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Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation

Mário Benjamin Goitia-Durán, Marcelo Moura Linhares, Ricardo Artigiani Neto, Franz Robert Apodaca-Torrez, Edson José Lobo, Alberto Goldenberg

DOI: 10.1590/S1679-45082010AO1655

ABSTRACT Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in paraffin embedded tumor blocks. The relation of these expressions with different variables was studied. Results: Ninety-three per cent of tumors showed expression of p53 and p16. Ki-67 was expressed in 86.66% of tumors (labeling index – LI 11.91 ± 9.47). The presence of combined alterations […]