5 results

Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancers

Amanda Alves da Silva, Juliane Carlotto, Inajara Rotta

DOI: 10.1590/S1679-45082018RW4074

ABSTRACT The definition of antineoplastic administration sequences can help planning of therapeutic regimens in a more rational way, and thus optimize chemotherapy effects on patients, increasing efficacy and reducing toxic effects. In this way, this study aimed to evaluate the infusion order of antineoplastic agents of the main therapeutic protocols used in the treatment of colorectal and breast cancer which are used in a tertiary hospital, identifying possible interactions dependent on the infusion sequence. For the definition of protocols adopted […]

The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma

Guilherme Muniz Bourroul, Hélio José Fragoso, José Walter Feitosa Gomes, Vivian Sati Oba Bourroul, Celina Tizuko Fujiyama Oshima, Thiago Simão Gomes, [...]

DOI: 10.1590/S1679-45082016AO3678

ABSTRACTObjectiveTo evaluate the destruction complex of beta-catenin by the expression of the proteins beta-catetenin, adenomatous polyposis coli, GSK3β, axin and ubiquitin in colorectal carcinoma and colonic adenoma.Methods Tissue samples from 64 patients with colorectal carcinoma and 53 patients with colonic adenoma were analyzed. Tissue microarray blocks and slides were prepared and subjected to immunohistochemistry with polyclonal antibodies in carcinoma, adjacent non-neoplastic mucosa, and adenoma tissues. The immunoreactivity was evaluated by the percentage of positive stained cells and by the intensity […]

Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by electrospray ionization mass spectrometry

Ana Paula Cleto Marolla, Jaques Waisberg, Gabriela Tognini Saba, Daniel Reis Waisberg, Fernando Beani Margeotto, Maria Aparecida da Silva Pinhal

DOI: 10.1590/S1679-45082015AO3477

ABSTRACTObjective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression.Methods Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metastases. Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by electrospray ionization mass spectrometry, with the technique for extraction and quantification of glycosaminoglycans […]

Left colectomy with intracoporeal anastomosis: technical aspects

Sérgio Eduardo Alonso Araujo, Victor Edmond Seid, Sidney Klajner, Alexandre Bruno Bertoncini

DOI: 10.1590/s1679-45082014md3030

Oncologic laparoscopic colectomy represents a fully validated surgical approach to the management of colorectal cancer. However, laparoscopic surgery for distal transverse and descending colon lesions remains a challenging procedure. A total laparoscopic approach to the left colectomy is an interesting option for critically ill patients although reports in the literature on this subject are scarce and its approach still not standardized because of its selective nature for indication. There are several advantages associated with conduction of totally laparoscopic approach to […]

En bloc pancreaticoduodenectomy and right hemicolectomy to treat locally advanced right colon cancer: report of three cases

Sergio Renato Pais Costa, Sergio Henrique Couto Horta, Alexandre Cruz Henriques, Jaques Waisberg, Manlio Basílio Speranzini

DOI: 10.1590/s1679-45082010rc786

ABSTRACTAlthough colorectal tumors are fairly common surgical conditions, 5 to 12% of these tumors are locally advanced (T4 tumors) upon diagnosis. In this particular situation, the efficacy of en bloc multivisceral resection has been proven. When right-colon cancer invades the proximal duodenum or even the pancreatic head, a challenging dilemma arises due to complexity of the curative surgical procedure. Therefore, en bloc pancreaticoduodenectomy with right hemicolectomy should be performed to obtain free margins. The present study reports three cases of […]