56 results

Oral care and nosocomial pneumonia: a systematic review

Maria Carolina Nunes Vilela, Gustavo Zanna Ferreira, Paulo Sérgio da Silva Santos, Nathalie Pepe Medeiros de Rezende

DOI: 10.1590/S1679-45082015RW2980

To perform a systematic review of the literature on the control of oral biofilms and the incidence of nosocomial pneumonia, in addition to assessing and classifying studies as to the grade of recommendation and level of evidence. The review was based on PubMed, LILACS, and Scopus databases, from January 1st, 2000 until December 31st, 2012. Studies evaluating oral hygiene care related to nosocomial infections in patients hospitalized in intensive care units were selected according to the inclusion criteria. Full published […]

Hypodermoclysis: a literature review to assist in clinical practice

Vanessa Galuppo Bruno

DOI: 10.1590/S1679-45082015RW2572

The aim of this study was to analyze the information available in the literature about the drugs that can be administered through hypodermoclysis and the resulting impact that this information may have on the routine of the pharmacist working at a hospital. The study was based on a review of the literature. The results showed positive points of the procedure, but little specific information about medications such as routes of administration, standard dilutions, optimal doses, etc. Thus, it was possible […]

Association between increased serum thyrotropin concentration and the oldest old: what do we know?

Glaucia Cruzes Duarte, Maysa Seabra Cendoroglo, Lara Miguel Quirino Araújo, Clineu de Mello Almada Filho

DOI: 10.1590/S1679-45082015RW2874

To assess studies that evaluate the relation between serum thyrotropin concentration, very old subjects, and their events. We searched the PubMed, SciELO, and LILACS databases for articles published between 2004 and 2012. Our search was restricted to studies involving humans aged 65 years or older, and written in English, Spanish, or Portuguese. Studies that evaluated the association between elevated serum thyrotropin concentration among elderly subjects with subclinical hypothyroidism were chosen since at least in part they included a subpopulation of […]

Ischemia and reperfusion injury in renal transplantation: hemodynamic and immunological paradigms

Lúcio Roberto Requião-Moura, Marcelino de Souza Durão Junior, Ana Cristina Carvalho de Matos, Alvaro Pacheco-Silva

DOI: 10.1590/S1679-45082015RW3161

Ischemia and reperfusion injury is an inevitable event in renal transplantation. The most important consequences are delayed graft function, longer length of stay, higher hospital costs, high risk of acute rejection, and negative impact of long-term follow-up. Currently, many factors are involved in their pathophysiology and could be classified into two different paradigms for education purposes: hemodynamic and immune. The hemodynamic paradigm is described as the reduction of oxygen delivery due to blood flow interruption, involving many hormone systems, and […]

Cytomegalovirus infection in renal transplantation: clinical aspects, management and the perspectives

Lúcio Roberto Requião-Moura, Ana Cristina Carvalho de Matos, Alvaro Pacheco-Silva

DOI: 10.1590/S1679-45082015RW3175

Cytomegalovirus infection is one of most frequent infectious complications after renal transplantation, and can be classified as primo-infection, when the transmission occurs through the graft, or reactivation, when the recipient is cytomegalovirus seropositive. After transplantation, cytomegalovirus can appear as an infection, when the patient presents with evidence of viral replication without symptoms or disease, which has two clinical spectra: typical viral syndrome or invasive disease, which is a less common form. Their effects can be classified as direct, while the […]

Liver transplantation: history, outcomes and perspectives

Roberto Ferreira Meirelles Júnior, Paolo Salvalaggio, Marcelo Bruno de Rezende, Andréia Silva Evangelista, Bianca Della Guardia, Celso Eduardo Lourenço Matielo, [...]

DOI: 10.1590/S1679-45082015RW3164

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two […]

Intestinal and multivisceral transplantation

Sérgio Paiva Meira Filho, Bianca Della Guardia, Andréia Silva Evangelista, Celso Eduardo Lourenço Matielo, Douglas Bastos Neves, Fernando Luis Pandullo, [...]

DOI: 10.1590/S1679-45082015RW3155

Intestinal transplantation has shown exceptional growth over the past 10 years. At the end of the 1990’s, intestinal transplantation moved out of the experimental realm to become a routine practice in treating patients with severe complications related to total parenteral nutrition and intestinal failure. In the last years, several centers reported an increasing improvement in survival outcomes (about 80%), during the first 12 months after surgery, but long-term survival is still a challenge. Several advances led to clinical application of […]

Perioperative hypothermia and incidence of surgical wound infection: a bibliographic study

Aline Batista da Silva, Aparecida de Cassia Giani Peniche

DOI: 10.1590/S1679-45082014RW2398

The purpose of this review article was to understand and analyze the scientific production related to the occurrence of perioperative hypothermia and the incidence of infection on the surgical site. For this purpose, a search was conducted in the databases LILACS, MEDLINE, PubMed, CINAHL and Cochrane, using the health science descriptors DECS, from 2004 to 2009. A total of 91 articles were found. After eliminating duplicate items and using selection criteria for inclusion, six manuscripts remained for analysis. The studies […]

Should we treat fever in critically ill patients? A summary of the current evidence from three randomized controlled trials

Ary Serpa Neto, Victor Galvão Moura Pereira, Giancarlo Colombo, Farah Christina de la Cruz Scarin, Camila Menezes Souza Pessoa, Leonardo Lima Rocha

DOI: 10.1590/S1679-45082014RW2785

Fever is a nonspecific response to various types of infectious or non-infectious insult and its significance in disease remains an enigma. Our aim was to summarize the current evidence for the use of antipyretic therapy in critically ill patients. We performed systematic review and meta-analysis of publications from 1966 to 2013. The MEDLINE and CENTRAL databases were searched for studies on antipyresis in critically ill patients. The meta-analysis was limited to: randomized controlled trials; adult human critically ill patients; treatment […]

Personalized medicine and the clinical laboratory

João Renato Rebello Pinho, Roberta Sitnik, Cristóvão Luis Pitangueira Mangueira

DOI: 10.1590/s1679-45082014rw2859

Personalized medicine is the use of biomarkers, most of them molecular markers, for detection of specific genetic traits to guide various approaches for preventing and treating different conditions. The identification of several genes related to heredity, oncology and infectious diseases lead to the detection of genetic polymorphisms that are involved not only in different clinical progression of these diseases but also in variations in treatment response. Currently, it is possible to detect these polymorphisms using several methodologies: detection of single […]

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