07/Apr/2025
Comparative analysis of miRNA-mRNA interaction prediction tools based on experimental head and neck cancer data
DOI: 10.31744/einstein_journal/2025AO1372
Highlights ■ miRWalk had the highest predicted interactions and validated miRNA networks in HNSCC. ■ Around 3.3% of interactions overlapped across tools, emphasizing the need for multitool approaches. ■ Dysregulated genes and miRNAs were tied to cancerdriving PI3K-Akt and Wnt pathways. ■ The validated approach highlights the importance of integrating computational and molecular data. ABSTRACT Objective: Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis largely due to late diagnosis and a lack of reliable biomarkers. MicroRNAs (miRNAs), […]
Keywords: Algorithms; Biomarkers; Computational biology; Gene expression; MicroRNAs; Squamous cell carcinoma of head and neck; Target prediction tool
30/Jan/2024
A molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway
DOI: 10.31744/einstein_journal/2024RW0552
ABSTRACT Introduction Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This phenotype renders triple-negative breast cancer cells refractory to conventional therapies, resulting in poor clinical outcomes and an urgent need for novel therapeutic approaches. Recent studies have implicated dysregulation of the Notch receptor signaling pathway in the development and progression of triple-negative breast cancer. Objective This study aimed to conduct a […]
Keywords: Cell proliferation; MicroRNAs; Molecular targeted therapy; Notch1; Receptors; Signal transduction; Triple-negative breast neoplasms
23/Feb/2022
MicroRNAs and exosomes: promising new biomarkers in acute myeloid leukemias?
DOI: 10.31744/einstein_journal/2022RB5954
ABSTRACT Despite advances in understanding of carcinogenesis and of treatment of acute myeloid leukemia, this neoplasm still has a lethality of at least 30%. The search for biomarkers that can predict the response to treatment in the early stages of the disease is still necessary. In recent years, a new form of cellular communication between tumor and non-neoplastic cells has been discovered: the exchange of information through extracellular vesicles. These are small vesicles released by membrane-coated cells that carry proteins, […]
Keywords: Biomarkers; Exosomes; Immunomodulation; Leukemia, myeloid, acute; MicroRNAs
08/Jul/2021
MicroRNAs: understanding their role in gene expression and cancer
DOI: 10.31744/einstein_journal/2021RB5996
ABSTRACT MicroRNAs are small RNA molecules that regulate gene expression in cells. These small molecules comprise 17 to 25 nucleotides and are able to recognize target messenger RNAs by sequence complementarity and regulate their protein translation. Different microRNAs are expressed in all human cells. There is over 2,500 microRNAs described in humans that are involved in virtually all biological processes. Given their role as gene expression regulators, these molecules have been widely investigated and are thought to be associated with […]
Keywords: Biomarkers; Gene expression; MicroRNAs; Neoplasms
15/Apr/2021
Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review
DOI: 10.31744/einstein_journal/2021RW5704
ABSTRACT Objective The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. Methods Systematic review conducted on PubMed®, Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE® and Web of Science databases using the search terms endometriosis (all fields) AND miRNA (all fields), evaluating all publication up […]
Keywords: Biomarkers; Body fluids banks; Endometriosis/diagnosis; MicroRNAs; Saliva; Serum; Vaginal fluid
01/Apr/2014
Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
DOI: 10.1590/S1679-45082014MD2839
Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics […]
Keywords: Biological markers; Colorectal neoplasms/chemotherapy; Combined modality therapy; MicroRNAs; Treatment outcome