Male sex is an independent risk factor for poor neurodevelopmental outcome at 20 months’ corrected age, in human milk-fed very preterm infants: a cohort study

Israel Macedo ORCID logo , Luis Pereira-da-Silva ORCID logo , Lília Brito ORCID logo , Manuela Cardoso ORCID logo

DOI: 10.31744/einstein_journal/2019AO4607

ABSTRACT Objective: To determine associations between sex and neurodevelopmental outcomes in human milk-fed very preterm infants, adjusted to early measured nutrient intakes and other neonatal cofactors. Methods: Consecutive inborn human milk-fed infants, with gestational age

Reproductive alternatives for patients with dystrophic epidermolysis bullosa

Denise Maria Christofolini ORCID logo , José Ricardo Magliocco Ceroni ORCID logo , Giovanna Guimarães Soares ORCID logo , Gustavo Bertollini Lamy ORCID logo , Ana Carolina Nemeth Calvo ORCID logo , Tamara Alba dos Santos ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019RC4577

ABSTRACT Epidermolysis bullosa describes a group of skin conditions caused by mutations in genes encoding proteins related to dermal-epidermal adhesion. In the United States, 50 cases of epidermolysis bullosa per 1 million live births are estimated, 92% of which classified as simplex, 5% dystrophic, 1% junctional and 2% non-classified. Dystrophic epidermolysis bullosa is associated with autosomal, dominant and recessive inheritance. Epidermolysis bullosa causes severe psychological, economic and social impacts, and there is currently no curative therapy, only symptom control. Embryonic […]

Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

Janyerson Dannys Pereira da Silva ORCID logo , Gustavo Ballejo ORCID logo

DOI: 10.31744/einstein_journal/2019AO4600

ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described as selective inhibitors for ORAI (BTP2/Pyr2 and Pyr6) and TRPC3 (Pyr3 and Pyr10) channels, upon endothelium- and extracellular calcium-dependent relaxations stimulated by acetylcholine and thapsigargin, in pre-constricted rat thoracic aortic rings. Results: Acetylcholine and thapsigargin responses were completely reverted by Pyr2 […]

Ultrasonography and magnetic resonance imaging of elbow ligaments: a comparative study

Aureliano Torquato Brandão ORCID logo , Edson Amaro Junior ORCID logo , Miguel José Francisco Neto ORCID logo , Rubens Mitsuo Tanaka ORCID logo , Durval do Carmo Barros Santos ORCID logo , Frederico Celestino Miranda ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4579

ABSTRACT Objective: To determine the value of ultrasonography in elbow ligament assessment compared to magnetic resonance imaging. Methods: A prospective single-center study involving 30 volunteers with no elbow joint changes. Two experienced ultrasound specialists evaluated both elbows of each volunteer, resulting in 60 evaluations per physician and totaling up 120 evaluations. Magnetic resonance images were obtained using a 3-Tesla machine and evaluated by two experienced radiologists, totaling up 120 exams. Each examiner assigned subjective, zero-to-5 scores to ligaments imaged, where […]

Laryngotracheal separation in pediatric patients: 13-year experience in a reference service

Letícia Alves Antunes ORCID logo , Carolina Talini ORCID logo , Bruna Cecília Neves de Carvalho ORCID logo , Jessica Pareja Guerra ORCID logo , Ewerton dos Santos Aristides ORCID logo , Darken Eugênio de Oliveira ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4467

ABSTRACT Objective: To evaluate clinical stability of neurologically impaired children and adolescents with recurrent pneumonia submitted to laryngotracheal separation. Methods: Between October 2002 and June 2015, 92 neurologically impaired children from a reference service, with median age of 68.5 months were submitted to laryngotracheal separation. Data were evaluated and statistical analysis was made by Student’s t test and Pearson’s χ2 test (significance level adopted of 95%). Results: Fifty-three children were male (57.6%). Forty-six children required admission to intensive care, and […]

Is virtual reality useful for pain management in patients who undergo medical procedures?

Daniel Melecchi de Oliveira Freitas ORCID logo , Viviane Souto Spadoni ORCID logo

DOI: 10.31744/einstein_journal/2019MD4837

ABSTRACT Pain management is a complex medical issue, and many efforts have been done to develop new non-pharmacological therapies. Virtual reality is a technology apparatus that make an interaction between human and virtual environment through an hardware (usually a headset) linked to a computer or a mobile, by using a software. Additionally, this virtual setting can be adapted to any type of scenario. Thus, it is plausible that the software used should be personalized depending on patient’s experiences and expectations. […]

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly

Sandra Elisa Adami Batista Gonçalves ORCID logo , Andreza Alice Feitosa Ribeiro ORCID logo , Erika Yuri Hirose ORCID logo , Fabio Pires de Souza Santos ORCID logo , Flávia Munhoz Ferreira ORCID logo , Ludmila de Oliveira Muniz Koch ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AE4340

ABSTRACT The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly was elaborated by nutritionists, nutrologists and hematologists physicians from 15 Brazilians reference centers in hematopoietic stem cell transplantation, in order to emphasize the importancy of nutritional status and the body composition during the treatment, as well as the main characteristics related to patient’s nutritional assessment. Establishing the consensus, we intended to improve and standardize the nutritional therapy during the hematopoietic stem cell transplantation. The Consensus was approved by the […]

Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications

Thiago de Lima Pessoa ORCID logo , Washington Sales Clemente Junior ORCID logo , Tatiana Xavier da Costa ORCID logo , Priscilla Karilline do Vale Bezerra ORCID logo , Rand Randall Martins ORCID logo

DOI: 10.31744/einstein_journal/2019AO4521

ABSTRACT Objective: To characterize severe potential drug interactions in maternal intensive care, and to determine their frequency, risk factors and potential risk medications. Methods: An observational and longitudinal study conducted between December 2014 and December 2015 in a maternal intensive care unit. Clinical data were collected and severe potential drug interactions were identified on pregnant inpatients. The drug interactions were classified by type, prevalence and exposure rate. A multivariate logistic regression model was used to identify the severe potential drug […]

Body composition, strength static and isokinetic, and bone health: comparative study between active adults and amateur soccer players

Óscar M. Tavares ORCID logo , João P. Duarte ORCID logo , André O. Werneck ORCID logo , Daniela C. Costa ORCID logo , Paulo Sousa-e-Silva ORCID logo , Diogo Martinho ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4419

ABSTRACT Objective: To compare tissue composition, total and regional bone mineral content and bone mineral density, static hand grip and knee joint isokinetic strength between amateur soccer players and Control Group. Methods: Cross-sectional study. Air displacement plethysmography was used to estimate body volume and, in turn, density. Body composition, bone mineral content and bone mineral density were assessed for the whole body and at standardized regions using dual energy X-ray absorptiometry. Static grip strength was assessed with an adjustable dynamometer, […]

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