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Experimental autoimmune uveitis is an organ-specific T-cell mediated autoimmune disease characterized by inflammation and consequent destruction of the neural retina and adjacent tissues. Inflammation in experimental autoimmune uveitis may be induced in rodents by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein. We present a review of experimental studies that correlate primary immunobiological functions with this chronic disease and the possible use of molecules for the treatment of autoimmune uveitis.
CommodaroAG, MoraesLDV, TambourgiDV, Belfort Jr.R, Sant’AnnaOA, RizzoLV. Autoimmune uveitis: study of treatment therapies. Einstein (Sao Paulo). 2010;8(1):117-21. https://doi.org/10.1590/S1679-45082010RB1416
Commodaro,Alessandra Gonçalves; Moraes,Luciana de Deus Vieira de; Tambourgi,Denise Vilarinho; Belfort Jr.,Rubens; Sant’Anna,Osvaldo Augusto; Rizzo,Luiz Vicente. Autoimmune uveitis: study of treatment therapies. Einstein (Sao Paulo)., v. 8, n. 1, p. 117-121, Jan. 2010. https://doi.org/10.1590/S1679-45082010RB1416
Commodaro,A.G., Moraes,L.D.V. , Tambourgi,D.V., Belfort Jr.,R., Sant’Anna,O.A., & Rizzo,L.V. (2010). Autoimmune uveitis: study of treatment therapies. Einstein (Sao Paulo).,8(1), 117-121. https://doi.org/10.1590/S1679-45082010RB1416
Commodaro,Alessandra Gonçalves and Moraes,Luciana de Deus Vieira de and Tambourgi,Denise Vilarinho and Belfort Jr.,Rubens and Sant’Anna,Osvaldo Augusto and Rizzo,Luiz Vicente. Autoimmune uveitis: study of treatment therapies. Einstein (Sao Paulo). [online]. 2010, vol. 8, n. 1, [cited 2025-09-06], pp.117-121. Available from: <https://journal.einstein.br/article/autoimmune-uveitis-study-of-treatment-therapies/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082010RB1416
Figure 2
LMVp suppresses the clinical signs of actively induced EAU. B10.RIII mice were immunized with 100 µg of IRBP on day 0 and treated with 100 µg i.p. of LMVp 72 hours before immunization. Eyes were collected for histopathology 21 days after immunization. EAU scores were assigned on a scale from 0 to 4, according to the extent of inflammation and tissue damage.
LMVp suppresses the clinical signs of actively induced EAU. B10.RIII mice were immunized with 100 µg of IRBP on day 0 and treated with 100 µg i.p. of LMVp 72 hours before immunization. Eyes were collected for histopathology 21 days after immunization. EAU scores were assigned on a scale from 0 to 4, according to the extent of inflammation and tissue damage.