All publications of “Márcia Lanzoni de Alvarenga”

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A new experimental model for inducing interstitial cystitis by oxidative stress using intravesical instillation of a nitric oxide donor gel

Thais Figueiredo Palma, Márcia Lanzoni de Alvarenga, Amedea Barozzi Seabra, Marcelo Ganzarolli de Oliveira, Cássio Luis Zanettini Riccetto

DOI: 10.1590/s1679-45082010ao1663

ABSTRACTObjective:The aim of this study was to develop an experimental model of inducing interstitial cystitis through intravesical instillation of a polymeric solution containing the NO donor S-nitrousglutathione (GSNO) and to compare it to the experimental interstitial cystitis induced by vesical instillation of protamine and potassium chloride.Methods:A total of 40 female Wistar rats were used and divided into four groups: 1 – ten rats treated with saline solution + GSNO; 2 – ten rats treated with saline solution + polymeric solution […]