2 results

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

Bárbara Festa Gomes ORCID logo , Camila de Melo Accardo ORCID logo

DOI: 10.31744/einstein_journal/2019RB4596

ABSTRACT Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators – called adipokines – on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist […]

Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice

Rodolfo Marinho, Leandro Pereira de Moura, Bárbara de Almeida Rodrigues, Luciana Santos Souza Pauli, Adelino Sanchez Ramos da Silva, Eloize Cristina Chiarreotto Ropelle, [...]

DOI: 10.1590/S1679-45082014AO2881

Objective:To investigate the effects of different intensities of acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice.Methods: Swiss mice were randomly divided into four groups, and fed either a standard diet (control group) or high fat diet (obese sedentary group and obese exercise group 1 and 2) for 12 weeks. Two different exercise protocols were used: swimming for 1 hour with or without an overload of 5% body weight. The insulin tolerance test […]