A new experimental model for inducing interstitial cystitis by oxidative stress using intravesical instillation of a nitric oxide donor gel
ABSTRACTObjective:The aim of this study was to develop an experimental model of inducing interstitial cystitis through intravesical instillation of a polymeric solution containing the NO donor S-nitrousglutathione (GSNO) and to compare it to the experimental interstitial cystitis induced by vesical instillation of protamine and potassium chloride.Methods:A total of 40 female Wistar rats were used and divided into four groups: 1 – ten rats treated with saline solution + GSNO; 2 – ten rats treated with saline solution + polymeric solution […]
Autoimmune uveitis: study of treatment therapies
ABSTRACTExperimental autoimmune uveitis is an organ-specific T-cell mediated autoimmune disease characterized by inflammation and consequent destruction of the neural retina and adjacent tissues. Inflammation in experimental autoimmune uveitis may be induced in rodents by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein. We present a review of experimental studies that correlate primary immunobiological functions with this chronic disease and the possible use of molecules for the treatment of autoimmune uveitis.
Modification of the gasless fetoscopy technique for the treatment of large myelomeningocele: a study in sheep
ABSTRACTObjective:To change the gasless fetoscopy technique in order to reduce the diameter of entry orifices in the myometrium.Methods:Seven pregnant ewes were submitted to fetoscopy for repairing a large skin defect measuring 4.0 × 3.0 cm, created in the fetal lumbar region at the gestational age of 100 days. The defect was repaired through continuous suture of the skin with approximation of borders. Gasless fetoscopy was used for performing the suture with three orifices to allow entry of the trocar into […]