550 results

Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

Janyerson Dannys Pereira da Silva ORCID logo , Gustavo Ballejo ORCID logo

DOI: 10.31744/einstein_journal/2019AO4600

ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described as selective inhibitors for ORAI (BTP2/Pyr2 and Pyr6) and TRPC3 (Pyr3 and Pyr10) channels, upon endothelium- and extracellular calcium-dependent relaxations stimulated by acetylcholine and thapsigargin, in pre-constricted rat thoracic aortic rings. Results: Acetylcholine and thapsigargin responses were completely reverted by Pyr2 […]

Lipid profile and statin use in critical care setting: implications for kidney outcome

Isabelle Malbouisson ORCID logo , Beata Marie Quinto ORCID logo , Marcelino de Souza Durão Junior ORCID logo , Júlio Cesar Martins Monte ORCID logo , Oscar Fernando Pavão dos Santos ORCID logo , Roberto Camargo Narciso ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4399

ABSTRACT Objective: To determine whether pre-hospital statin use is associated with lower renal replacement therapy requirement and/or death during intensive care unit stay. Methods: Prospective cohort analysis. We analyzed 670 patients consecutively admitted to the intensive care unit of an academic tertiary-care hospital. Patients with ages ranging from 18 to 80 years admitted to the intensive care unit within the last 48 hours were included in the study. Results: Mean age was 66±16.1 years old, mean body mass index 26.6±4/9kg/m2 […]

Body composition, strength static and isokinetic, and bone health: comparative study between active adults and amateur soccer players

Óscar M. Tavares ORCID logo , João P. Duarte ORCID logo , André O. Werneck ORCID logo , Daniela C. Costa ORCID logo , Paulo Sousa-e-Silva ORCID logo , Diogo Martinho ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4419

ABSTRACT Objective: To compare tissue composition, total and regional bone mineral content and bone mineral density, static hand grip and knee joint isokinetic strength between amateur soccer players and Control Group. Methods: Cross-sectional study. Air displacement plethysmography was used to estimate body volume and, in turn, density. Body composition, bone mineral content and bone mineral density were assessed for the whole body and at standardized regions using dual energy X-ray absorptiometry. Static grip strength was assessed with an adjustable dynamometer, […]

Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications

Thiago de Lima Pessoa ORCID logo , Washington Sales Clemente Junior ORCID logo , Tatiana Xavier da Costa ORCID logo , Priscilla Karilline do Vale Bezerra ORCID logo , Rand Randall Martins ORCID logo

DOI: 10.31744/einstein_journal/2019AO4521

ABSTRACT Objective: To characterize severe potential drug interactions in maternal intensive care, and to determine their frequency, risk factors and potential risk medications. Methods: An observational and longitudinal study conducted between December 2014 and December 2015 in a maternal intensive care unit. Clinical data were collected and severe potential drug interactions were identified on pregnant inpatients. The drug interactions were classified by type, prevalence and exposure rate. A multivariate logistic regression model was used to identify the severe potential drug […]

Introduction of complementary foods in infants

Lilian Cordeiro de Queirós Moreira ORCID logo , Elizabeth Brauninger e Oliveira ORCID logo , Lucia Hitomi Kamata Lopes ORCID logo , Mariana Ercole Bauleo ORCID logo , Flavio Sarno ORCID logo

DOI: 10.31744/einstein_journal/2019AO4412

ABSTRACT Objective: To analyze frequency, age and time trend of complementary feeding introduction in infants. Methods: Retrospective study of infants’ data evaluated at nutrition sector of Programa de Atenção aos Bebês of Programa Einstein na Comunidade de Paraisópolis from 2012 to 2015. Survival analyzes were performed, and the outcome considered was the time until the introduction of each specific food. Results: Participants were 700 infants, with 5.5 months of median age. Water was the most consumed supplement (80.0%), followed by […]

Attitudes Toward Lesbians and Gay Men Scale: validation in Brazilian physicians

Renata Corrêa-Ribeiro ORCID logo , Fabio Iglesias ORCID logo , Einstein Francisco Camargos ORCID logo

