einstein (São Paulo). 01/Oct/2010;8(4 Pt 1):444-8.

Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation

Mário Benjamin Goitia-Durán, Marcelo Moura Linhares, Ricardo Artigiani Neto, Franz Robert Apodaca-Torrez, Edson José Lobo, Alberto Goldenberg

DOI: 10.1590/S1679-45082010AO1655

ABSTRACT

Objective:

To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation.

Methods:

Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in paraffin embedded tumor blocks. The relation of these expressions with different variables was studied.

Results:

Ninety-three per cent of tumors showed expression of p53 and p16. Ki-67 was expressed in 86.66% of tumors (labeling index – LI 11.91 ± 9.47). The presence of combined alterations was not related to significant differences in tumor type, stage or survival; similar results were obtained analyzing isolated expressions. When groups of p16 and Ki-67 expressions where created, the median survival was not significant. However, there was a slightly better survival in patients with focal expression of p16 (median survival 20.75 versus 14.34), when compared to patients with diffuse expression.

Conclusion:

The overexpression of p53, p16 and Ki-67 was not related to survival or tumor grade, when comparing isolated or combined expressions.

Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation

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