ABSTRACT This report presents a case of a 59-year-old male diagnosed with metastatic esophagogastric junction adenocarcinoma, who presented with mild dysphagia and vertigo. Brain magnetic resonance imaging initially showed no abnormalities. Upper gastrointestinal endoscopy revealed a vegetative lesion in the distal esophagus, and concurrent colonoscopy identified a laterally-spreading tumor in the transverse colon. Immunohistochemistry confirmed a poorly differentiated adenocarcinoma, suggesting an upper gastrointestinal origin. Further investigation of the worsening neurological symptoms led to the identification of leptomeningeal carcinomatosis via cerebrospinal […]

ABSTRACT In Brief Queiroz et al. showed that the application of cluster methodology for classifying gastric cancer is suitable and efficient within a Brazilian cohort, which is known for its population heterogeneity. The study highlighted the potential utilization of this method within public health services due to its low-cost, presenting a viable means to improve the diagnosis and prognosis of gastric cancer. Highlights Our Brazilian cohort with gastric cancer has a distinct distribution between mutated and normal p53. New genetic […]

Category: Respiratory Endoscopy Introduction: Histopathological analyses and classification by the Tumor, Node, Metastasis System (TNM) are key-elements in therapeutic decision-making for non-small cell lung cancer (NSCLC).() Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is effective in obtaining biopsies of hilar and mediastinal lymph nodes (MLN), for tissue collection to mediastinal staging in NSCLC.(,) The assessment of clinically significant genomic alterations in surgically resected primary tumors (PT) and MLN aspirates obtained by EBUS-TBNA can provide valuable insights into the risk of recurrence, […]

Highlights PD-L1 expression by immunohistochemistry is positive in more than half on stage III non-small lung cancer. PD-L1 expression by immunohistochemistry had no relationship with clinical characteristics. PD-L1 expression by immunohistochemistry is not related to progression-free or overall survival in patients treated with chemoradiotherapy with or without surgery. ABSTRACT Objective: Currently programmed cell death protein 1 (PD-1) inhibitors in combination with other therapies are being evaluated to determine their efficacy in cancer treatment. However, the effect of PD-ligand (L) 1 […]

ABSTRACT Although colorectal tumors are fairly common surgical conditions, 5 to 12% of these tumors are locally advanced (T4 tumors) upon diagnosis. In this particular situation, the efficacy of en bloc multivisceral resection has been proven. When right-colon cancer invades the proximal duodenum or even the pancreatic head, a challenging dilemma arises due to complexity of the curative surgical procedure. Therefore, en bloc pancreaticoduodenectomy with right hemicolectomy should be performed to obtain free margins. The present study reports three cases […]