By the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) was identified as the etiologic agent of an outbreak of pneumonia in the city of Wuhan, province of Hubei, in China. The virus had a rapid dissemination, with person-to-person transmission and cases soon identified throughout the world. The disease was called COVID-19 (coronavirus disease 2019), with several new outbreaks related to community transmission. It is now classified as pandemic. – We have observed an […]

Dear authors, We thank you for your kind comments and agree upon the existing doubts about the real meaning of changes in images of the coronavirus disease (COVID-19) in the long term. Some authors bring an extrapolated reflection of other infections, including those related to outbreaks caused by other coronaviruses,() and indicate a potential persistence of some changes in images, including with repercussions in pulmonary function tests more than 10 years after the infectious insult. […]

The primary means of dissemination and sharing of scientific research results are publications in specialized journals. The quality and relevance of the investigation are assessed, among others, by the material that was published, which is usually the single public register of the research. Problems in this communication hinder the correct evaluation of a study and limit its effectiveness. Such a situation becomes critical becomes critical in a research field such as the health sciences, since it allows wrong decisions to […]

Qualitative research articles are different from the usual research publications in medicine and biological sciences,() given hypotheses are raised after data collection. The aim is to gain insights into and give voice to patients’ or persons’ experiences. The hypothesis can be altered along the way, which is impossible in most studies in Medicine. Surveys are often used in quantitative studies and can be combined with qualitative methods, such as in-depth interviews with small samples. Qualitative research is mostly based on […]

SALUTOGENESIS AND SENSE OF COHERENCE Salutogenesis is the approach proposed by Antonovsky() to guide his investigation and the scientific development of the field of health promotion. Based on a critical evaluation of the development of this field – which, due to a lack of a consistent theoretical model with stated objectives, in general, adopts the paradigm of pathogenesis as reference –, a new model is proposed, focusing on elements that maintain and enhance health, that is, on the “health protective […]

Factors that influence the placebo and nocebo effects These effects are influenced by external factors or environmental, in addition to internal or personal factors. The cascade of events that trigger the nocebo and placebo responses begins by internal commands and suggestions of the mind, and advances as the person develops these commands, which can transform into signs and symptoms of a disease. The emotional status, personal and humor characteristics, cognition and personality of the individual, and female sex – which […]

Healthcare professionals practice their activities daily with dedication and informed by science, and face several situations of excessively complex care. Nobel, courageous, and full of compassion, they increasingly want to save more lives, be useful; with the objective of achieving better results in care, they bravely face long working hours with no sleep, and are known as professionals that dedicate themselves constantly in work as in studies. Additionally, they have a method of working that requires physical disposition and agility […]

The International Society on Thrombosis and Haemostasis (ISTH) has proposed a new category to detect the earlier phase of sepsis-associated disseminated intravascular coagulation (DIC), called sepsis-induced coagulopathy. The criteria included platelet count, prothrombin time and Sequential Organ Failure Assessment (SOFA) score.() Patients with sepsis and extensive forms of DIC may develop overt thromboembolic complications, or clinically less apparent microvascular clot formation that may contribute to multiple organ failure.() Activation of the vascular endothelium, platelets, and leukocytes results in dysregulated thrombin […]

ABSTRACT The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition […]

ABSTRACT Randomized controlled trials are known to be the best tool to determine the effects of an intervention; however, most healthcare professionals are not able to adequately understand the results. In this report, concepts, applications, examples, and advantages of using visual data as a complementary tool in the results section of original articles are presented. Visual simplification of data presentation will improve general understanding of clinical research.

ABSTRACT The Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease was approved by Sociedade Brasileira de Transplante de Medula Óssea , with the participation of 26 Brazilian hematopoietic stem cell transplantation centers. It describes the main nutritional protocols in cases of Graft- versus -host disease, the main complication of hematopoietic stem cell transplantation.

