einstein (São Paulo). 21/Nov/2018;16(4):eAO4278.

Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts

Fabiani Palagi Machado ORCID logo , Alessandra Rosa Vicari ORCID logo , Fábio Spuldaro ORCID logo , João Batista Saldanha de Castro Filho ORCID logo , Roberto Ceratti Manfro ORCID logo

DOI: 10.31744/einstein_journal/2018AO4278

ABSTRACT

Objective:

To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes.

Methods:

A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3+ T cell or total lymphocyte counts in peripheral blood.

Results:

A total of 664 paired samples were analyzed. The Spearman’s correlation coefficient was 0.416 (p<0.001) for all samples combined; the overall Kappa coefficient was 0.267 (p<0.001). Diagnostic parameters estimated based on total lymphocyte counts were also calculated using the number of CD3+ T cells (gold standard), with a cut off of >20 cells/mm3.

Conclusion:

Total lymphocyte and CD3+ T cell counts in peripheral blood are not equivalent monitoring strategies in anti-thymocyte globulin therapy.

Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts

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