561 results

Therapeutic evaluation of magnetic hyperthermia using Fe3O4-aminosilane-coated iron oxide nanoparticles in glioblastoma animal model

Gabriel Nery de Albuquerque Rego ORCID logo , Javier Bustamante Mamani ORCID logo , Taylla Klei Felix Souza ORCID logo , Mariana Penteado Nucci ORCID logo , Helio Rodrigues da Silva ORCID logo , Lionel Fernel Gamarra ORCID logo

DOI: 10.31744/einstein_journal/2019AO4786

ABSTRACT Objective: To evaluate the potential of magnetic hyperthermia using aminosilane-coated superparamagnetic iron oxide nanoparticles in glioblastoma tumor model. Methods: The aminosilane-coated superparamagnetic iron oxide nanoparticles were analyzed as to their stability in aqueous medium and their heating potential through specific absorption rate, when submitted to magnetic hyperthermia with different frequencies and intensities of alternating magnetic field. In magnetic hyperthermia in vitro assays, the C6 cells cultured and transduced with luciferase were analyzed by bioluminescence in the absence/presence of alternating […]

Evaluation and reconditioning of donor organs for transplantation through ex vivo lung perfusion

Luis Gustavo Abdalla ORCID logo , Karina Andrighetti de Oliveira-Braga ORCID logo , Lucas Matos Fernandes ORCID logo , Marcos Naoyuki Samano ORCID logo , Paula Refinetti Camerini ORCID logo , Paulo Manuel Pêgo-Fernandes ORCID logo

DOI: 10.31744/einstein_journal/2019AO4288

ABSTRACT Objective: To assess the feasibility and impact of ex vivo lung perfusion with hyperoncotic solution (Steen Solution™) in the utilization of these organs in Brazil. Methods: In this prospective study, we subjected five lungs considered to be high risk for transplantation to 4 hours of ex vivo lung perfusion, with evaluation of oxygenation capacity. High-risk donor lungs were defined by specific criteria, including inflammatory infiltrates, pulmonary edema and partial pressure of arterial oxygen less than 300mmHg (inspired oxygen fraction […]

Comparative study between monoexponential and biexponential diffusion weighted imaging sequences in multiparametric prostate magnetic resonance imaging

Victor Martins Tonso ORCID logo , Fernando Ide Yamauchi ORCID logo , Thais Caldara Mussi ORCID logo , Eduardo Figueiredo ORCID logo , Ronaldo Hueb Baroni ORCID logo

DOI: 10.31744/einstein_journal/2019AO4615

ABSTRACT Objective: To compare qualitatively and quantitatively, in terms of image quality, a new biexponential diffusion sequence protocol with the standard monoexponential diffusion protocol on multiparametric prostate magnetic resonance imaging. Methods: This study had a prospective data collection and cross-sectional analysis. Between August and November 2017, a total of 70 patients who underwent multiparametric prostate magnetic resonance imaging due to clinical suspicion of prostatic neoplasia were recruited. The images obtained were evaluated by two independent readers regarding subjective/qualitative criteria (six […]

Chronic treatment with hydroalcoholic extract of Plathymenia reticulata promotes islet hyperplasia and improves glycemic control in diabetic rats

Fernanda Oliveira Magalhães ORCID logo , Elizabeth Uber-Bucek ORCID logo , Patricia Ibler Bernardo Ceron ORCID logo , Thiago Fellipe Name ORCID logo , Humberto Eustáquio Coelho ORCID logo , Claudio Henrique Gonçalves Barbosa ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4635

ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were allocated to one of 8 groups, as follows: diabetic and control rats treated with water, diabetic and control rats treated with 100mg/kg or 200mg/kg of plant extract, and diabetic and control rats treated with glyburide. Treatment consisted of […]

Anatomical study of the transfer of flexor digitorum superficialis nerve branch of median nerve to restore wrist extension and forearm pronation

Edie Benedito Caetano ORCID logo , Luiz Angelo Vieira ORCID logo , Cristina Schmitt Cavalheiro ORCID logo , Marcel Henrique Arcuri ORCID logo , Rodrigo Guerra Sabongi ORCID logo

DOI: 10.31744/einstein_journal/2019AO4489

Abstract Objective To analyze the anatomical variations of the innervation of the flexor digitorum superficialis muscle and to determine if the branch of the median nerve that supply this muscle is connected to the branches to the extensor carpi radialis brevis and the pronator teres muscles, without tension, and how close to the target-muscles the transfer can be performed. Methods Fifty limbs of 25 cadavers were dissected to collect data on the anatomical variations of the branches to the flexor […]

Pelvic floor muscle training alone or in combination with oxybutynin in treatment of nonmonosymptomatic enuresis. A randomized controlled trial with 2-year follow up

Renata Martins Campos ORCID logo , Adélia Correia Lúcio ORCID logo , Maria Helena Baena de Moraes Lopes ORCID logo , Claudia Rosenblatt Hacad ORCID logo , Maria Carolina Ramos Perissinotto ORCID logo , Howard I. Glazer, [...]

