08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/Aug/2025;23:eAO1601.
View Article08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Keywords: Biomarkers; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Lymph nodes; Prognosis; Prostatic neoplasms
30/Jul/2025
Membrane transporter genes predict chemoradiotherapy response in patients with cervical cancer
DOI: 10.31744/einstein_journal/2025AO1154
Highlights ■ Two gene groups with contrasting expression profiles were identified. ■ The ATP1B3 and SLCOB3 gene profiles classified patients with 90% accuracy. ■ The ATP1B3 and SLCOB3 gene signature is a potential predictor of treatment response. ABSTRACT Introduction: Cervical cancer is the fourth most common cancer in women worldwide. Resistance to chemoradiotherapy in cervical cancer has been widely associated with membrane transport-related genes, particularly those encoding efflux transport proteins, such as the ATP-binding cassette family members (including P-glycoprotein), which […]
Keywords: Adenosine triphosphatases; Biomarkers; Carrier proteins; Chemoradiotherapy; Drug resistance, neoplasms; Membrane transport proteins; Solute carrier proteins; Transcriptome; Uterine cervical neoplasms
07/Apr/2025
Comparative analysis of miRNA-mRNA interaction prediction tools based on experimental head and neck cancer data
DOI: 10.31744/einstein_journal/2025AO1372
Highlights ■ miRWalk had the highest predicted interactions and validated miRNA networks in HNSCC. ■ Around 3.3% of interactions overlapped across tools, emphasizing the need for multitool approaches. ■ Dysregulated genes and miRNAs were tied to cancerdriving PI3K-Akt and Wnt pathways. ■ The validated approach highlights the importance of integrating computational and molecular data. ABSTRACT Objective: Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis largely due to late diagnosis and a lack of reliable biomarkers. MicroRNAs (miRNAs), […]
Keywords: Algorithms; Biomarkers; Computational biology; Gene expression; MicroRNAs; Squamous cell carcinoma of head and neck; Target prediction tool
28/Mar/2025
Neuron-specific enolase and Tau protein as biomarkers for sepsis-associated delirium: a cross-sectional pilot study
einstein (São Paulo). 28/Mar/2025;23:eAO1244.
View Article28/Mar/2025
Neuron-specific enolase and Tau protein as biomarkers for sepsis-associated delirium: a cross-sectional pilot study
DOI: 10.31744/einstein_journal/2025AO1244
Highlights ■ Biomarkers of brain injury, such as neuron-specific enolase and Tau proteins, are higher in older patients with sepsis and delirium. ■ Diagnosing sepsis in patients with delirium can be challenging. ■ Early identification of sepsis is key to managing sepsisassociated delirium. ABSTRACT Objective: Sepsis-associated delirium is a common cerebral manifestation in patients with sepsis, potentially caused by a combination of neuroinflammation and other neurophysiological disorders. This study investigated the expression of neuron-specific enolase and Tau protein as biomarkers […]
Keywords: Biomarkers; Delirium; Emergency medicine; Neuroinflammatory diseases; Sepsis
20/Sep/2024
Cluster classification of a Brazilian gastric cancer cohort reveals remarkable populational differences in normal p53 rate
einstein (São Paulo). 20/Sep/2024;22:eAO0508.
View Article20/Sep/2024
Cluster classification of a Brazilian gastric cancer cohort reveals remarkable populational differences in normal p53 rate
DOI: 10.31744/einstein_journal/2024AO0508
ABSTRACT In Brief Queiroz et al. showed that the application of cluster methodology for classifying gastric cancer is suitable and efficient within a Brazilian cohort, which is known for its population heterogeneity. The study highlighted the potential utilization of this method within public health services due to its low-cost, presenting a viable means to improve the diagnosis and prognosis of gastric cancer. Highlights Our Brazilian cohort with gastric cancer has a distinct distribution between mutated and normal p53. New genetic […]
Keywords: Adenocarcinoma; Biomarkers; Cluster analysis; Gastric neoplasms; Genes p53; Genetic heterogeneity; Immunohistochemistry
10/Sep/2024
Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals
DOI: 10.31744/einstein_journal/2024AO0412
Highlights Klotho controls cellular pathways and is a key factor in senescence and longevity. FGF-23 regulates phosphorus and vitamin D metabolism in a Klotho-dependent manner. Bone formation in Klotho-deficient mice decreased similar to that in aged humans. Renal function and lumbar spine bone mineral density were related to Klotho and FGF-23, respectively. ABSTRACT Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals. Methods: A total of 55 individuals […]
Keywords: Aged; Biomarkers; Bone density; FGF-23 protein; Human; Klotho protein; Longevity
24/May/2022
Laboratory variables as predictors of progression in gastroenteropancreatic neuroendocrine tumors in different lines of antineoplastic treatments
einstein (São Paulo). 24/May/2022;20:eAO6985.
View Article24/May/2022
Laboratory variables as predictors of progression in gastroenteropancreatic neuroendocrine tumors in different lines of antineoplastic treatments
DOI: 10.31744/einstein_journal/2022AO6985
ABSTRACT Objective: To determine the association of red cell blood counts, and liver panel tests to predict outcomes in patients with gastroenteropancreatic neuroendocrine tumors who underwent systemic antineoplastic treatments. Methods: Patients with gastroenteropancreatic neuroendocrine tumors in systemic treatment were assessed according to laboratory tests within the same period. Progression free survival was determined by the period between the beginning of treatment and the date of progression. We used conditional models (PWP model) to verify the association between laboratory tests and […]
Keywords: Biomarkers; Blood platelets; Chromogranin A; Gastro-enteropancreatic neuroendocrine tumor; Intention to treat analysis; Lutetium; Neuroendocrine tumors; Neutrophils
23/Feb/2022
MicroRNAs and exosomes: promising new biomarkers in acute myeloid leukemias?
DOI: 10.31744/einstein_journal/2022RB5954
ABSTRACT Despite advances in understanding of carcinogenesis and of treatment of acute myeloid leukemia, this neoplasm still has a lethality of at least 30%. The search for biomarkers that can predict the response to treatment in the early stages of the disease is still necessary. In recent years, a new form of cellular communication between tumor and non-neoplastic cells has been discovered: the exchange of information through extracellular vesicles. These are small vesicles released by membrane-coated cells that carry proteins, […]
Keywords: Biomarkers; Exosomes; Immunomodulation; Leukemia, myeloid, acute; MicroRNAs
08/Jul/2021
MicroRNAs: understanding their role in gene expression and cancer
DOI: 10.31744/einstein_journal/2021RB5996
ABSTRACT MicroRNAs are small RNA molecules that regulate gene expression in cells. These small molecules comprise 17 to 25 nucleotides and are able to recognize target messenger RNAs by sequence complementarity and regulate their protein translation. Different microRNAs are expressed in all human cells. There is over 2,500 microRNAs described in humans that are involved in virtually all biological processes. Given their role as gene expression regulators, these molecules have been widely investigated and are thought to be associated with […]
Keywords: Biomarkers; Gene expression; MicroRNAs; Neoplasms
15/Apr/2021
Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review
DOI: 10.31744/einstein_journal/2021RW5704
ABSTRACT Objective The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. Methods Systematic review conducted on PubMed®, Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE® and Web of Science databases using the search terms endometriosis (all fields) AND miRNA (all fields), evaluating all publication up […]
Keywords: Biomarkers; Body fluids banks; Endometriosis/diagnosis; MicroRNAs; Saliva; Serum; Vaginal fluid