections. Subsequently they underwent intranasal challenge with Der p or […]