DOI: 10.31744/einstein_journal/2019AO4602

Abstract Objective To compare the results of the standard urotherapy alone and associated with pelvic floor muscle training alone, and in combination with oxybutynin in treatment of nonmonosymptomatic nocturnal enuresis. Methods A total of 38 children aged 5 to 10 years were randomized into three groups: Group I (n=12) that was submitted to standard urotherapy; Group II (n=15), standard urotherapy associated with pelvic floor muscle training; and Group III (n=11), standard urotherapy associated with pelvic floor muscle training and oxybutynin; […]

Physical activity level and lifestyle perception in prebariatric surgery patients

Eduardo Gauze Alexandrino ORCID logo , Danilo Francisco da Silva Marçal ORCID logo , Mateus Dias Antunes ORCID logo , Leonardo Pestillo de Oliveira ORCID logo , Ely Mitie Massuda ORCID logo , Sonia Maria Marques Gomes Bertolini ORCID logo

DOI: 10.31744/einstein_journal/2019AO4619

Abstract Objective To determine sociodemographic characteristics, lifestyle perception and physical activity levels in obese prebariatric surgery patients. Methods A quantitative, cross-sectional study. The sample comprised 96 male and female morbidly obese prebariatric surgery patients. Questionnaires addressing sociodemographic profile, lifestyle perception and physical activity levels were applied. Results Patients were aged 40.3±11.45 years. Inadequate levels of physical activity were reported by 47.8% of patients; most respondents (79.2%) attributed scores defined as inadequate to the physical activity domain of the lifestyle questionnaire. […]

Risky sexual behaviors and their association with overweight and obesity among adolescent students: a cross-sectional study

Alaine Souza Lima ORCID logo , Ana Carolina Rodarti Pitangui ORCID logo , Mayra Ruana de Alencar Gomes ORCID logo , Rachel Mola ORCID logo , Rodrigo Cappato de Araújo ORCID logo

DOI: 10.31744/einstein_journal/2019AO4782

Abstract Objective To determine the prevalence of risky sexual behavior and its association with overweight and obesity among adolescent students. Methods This is a cross-sectional study, conducted in public schools with adolescents aged 12 to 17 years. We used the questionnaire Youth Risk Behavior Survey. The body mass index percentiles were calculated by means of table from the Center for Control and Prevention of Diseases. Possible associations were assessed using the χ2 test and binary logistic regression model. The odds […]

Male sex is an independent risk factor for poor neurodevelopmental outcome at 20 months’ corrected age, in human milk-fed very preterm infants: a cohort study

Israel Macedo ORCID logo , Luis Pereira-da-Silva ORCID logo , Lília Brito ORCID logo , Manuela Cardoso ORCID logo

DOI: 10.31744/einstein_journal/2019AO4607

ABSTRACT Objective: To determine associations between sex and neurodevelopmental outcomes in human milk-fed very preterm infants, adjusted to early measured nutrient intakes and other neonatal cofactors. Methods: Consecutive inborn human milk-fed infants, with gestational age

Laryngotracheal separation in pediatric patients: 13-year experience in a reference service

Letícia Alves Antunes ORCID logo , Carolina Talini ORCID logo , Bruna Cecília Neves de Carvalho ORCID logo , Jessica Pareja Guerra ORCID logo , Ewerton dos Santos Aristides ORCID logo , Darken Eugênio de Oliveira ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4467

ABSTRACT Objective: To evaluate clinical stability of neurologically impaired children and adolescents with recurrent pneumonia submitted to laryngotracheal separation. Methods: Between October 2002 and June 2015, 92 neurologically impaired children from a reference service, with median age of 68.5 months were submitted to laryngotracheal separation. Data were evaluated and statistical analysis was made by Student’s t test and Pearson’s χ2 test (significance level adopted of 95%). Results: Fifty-three children were male (57.6%). Forty-six children required admission to intensive care, and […]

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