Highlights ■ Minimally invasive neoadjuvants are usually recommended for patients on the transplant waiting list. ■ Radiofrequency ablation showed a higher necrosis rate and superior radiological response than did percutaneous ethanol injection and transarterial chemoembolization in this study cohort. ABSTRACT Objective: We aimed to compare the radiological response in small hepatocellular carcinomas treated with radiofrequency ablation, percutaneous ethanol injection, and transarterial chemoembolization using the modified Response Evaluation Criteria in Solid Tumor radiological evaluation in patients on the waiting list for […]

Highlights ■ Patients who received early palliative care were younger with more immunosuppression. ■ Intensive care unit and hospital mortality were higher with late palliative care. ■ Early palliative care reduced the use of advanced life support resources. ABSTRACT Objectives: To describe the use of advanced life support, resource utilization, and clinical outcomes and to identify the risk factors for late initiation of palliative care support in patients at the intensive care unit. Methods: A retrospective, single-center cohort study conducted […]

Highlights ■ We developed ONCO-1, a simple tool based on tumor volume. ■ Cutoff points were defined by a CART model. ■ Tumor volume was a prognostic factor for 1-year mortality. ■ Tumor volume can to support clinical decision-making. ABSTRACT Objective: To develop a simple and accessible univariate tool based on tumor volume to predict 1-year mortality in patients with oral cavity squamous cell carcinoma. Methods: A retrospective analysis was conducted on patients with oral cavity squamous cell carcinoma included […]

Highlights ■ This single-center study evaluated the frequency and factors associated with invasive ventilation in infants with acute viral bronchiolitis on a pediatric ward. ■ The study revealed an invasive ventilation rate of 6%, associated with age, presence of atelectasis, and Wood-Downes-Ferres score at admission. ■ Many interventions with poor scientific evidence were used. ■ This study highlights the need to implement clinical protocols for the management of acute viral bronchiolitis, including all levels of care, as these infants are […]

Highlights ■ The return to work rate was 53.7%, with slower and lower reintegration among low-income recipients. ■ Individuals with higher socioeconomic status (Classes A and B) were over twice as likely to return to work compared with lower socioeconomic status. ■ Higher stigma scores were significantly associated with reduced quality of life in Functional Capacity, Mental Health, and Social Functioning domains (p<0.001). ■ Older age (≥51 years), racial disparities, and unemployment before transplantation were strong barriers to occupational reintegration. […]

Highlights ■ Optical coherence tomography enables in vivo characterization of inflammatory activity within coronary plaques. ■ Thin-cap fibroatheromas demonstrate greater macrophage accumulation than non-thin-cap fibroatheromas. ■ Neovascularization is more frequent and quantitatively greater in thin-cap fibroatheromas. ■ The combined burden of macrophages and neovessels provides predictive value for plaque vulnerability. ABSTRACT Objective: The aim of the present study is to assess whether the intensity of local inflammation relates to the presence of thin-cap fibroatheromas. Methods: Retrospective, single-center study of patients […]

Highlights ■ Sex plays a crucial role in behavioral assessments of preclinical study designs. ■ Circadian rhythm influences episodic memory performance in rodent behavior. ■ Spatial memory exhibits fewer variations than locomotion and episodic memory. ■ Sex and the circadian cycle are critical factors in behavioral assessment. ABSTRACT Objective: This study aimed to investigate the effects of sex and time of day on behavioral parameters in healthy rats, focusing on locomotion, cognition, and memory (both spatial and episodic). Methods: Twenty-four […]

Highlights ■ Brazil had a higher upper limb vascular trauma incidence than the US, remaining stable over the years. ■ The region with the highest proportion of cases was the North, followed by the Southeast. ■ The most affected population was young men, with a lethality of 2.37%, comparable to that globally. ■ Most patients did not require intensive care (92.8%), and the average hospital stay was 4.39 days. ABSTRACT Objective: To evaluate the epidemiology of upper limb vascular trauma […]

Highlights ■ All variables that affect the quality of cardiopulmonary resuscitation were analyzed. ■ In addition to performance, we analyzed participants’ confidence. ■ This study considered the cost of training using the traditional methodology versus feedback. ABSTRACT Objective: To analyze cardiopulmonary resuscitation skill acquisition and retention at 3 and 6-month intervals and determine the optimal training frequency and associated costs. Methods: Fifth and sixth-year medical students practiced cardiopulmonary resuscitation using a feedback-equipped simulator. Results: The study included 43 students. Training […]

Highlights ■Most students have a positive attitude towards medical artificial intelligence. ■ Artificial intelligence solutions would be frequently adopted if accurate, fast, and user-friendly. ■ Expectations include work facilitation and increased diagnosis and management speed. ■Most fear losing medical skills to artificial intelligence and desire governmental regulations. ABSTRACT Objective: To assess medical students’ attitudes, knowledge, opinions, and expectations regarding medical artificial intelligence solutions, according to their sex and year of study. Methods: This cross-sectional survey was a single-center study conducted […]