Highlights ■ Remaining obese over time was independently associated with higher odds of depression. ABSTRACT Objective: To evaluate the association between longitudinal self-initiated changes in body mass index patterns and depression in a large sample of adults and older individuals. Methods: Participants included 1,944 adults and older individuals with depressive symptoms at baseline who underwent routine health screening examinations. Depression was defined as Beck Depression Inventory-II scores ≥14. Body mass index, blood pressure, blood samples, alcohol consumption, smoking status, physical […]