6 results
21/Nov/2018
21/Nov/2018
DOI: 10.31744/einstein_journal/2018AO4278
ABSTRACT Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. Methods: A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3+ T cell or total lymphocyte counts in peripheral blood. Results: A total of 664 paired samples were […]
Keywords: Immunosuppression; Kidney transplantation; Monitoring, immunologic; Receptor-CD3 complex, antigen, T-cell; T-lymphocytes
01/Apr/2017
DOI: 10.1590/S1679-45082017AO3992
ABSTRACT Objective To evaluate retinal changes in patients who underwent solid organ or bone marrow transplantation. Methods A retrospective analysis of medical records of patients evaluated from February 2009 to December 2016. All patients included underwent funduscopy. Clinical and demographic data regarding transplantation and ophthalmological changes were collected. Results A total of 126 patients were analyzed; of these, 108 underwent transplantation and 18 were in the waiting list. Transplantation modalities were heart, lung, kidney, liver, pancreas, combined pancreas and kidney […]
Keywords: Bone marrow transplantation; Central serous chorioretinopathy; Diabetic retinopathy; Immunosuppression; Transplantation
01/Jan/2016
DOI: 10.1590/S1679-45082016AO3490
ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, […]
Keywords: Immunosuppression; Lupus eryithematosus; systemic/complications; Urinary tract infection/etiology
01/Apr/2015
01/Apr/2015
DOI: 10.1590/S1679-45082015RW3163
ABSTRACT Vascularized pancreas transplantation is the only treatment that establishes normal glucose levels and normalizes glycosylated hemoglobin levels in type 1 diabetic patients. The first vascularized pancreas transplant was performed by William Kelly and Richard Lillehei, to treat a type 1 diabetes patient, in December 1966. In Brazil, Edison Teixeira performed the first isolated segmental pancreas transplant in 1968. Until the 1980s, pancreas transplants were restricted to a few centers of the United States and Europe. The introduction of tacrolimus […]
Keywords: Diabetes mellitus; Immunosuppression; Pancreas transplantation; Renal insufficiency
01/Jan/2015
DOI: 10.1590/S1679-45082015RW3164
In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two […]
Keywords: Brazil; Immunosuppression; Liver cirrhosis; Liver transplantation/history; Organ preservation; Tissue and organ procurement; Tissue donors
01/Oct/2010
DOI: 10.1590/S1679-45082010MD1716
ABSTRACT Pancreas transplantation is the only treatment able to reestablish normal glucose and glycated hemoglobin levels in insulin-dependent diabetic patients without the use of exogenous insulin. The evolution of pancreas transplantation in treatment of diabetes was determined by advances in the fields of surgical technique, organ preservation and immunosuppressants. The main complication leading to graft loss is technical failure followed by acute or chronic rejection. Technical failure means graft loss within the first three months following transplantation due to vascular […]
Keywords: Immunosuppression; Islets of Langerhans transplantation; Pancreas transplantation/adverse effects