08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/Aug/2025;23:eAO1601.
View Article08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Keywords: Biomarkers; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Lymph nodes; Prognosis; Prostatic neoplasms
08/Aug/2025
Multifocal papillary thyroid microcarcinomas: is the total tumor diameter associated with the tumor behavior? A retrospective cohort study
einstein (São Paulo). 08/Aug/2025;23:eAO1724.
View Article08/Aug/2025
Multifocal papillary thyroid microcarcinomas: is the total tumor diameter associated with the tumor behavior? A retrospective cohort study
DOI: 10.31744/einstein_journal/2025AO1724
Highlights ■ In multifocal papillary thyroid microcarcinomas: ■ The total tumor diameter was not associated with aggressiveness or initial evolution. ■ Other factors are associated with disease outcomes. ■ The number of metastatic lymph nodes is an independent predictor of American Joint Committee on Cancer stage. ABSTRACT Objective: To evaluate whether the total tumor diameter (sum of the largest diameters of all foci) predicts tumor aggressiveness at initial presentation and treatment response at 1-year follow-up in patients with multifocal papillary […]
Keywords: Lymph node excision; Lymph nodes; Lymphatic metastasis; Neoplastic processes; Papillary thyroid microcarcinoma; Thyroglobulin
05/Jul/2023
Metastatic diffuse follicular variant papillary thyroid cancer without cervical lymph node metastasis presenting with symptoms related to hypopituitarism
einstein (São Paulo). 05/Jul/2023;21:eRC0229.
View Article05/Jul/2023
Metastatic diffuse follicular variant papillary thyroid cancer without cervical lymph node metastasis presenting with symptoms related to hypopituitarism
DOI: 10.31744/einstein_journal/2023RC0229
ABSTRACT In this article, we present a case of diffuse follicular variant papillary thyroid carcinoma with pituitary metastasis, which is a rare cause of pituitary metastasis. The follicular variant of papillary thyroid carcinoma is an uncommon variant of papillary carcinoma. A 74-year-old male was presented with weakness, fatigue, and a decreased appetite. The patient was diagnosed with secondary adrenal and thyroid insufficiencies. Imaging revealed a pituitary mass with suprasellar extension, right cavernous sinus invasion, and optic chiasm compression. Thyroid ultrasonography […]
Keywords: Hypopituitarism; Lymph nodes; Neoplasm metastasis; Pituitary neoplasms; Thyroid cancer, papillary; Thyroid neoplasms
06/May/2022
Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer
DOI: 10.31744/einstein_journal/2022AO6599
ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 91 patients diagnosed with prostate cancer between 2016 to 2020, who underwent 68Ga-PSMA PET-CT or PET-MRI for staging before prostatectomy. The patients were divided into Group 1, with 65 patients with satisfactory pathological lymph node analysis, and Group 2, with 91 patients representing the […]
Keywords: Data accuracy; Gallium; Lymph nodes; Positron emission tomography computed tomography; Prostate-specific antigen; Prostatectomy; Prostatic neoplasms
27/Nov/2019
Echoendoscopy with elastography in mediastinal lymph nodes
DOI: 10.31744/einstein_journal/2019MD5157
ABSTRACT Elastography is a widely used procedure in conventional ultrasonography that has recently been incorporated in echoendoscopy. This is an innovative and promising technology that aims to increase the negative predictive value of endoscopic ultrasonography and fine-needle aspiration punctures. It is useful for directing punctures in suspect areas and, consequently, improves diagnostic performance. This is a non-invasive technique, easy to perform, without additional costs or complications. The main indications are the analysis of solid pancreatic masses, lymph nodes, subepithelial lesions, […]
Keywords: Biopsy, fine-needle; Bronchoscopy; Endoscopic ultrasound-guided fine needle aspiration/methods; Lymph nodes; Mediastinum; Ultrasonography, interventional
30/Aug/2019
Endobronchial ultrasound: a minimally invasive technology to assist diagnosis of thoracic diseases
DOI: 10.31744/einstein_journal/2019MD4921
ABSTRACT The endobronchial ultrasound is a minimally invasive technique that simultaneously associates ultrasound and bronchoscopy, to visualize lung nodule or masses, airway wall, and structures adjacent to the tracheobronchial tree. Endobronchial ultrasound has been incorporated into clinical practice all over the world because of its low risk and high diagnostic yield in neoplastic and non-neoplastic disease.
Keywords: Biopsy, fine-needle; Bronchoscopy; Endoscopic ultrasound-guided fine needle aspiration/methods; Lymph nodes; Mediastinum; Ultrasonography, interventional
03/May/2018
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosis of mediastinal lesions
DOI: 10.1590/S1679-45082018AO4094
ABSTRACT Objective To describe the results of endobronchial ultrasound-guided transbronchial needle aspiration in making diagnosis of mediastinal injuries associated to different causes. Methods A retrospective cross-sectional study of patients submitted to Endobronchial ultrasound-guided transbronchial needle aspiration at a private organization, between June 2013 and October 2016. All cases referred for collection of lymph nodes or peritracheal/peribronchial masses by endobronchial ultrasound-guided transbronchial needle aspiration, and evaluated through tomography or PET-CT were included. Interventional pulmonologists and thoracic surgeons with experience in the […]
Keywords: Biopsy, fine-needle; Bronchoscopy; Endoscopic ultrasound-guided fine needle aspiration/methods; Lymph nodes; Mediastinum; Ultrasonography, interventional
08/Dec/2017
Translation and adaptation to Brazilian Portuguese of the Lymphedema Rating Scale in Head and Neck Cancer
DOI: 10.1590/S1679-45082017AO3995
ABSTRACT Objective: Translate to brazilian portuguese, culturally adapt and test the rating and classification scales of cervicofacial lymphedema of the MD Anderson Cancer Center Head and Neck Lymphedema Protocol (MDACC HNL) in patients undergoing treatment for head and neck cancer. Methods: The process followed international guidelines and translation stages by two head and neck surgeons, and back translation independently by two native Americans. The test of final version was based on the evaluation of 18 patients by one speech pathologist […]
Keywords: Head and neck neoplasms; Lymph nodes; Lymphedema; Neck dissection; Radiotherapy; Validation Studies
01/Apr/2010
Indications of Sentinel Node Biopsy in Thin Melanoma
DOI: 10.1590/S1679-45082010RW1424
ABSTRACT Objective: To assess data on survival, recurrence and histological factors in positive and negative sentinel lymph nodes in thin melanoma cases. Methods: A systematic review was conducted on observational studies in four databases (Cochrane Library, Medline, Embase and Lilacs). Positive and negative micrometastases in sentinel lymph node biopsy were compared regarding the clinical outcomes – death and recurrence – and six histological factors – vertical growth phase, Breslow thickness, Clark level, ulceration, regression and mitosis rate. Results: Positive sentinel […]
Keywords: Lymph nodes; Melanoma; Sentinel lymph node biopsy