INTRODUCTION Many are the uncertainties generated by the potential healthcare resource scarcity in the face of a relevant increase in the number of cases of coronavirus disease 2019 (COVID-19), an infectious disease caused by the novel coronavirus (SARS-CoV-2) of the Coronaviridae family. The virus emerged in China, in December 2019, spreading rapidly to other regions of the world, including Brazil. Since March 11, 2020, COVID-19 has been considered a pandemic by the World Health Organization (WHO). Viral pandemics tend to […]

ABSTRACT In December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a new betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 20% of patients diagnosed as COVID-19 develop severe forms of the disease, including acute hypoxemic respiratory failure, severe acute respiratory syndrome, acute respiratory distress syndrome and acute renal failure and require intensive care. […]

ABSTRACT Objective To evaluate the oxidative profile, nutritional status and food intake (caloric value; macronutrients; vitamins A, E and C; and zinc), and to correlate oxidative stress with nutritional status in patients who were candidates for liver transplant. Methods This is a cross-sectional, analytical, and descriptive study with 51 candidates for liver transplant. Sociodemographic and clinical data, anthropometric parameters, food consumption, and a 10mL blood sample were collected from each patient. Oxidative stress was analyzed by the thiobarbituric acid method. […]

ABSTRACT Objective To determine the association between the presence of periodontal pathogens and low birthweight. Methods This observational and case-control study consisted of mothers of infants weighing

ABSTRACT Objective To compare the chest tube drainage by the same thoracotomy intercostal space with the traditional approach in patients undergoing muscle-sparing thoracotomy. Methods We evaluated 40 patients aged ≥18 years who underwent elective muscle sparing thoracotomies. Patients were divided into two groups of 20 patients. One group underwent thoracic drainage by the same intercostal space of thoracotomy and the other by traditional chest drainage approach. Results The mean length of hospital stay for the intercostal drainage group in the […]

ABSTRACT Objective: To describe the pharmaceutical interventions of a vertical clinical pharmacy service to promote the rational use of intravenous omeprazole. Methods: A prospective and descriptive study carried out at a university hospital in the Midwestern Region of Brazil, from November 2014 to May 2015. The service consisted of the analysis of adequacy of the route of administration of omeprazole in relation to the clinical conditions of the patient, as well as the use of the appropriate diluent. Interventions were […]

ABSTRACT Objective To analyze the characteristics of patients with hypertension and/or diabetes mellitus from Primary Healthcare units. Methods This is a retrospective study, with data collected from December 2014 of patients with hypertension and/or diabetes from 13 Primary Healthcare units located in the Southern region of Sao Paulo (SP, Brazil). Patients were compared by sex, diagnosis and cardiovascular risk using student t test, one way analysis of variance (ANOVA), and Mann-Whitney, Kruskal-Wallis and χ2 tests. Results We evaluated 28,496 patients […]

ABSTRACT Objective To investigate if ICI 182,780 (fulvestrant), a selective estrogen receptor alpha/beta (ERα/ERβ) antagonist, and G-1, a selective G-protein-coupled receptor (GPER) agonist, can potentially induce autophagy in breast cancer cell lines MCF-7 and SKBr3, and how G-1 affects cell viability. Methods Cell viability in MCF-7 and SKBr3 cells was assessed by the MTT assay. To investigate the autophagy flux, MCF-7 cells were transfected with GFP-LC3, a marker of autophagosomes, and analyzed by real-time fluorescence microscopy. MCF-7 and SKBr3 cells […]

ABSTRACT Objective To determine the occurrence of anti-tuberculosis drug resistance and its association with sociodemographic and clinical characteristics of patients in a referral hospital. Methods This was a cross-sectional study based on data from patients who had mycobacterial culture identified and defined antimicrobials sensitivity profile (June 2014 to February 2016). The descriptive statistical analysis and Fisher’s exact test were used to compare proportions. Results The study included 104 patients who had positive results for Mycobacterium tuberculosis . Bacilloscopy had high […]