einstein (São Paulo). 19/Feb/2019;17(1):eRB4596.

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

Bárbara Festa Gomes ORCID logo , Camila de Melo Accardo ORCID logo

DOI: 10.31744/einstein_journal/2019RB4596

ABSTRACT

Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators – called adipokines – on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist in the protection of pancreatic ß cells from the damages arising from oxidative stress and inflammatory process, in order to control the hyperglycemic picture, which is characteristic of diabetes mellitus.

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

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