2 results
27/Aug/2019
DOI: 10.31744/einstein_journal/2019AO4637
ABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration […]
Keywords: Biomarkers; Glycosaminoglycans; Intervertebral disc degeneration; Proteoglycans
01/Oct/2015
01/Oct/2015
DOI: 10.1590/S1679-45082015AO3477
ABSTRACT Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression. Methods Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metastases. Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by electrospray ionization mass spectrometry, with the technique for extraction and quantification […]
Keywords: Chondroitin; Colorectal neoplasms; Dermatan sulfate; Extracellular matrix; Glycosaminoglycans; Heparitin sulfate; Proteoglycans; Spectrometry, mass, electrospray ionization