58 results

Should we treat fever in critically ill patients? A summary of the current evidence from three randomized controlled trials

Ary Serpa Neto, Victor Galvão Moura Pereira, Giancarlo Colombo, Farah Christina de la Cruz Scarin, Camila Menezes Souza Pessoa, Leonardo Lima Rocha

DOI: 10.1590/S1679-45082014RW2785

Fever is a nonspecific response to various types of infectious or non-infectious insult and its significance in disease remains an enigma. Our aim was to summarize the current evidence for the use of antipyretic therapy in critically ill patients. We performed systematic review and meta-analysis of publications from 1966 to 2013. The MEDLINE and CENTRAL databases were searched for studies on antipyresis in critically ill patients. The meta-analysis was limited to: randomized controlled trials; adult human critically ill patients; treatment […]

Personalized medicine and the clinical laboratory

João Renato Rebello Pinho, Roberta Sitnik, Cristóvão Luis Pitangueira Mangueira

DOI: 10.1590/s1679-45082014rw2859

Personalized medicine is the use of biomarkers, most of them molecular markers, for detection of specific genetic traits to guide various approaches for preventing and treating different conditions. The identification of several genes related to heredity, oncology and infectious diseases lead to the detection of genetic polymorphisms that are involved not only in different clinical progression of these diseases but also in variations in treatment response. Currently, it is possible to detect these polymorphisms using several methodologies: detection of single […]

Scales on Quality of Life in patients with spinal cord injury: integrative review

Rita Lacerda Aquarone, Ana Cristina Mancussi e Faro

DOI: 10.1590/S1679-45082014RW2591

Studies evaluating the Quality of Life of individuals with spinal cord injury using different research tools demonstrate that the Quality of Life scores are considered low both in national and international studies. The objective of this review was to characterize the international scientific production about the most used scales to assess Quality of Life in patients with spinal cord injury. We examined articles on Quality of Life of patients with spinal cord injury published over the last 5 years and […]

Antiretroviral drugs and acute pancreatitis in HIV/AIDS patients: is there any association? A literature review

Natalia Mejias Oliveira, Felipe Augusto Yamauti Ferreira, Raquel Yumi Yonamine, Ethel Zimberg Chehter

DOI: 10.1590/S1679-45082014RW2561

In HIV-seropositive individuals, the incidence of acute pancreatitis may achieve 40% per year, higher than the 2% found in the general population. Since 1996, when combined antiretroviral therapy, known as HAART (highly active antiretroviral therapy), was introduced, a broad spectrum of harmful factors to the pancreas, such as opportunistic infections and drugs used for chemoprophylaxis, dropped considerably. Nucleotide analogues and metabolic abnormalities, hepatic steatosis and lactic acidosis have emerged as new conditions that can affect the pancreas. To evaluate the […]

Obesity and lung function: a systematic review

Luciana Costa Melo, Maria Alayde Mendonça da Silva, Ana Carolina do Nascimento Calles

DOI: 10.1590/S1679-45082014RW2691

Obesity is a chronic disease characterized by the excessive accumulation of body fat that is harmful to the individuals. Respiratory disorders are among the comorbidities associated with obesity. This study had the objective of investigating the alterations in respiratory function that affect obese individuals. A systematic review was performed, by selecting publications in the science databases MEDLINE and LILACS, using PubMed and SciELO. The articles that assessed pulmonary function by plethysmography and/or spirometry in obese individuals aged under 18 years […]

Swallowing sounds in speech therapy practice: a critical analysis of the literature

Juliana Lopes Ferrucci, Laura Davison Mangilli, Fernanda Chiarion Sassi, Suelly Cecilia Olivan Limongi, Claudia Regina Furquim de Andrade

DOI: 10.1590/S1679-45082013000400024

This study aimed to investigate international scientific papers published on the subject of cervical auscultation and its use in speech therapy. The study involved a qualitative review of the literature spanning the last 10 years. Articles were selected from the PubMed database using the following keywords: cervical auscultation, swallowing and swallowing disorders. Research was included that was conducted on adult humans (over 18 years of age) and was written in English. Each citation retrieved from the database was analyzed independently […]

Decompensated heart failure

Sandrigo Mangini, Philippe Vieira Pires, Fabiana Goulart Marcondes Braga, Fernando Bacal

DOI: 10.1590/S1679-45082013000300022

Heart failure is a disease with high incidence and prevalence in the population. The costs with hospitalization for decompensated heart failure reach approximately 60% of the total cost with heart failure treatment, and mortality during hospitalization varies according to the studied population, and could achieve values of 10%. In patients with decompensated heart failure, history and physical examination are of great value for the diagnosis of the syndrome, and also can help the physician to identify the beginning of symptoms, […]

Vascular calcification: pathophysiology and clinical implications

Marcel Liberman, Antonio Eduardo Pereira Pesaro, Luciana Simão Carmo, Carlos Vicente Serrano Jr

DOI: 10.1590/S1679-45082013000300021

Vascular calcification in coronary artery disease is gaining importance, both in scientific research and in clinical and imaging applications. The calcified plaque is considered the most relevant form of atherosclerosis within the coronary artery tree and is frequently a challenge for percutaneous intervention. Recent studies showed that plaque calcification is dynamic and is strictly related to the degree of vascular inflammation. Several inflammatory factors produced during the different phases of atherosclerosis induce the expression and activation of osteoblastic cells located […]

Current data on IL-17 and Th17 cells and implications for graft versus host disease

Marília Normanton, Luciana Cavalheiro Marti

DOI: 10.1590/S1679-45082013000200019

Human interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of organisms against extracellular bacteria and fungi due to the capacity of IL-17A to recruit neutrophils to the areas of infection, evidencing a pathological role in various models of autoimmune diseases, such […]

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