einstein (São Paulo). 06/Feb/2019;17(1):eAO4396.

Effective vancomycin concentrations in children: a cross-sectional study

Geisa Cristina da Silva Alves ORCID logo , Farah Maria Drumond Chequer ORCID logo , Cristina Sanches ORCID logo

DOI: 10.31744/einstein_journal/2019AO4396

ABSTRACT

Objective

Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment.

Methods

This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour interval between each withdrawal.

Results

Ten pediatric patients with median age of 5.5 years and interquartile range (IQR) of 3.2-9.0 years, median weight of 21kg (IQR: 15.5-24.0kg) and median height of 112.5cm (IQR: 95-133cm), were included. Only one child achieved trough concentrations between 10µg/mL and 15µg/mL.

Conclusion

The empirical use of vancomycin in the children studied did not achieve the therapeutic pharmacokinetic/pharmacodynamic target for minimum inhibitory concentration of 1µg/mL.

Effective vancomycin concentrations in children: a cross-sectional study

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