4 results

Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Silmara Cristiane da Silveira Andreoli, Nina Jardim Gasparini, Gisele Pereira de Carvalho, Bernardo Garicochea, Robert Edward Pogue, Rosângela Vieira de Andrade

DOI: 10.1590/S1679-45082014MD2839

Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics […]

Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects

Ary Serpa Neto, Felipe Martin Bianco Rossi, Rodrigo Dal Moro Amarante, Marçal Rossi

DOI: 10.1590/s1679-45082011ao2042

ABSTRACTObjectives:To evaluate the relations between liver markers (GGT, ALT and AST) and the metabolic syndrome (and its components) in morbidly obese subjects, and to determine the response of these metabolic factors and hepatic enzymes after weight loss induced by Roux-en-Y gastric bypass.Methods:This study was carried out at a university hospital, in Santo André (SP), Brazil. We evaluated 140 morbidly obese subjects aged from 18 to 60 years submitted to a Roux-en-Y gastric bypass, who were followed for a mean period […]

Effects of dietary fiber intake on inflammation in chronic diseases

Ana Maria Pita Lottenberg, Patricia Luriko Tomita Fan, Vivian Buonacorso

DOI: 10.1590/s1679-45082010md1310

ABSTRACTChronic diseases such as obesity, type-2 diabetes, metabolic syndrome and cardiovascular diseases are associated with inflammation due the increase of TNF-α, IL-6 and C-reactive protein concentrations. Occidental life style, specially related to the changes in food habits as observed in the past years, have an important role in the development of these diseases. Among the life style changes identified as having an impact in the development of diseases, is the decrease in dietary fiber consumption. Some studies have shown the […]

Relation between three-dimensional and two-dimensional echocardiography and biochemical analysis in patients with ST-segment elevation myocardial infarction percutaneously treated

Marcelo Luiz Campos Vieira, Wercules Antônio Oliveira, Alexandre Ferreira Cury, Adriana Cordovil, Ana Clara Tude Rodrigues, Gustavo Alberto Frazatto Naccarato, [...]

DOI: 10.1590/s1679-45082010ao1438

ABSTRACTObjective:The prognosis of patients with acute myocardial infarction depends on multiple features that can demonstrate myocardial injury degree (such as serum markers of cardiac necrosis), and also on adaptive mechanisms relative to the acute event. The aim of the study was to assess the relation between biochemical and echocardiographic findings from three-dimensional echocardiographic (3D Echo) analysis and echocardiographic two-dimensional (2D Echo) left ventricular ejection fraction in patients with ST-segment elevation acute myocardial infarction, submitted to primary percutaneous treatment.Methods:A prospective study […]