3 results

Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration

Renato Carneiro de Freitas Chaves ORCID logo , Philipe Franco do Amaral Tafner ORCID logo , Felipe Ko Chen ORCID logo , Letícia Bagatini Meneghini ORCID logo , Thiago Domingos Corrêa ORCID logo , Roberto Rabello Filho ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4439

ABSTRACT Objective To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury. Methods A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Vascular occlusion test was performed on the forearm to be submitted to near-infrared spectroscopy […]

How to choose the therapeutic goals to improve tissue perfusion in septic shock

Murillo Santucci Cesar de Assuncao, Thiago Domingos Corrêa, Bruno de Arruda Bravim, Eliézer Silva

DOI: 10.1590/S1679-45082015RW3148

The early recognition and treatment of severe sepsis and septic shock is the key to a successful outcome. The longer the delay in starting treatment, the worse the prognosis due to persistent tissue hypoperfusion and consequent development and worsening of organ dysfunction. One of the main mechanisms responsible for the development of cellular dysfunction is tissue hypoxia. The adjustments necessary for adequate tissue blood flow and therefore of oxygen supply to metabolic demand according to the assessment of the cardiac […]

Role of insulin hormone in modulation of inflammatory phenomena

Antonio Di Petta

DOI: 10.1590/s1679-45082011rb1564

ABSTRACTEvidence demonstrates the involvement of hormones in the development of inflammatory response. Inflammation evokes marked structural alterations of microvasculature, besides migration of leukocytes from microcirculation to the site of lesion. These alterations are caused primarily by release or activation of endogenous mediators, in which hormones play an integral role in this regulatory system. Binding sites for many hormones may be characterized by vascular structures and hematogenous cells involved with the inflammatory response. Quantitative alterations of inflammatory events involving the decrease […]