All publications of “Murillo Santucci Cesar de Assuncao”

3 results

How to choose the therapeutic goals to improve tissue perfusion in septic shock

Murillo Santucci Cesar de Assuncao, Thiago Domingos Corrêa, Bruno de Arruda Bravim, Eliézer Silva

DOI: 10.1590/S1679-45082015RW3148

The early recognition and treatment of severe sepsis and septic shock is the key to a successful outcome. The longer the delay in starting treatment, the worse the prognosis due to persistent tissue hypoperfusion and consequent development and worsening of organ dysfunction. One of the main mechanisms responsible for the development of cellular dysfunction is tissue hypoxia. The adjustments necessary for adequate tissue blood flow and therefore of oxygen supply to metabolic demand according to the assessment of the cardiac […]

Fluid therapy for septic shock resuscitation: which fluid should be used?

Thiago Domingos Corrêa, Leonardo Lima Rocha, Camila Menezes Souza Pessoa, Eliézer Silva, Murillo Santucci Cesar de Assuncao

DOI: 10.1590/S1679-45082015RW3273

Early resuscitation of septic shock patients reduces the sepsis-related morbidity and mortality. The main goals of septic shock resuscitation include volemic expansion, maintenance of adequate tissue perfusion and oxygen delivery, guided by central venous pressure, mean arterial pressure, mixed or central venous oxygen saturation and arterial lactate levels. An aggressive fluid resuscitation, possibly in association with vasopressors, inotropes and red blood cell concentrate transfusion may be necessary to achieve those hemodynamic goals. Nonetheless, even though fluid administration is one of […]