DOI: 10.31744/einstein_journal/2019AO4527

ABSTRACT Objective: To perform the cross-cultural adaptation of the original North American version of the Attitudes Toward Lesbians and Gay Men Scale (ATLG) for use in Brazil, and to evaluate the psychometric properties of the adapted instrument in a sample of Brazilian heterosexual physicians. Methods: Stages of cross-cultural adaptation were as follows: translation by two independent evaluators, translation synthesis, evaluation by the target population for semantic equivalence, pilot study with 42 physicians, and final instrument preparation involving 224 heterosexual physicians […]

Hormone treatment as first line therapy is safe and relieves pelvic pain in women with bowel endometriosis

Marina Paula Andres ORCID logo , Renata Franco Pimentel Mendes ORCID logo , Camila Hernandes ORCID logo , Sérgio Eduardo Alonso Araújo ORCID logo , Sérgio Podgaec ORCID logo

DOI: 10.31744/einstein_journal/2019AO4583

ABSTRACT Objective: To evaluate clinical features and complications in patients with bowel endometriosis submitted to hormonal therapy. Methods: Retrospective study based on data extracted from medical records of 238 women with recto-sigmoid endometriosis treated between May 2010 and May 2016. Results: Over the course of follow-up, 143 (60.1%) women remained in medical treatment while 95 (39.9%) presented with worsening of pain symptoms or intestinal lesion growth (failure of medical treatment group), with surgical resection performed in 54 cases. Women in […]

Applicability of papain solutions in immunohematology

Laís Priscila De Santis ORCID logo , Patrícia Carvalho Garcia ORCID logo , Valéria Nogueira Dias Paes Secco ORCID logo , Rosana Rossi Ferreira ORCID logo , Elenice Deffune ORCID logo

DOI: 10.31744/einstein_journal/2019AO4328

ABSTRACT Objective: To compare the enzyme activity of different presentations of papain solution to validate in-house preparations. Methods: Two papain solutions were prepared, and the third presentation was a commercial solution. Tests were carried out with samples of red cells typed as weak RhD. Results: In-house prepared papain solutions showed similar enzyme reactivity, and statistically no differences compared to the enzyme activity of the commercial solution. Conclusion: Evaluating the cost-benefit ratio, the in-house prepared papain solutions present more economic advantages, […]

Most frequent errors in inhalation technique of patients with asthma treated at a tertiary care hospital

Carlos Leonardo Carvalho Pessôa ORCID logo , Maria Julia da Silva Mattos ORCID logo , Artur Renato Moura Alho ORCID logo , Marianna Martini Fischmann ORCID logo , Bruno Mendes Haerdy ORCID logo , Ana Carolina Castro Côrtes ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4397

ABSTRACT Objective: To demonstrate the most frequent errors in inhalation technique in patients with asthma undergoing treatment at a tertiary care hospital. Methods: A cross-sectional study with a convenience sample of asthma patients aged 18 years or over, treated at a pulmonology outpatient clinic of a tertiary care hospital. The assessment of inhalation technique of users of the dry powder inhalers Aerolizer®, Aerocaps and Diskus®, or metered-dose inhalers was based on the manufacturer’s instructions for use of each inhaler device. […]

Prospective randomized trial comparing radiofrequency ablation and complete saphenous vein stripping in patients with mild to moderate chronic venous disease with a 3-year follow-up

Igor Rafael Sincos ORCID logo , Anna Paula Weinhardt Baptista ORCID logo , Felipe Coelho Neto ORCID logo , Nicos Labropoulos ORCID logo , Luciane Basílio Alledi ORCID logo , Emmanuel Machado de Marins ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4526

ABSTRACT Objective: To compare the use of the radiofrequency thermoablation of the saphenous vein with the ligation technique, and complete removal of the saphenous vein, from the saphenofemoral junction to the ankle. Methods: A total of 49 patients with chronic venous disease in the Comprehensive Classification System for Chronic Venous Disorders (CEAP) classes 2 to 4 for clinical signs, etiology, anatomic distribution and pathophysiology, were assessed at baseline, after 4 weeks, and after 1 year. The parameters assessed were complications, […]

1 2 3 4 55