einstein (São Paulo). 27/Aug/2019;17(4):eAO4637.

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

Luciano Miller Reis Rodrigues ORCID logo , Lilian Zerbinatti de Oliveira ORCID logo , Mariane de Barros Ribeiro da Silva ORCID logo , Camila de Melo Accardo ORCID logo , Adriana Braz Del Giglio ORCID logo , Maria Aparecida da Silva Pinhal ORCID logo

DOI: 10.31744/einstein_journal/2019AO4637

ABSTRACT

Objective:

To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers.

Methods:

We conducted immunohistochemistry studies of intervertebral discs to analyze interleukin 6 and cathepsin B levels of patients with degenerative disease and spine fracture (Control Group) and to measure hyaluronic acid, interleukin 6 and cathepsin B activity from sera of intervertebral disc degeneration patients, fracture patients, and healthy individuals.

Results:

Interleukin 6 and cathepsin B seem to be related with physiopathology of intervertebral disc degeneration, since the levels of both were higher in discs of patients with intervertebral disc degeneration. Interleukin 6 and cathepsin B do not represent good biomarkers of degenerative intervertebral disc disease, since the level of such compounds is increased in the plasma of patients with fractures.

Conclusion:

Hyaluronic acid can be a biomarker for intervertebral disc degeneration, because hyaluronic acid levels were higher only in sera of patients with intervertebral disc degeneration.

Inflammatory biomarkers in sera of patients with intervertebral disc degeneration

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