Highlights ■ The 35 navigation metrics by AONN+ were cross-culturally  adapted. ■ Navigation metrics support the standardization of evaluating navigation results for programs in Brazil. ABSTRACT Objective: To perform the translation and cross-cultural adaptation into Brazilian Portuguese of the 35 navigation metrics developed by the Academy of Oncology Nurse & Patient Navigators (AONN+). Methods: This study employed a methodological approach for cross-cultural adaptation. Following authorization from the authors of the original version of the 35 metrics for evaluating navigation programs, […]

ABSTRACT Objective: The aim of this meta-analysis was to determine the efficacy and safety of percutaneous irreversible electroporation combined with immunotherapy compared with irreversible electroporation alone in patients with locally advanced pancreatic cancer. Methods: We systematically searched Embase, Cochrane Central Register of Controlled Trials, and PubMed/Medline for relevant studies. The outcomes of interest were progression-free survival, overall survival, carbohydrate antigen 19-9 (CA 19-9) levels, and adverse events. Progression-free survival and overall survival were assessed using pooled hazard ratios (HR), odds […]

Highlights ■ EDAcw objectively quantifies sweating in patients with hyperhidrosis. ■ Sympathectomy significantly reduced EDAcw and  improved the quality of life. ■ The hands showed a 97% reduction in electrodermal activity postoperatively. ■ EDAcw is a reliable non-invasive tool for clinical evaluation and follow-up. ABSTRACT Objective: To analyze continuous exosomatic electrodermal activity (EDA) without external stimuli (EDAcw) in patients with primary hyperhidrosis before and after sympathectomy. Methods: This prospective study included 28 participants, categorized into two groups. The first group […]

Highlights ■ Immunohistochemistry distinguishes Warthin-like mucoepidermoid carcinoma from metaplastic Warthin tumor. ■ CK7, mitochondrial patterns, and double-layer epithelium suggest metaplastic Warthin tumor. ■ Basal CK14, CK5/6, and p63 distinguish metaplastic Warthin tumor from Warthin-like mucoepidermoid carcinoma. ABSTRACT Objective: This study aimed to analyze the clinicopathological and immunohistochemical profiles of unconventional Warthin tumors and mucoepidermoid carcinomas. Methods: Eleven low-grade salivary gland tumors with Warthin-like features were analyzed. Group A (n=6) showed a double-layered oncocytic epithelium in less than 50% of the […]

Highlights ■ Oxidative stress markers are associated with the intensity and consequences of ischemia-reperfusion injury during deceased-donor kidney transplantation. ■ The donor’s serum hydrogen peroxide level achieved 85.7% sensitivity and a 91.7% negative predictive value for  detecting delayed graft function lasting more than one week. ■ Donor H2O2 ≤14μM is suggested to dichotomize risk for delayed graft function lasting longer than a week. ■ This study provides pivotal information on the use of oxidative stress markers to identify patients at […]

Highlights ■ Forty-four percent of mothers of children with autism spectrum disorder have poor sleep quality. ■ Seventy percent did not meet the recommended 7-9 hours of sleep. ■ Demographic, child-related, and clinical data were associated with sleep problems. ABSTRACT Objective: To analyze the factors associated with sleep quality and duration in mothers of children with autism spectrum disorder. Methods: A cross-sectional study was conducted with 595 mothers (37±7yrs) of children and adolescents with autism spectrum disorder (8.1±3.1yrs). The assessed […]

Highlights ■ Mammary hypertrophy was not associated with postoperative totally implantable venous access device catheter tip displacement. ■ Upright and supine chest radiography with a radiopaque ruler allowed precise quantification of catheter tip displacement. ■ Non-deforming chest wall surgery and a history of peripherally inserted central catheters history were significantly associated with catheter tip migration. ABSTRACT Objective: This study aimed to evaluate the change in the position of totally implantable venous access devices in patients with mammary hypertrophy compared to […]

Highlights ■ High vaccine coverage correlated with sharp declines in the incidence of pediatric meningitis C. ■ The incidence fell by 98% by 2021 following national introduction of the MenC vaccine. ■ Vaccine coverage dropped after 2015, aligned with the rising cases observed in 2022. ■ MenC vaccination significantly reduced morbidity and mortality nationwide. ABSTRACT Objective: To analyze the correlation between vaccination coverage against meningitis C and epidemiological indicators of morbidity and mortality associated with the disease in Brazilian pediatric […]

Dear Editor, Following the publication of our editorial on evidence-based approaches to simulation-based education (SBE),() we received multiple requests from educators and the simulation community for a concise resource to support implementation at the point of curriculum design and faculty training. To address this gap, we created a one-page infographic that translates the editorial’s arguments into a practical visual aid (). […]

Highlights ■ Transoral robotic surgery applied in patients with T1–T2 oropharyngeal and laryngeal tumors. ■ Mean hospital stay: 2.1 days. ■ Minimal postoperative complications. ■ 5-year survival: 77%, with comparable cost-effectiveness. ABSTRACT Objective: To assess the feasibility and benefits of transoral robotic surgery in the public healthcare system and to conduct a cost analysis of its implementation. Methods: This prospective, nonrandomized, observational cohort study was conducted over 24 months and included patients with T1-T2 oropharyngeal and supraglottic laryngeal tumors. Results: […]