19/Aug/2025
Overall and disease-free survival in patients with HPV-positive and HPV-negative oropharyngeal cancer
DOI: 10.31744/einstein_journal/2025AO1525
Highlights ■ HPV+ is associated with improved overall survival in oropharyngeal cancer ■ HPV+ tumors tend to recur earlier than HPV- tumors. ■ Metastasis is a key prognostic factor for mortality and recurrence regardless of HPV status. ■ Smoking and alcohol consumption reduce the favorable prognosis of HPV+. ABSTRACT Objective: To analyze the overall and disease-free survival of patients with oropharyngeal squamous cell carcinoma. Methods: Sociodemographic and clinical data, HPV status, and alcohol/tobacco consumption were assessed among patients treated at […]
Keywords: Disease-free survival; Human papillomavirus viruses; Oropharyngeal neoplasms; Prognosis; Recurrence; Squamous cell carcinoma of head and neck; Survival rate
08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/Aug/2025;23:eAO1601.
View Article08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Keywords: Biomarkers; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Lymph nodes; Prognosis; Prostatic neoplasms
25/Sep/2024
Acute kidney injury in coronavirus disease: a comparative study of the two waves in Brazil
DOI: 10.31744/einstein_journal/2024AO0687
ABSTRACT Highlights Renal involvement was frequent in patients with COVID-19 and related to worse outcomes. Diuretic use, mechanical ventilation, proteinuria, hematuria, age, and creatine phosphokinase and D-dimer levels were risk factors for acute kidney injury. Acute kidney injury, mechanical ventilation, elevated SOFA Score, and elevated ATN-ISS were associated with mortality. The second wave was associated with greater severity; however, the mortality rates were similar between the two periods. This may reflect the effectiveness of vaccines and the constant learning that […]
Keywords: Acute kidney injury; Brazil; Coronavirus infections; COVID-19; Incidence; Mortality; Prognosis; Receptor cross-talk
07/Mar/2023
Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?
einstein (São Paulo). 07/Mar/2023;31:eAO0172.
View Article07/Mar/2023
Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?
DOI: 10.31744/einstein_journal/2023AO0172
Highlights Patients at nutritional risk had a lower survival than those not at nutritional risk. Nutritional risk had good discriminatory accuracy to predict death. Nutritional screening should be included as an essential part of care for these patients. ABSTRACT Objective To verify whether the presence of related nutritional risk indicators prior to COVID-19 diagnosis is associated with poor survival in patients with cancer. Methods We retrospectively analyzed the data of hospitalized cancer patients who tested positive for COVID-19 between […]
Keywords: Coronavirus; Coronavirus infections; COVID-19; Malnutrition; Neoplasms; Nutritional status; Prognosis
19/Dec/2022
Molecular profile of patients with myelofibrosis: a 10-year experience
DOI: 10.31744/einstein_journal/2023AO0100
Highlights Karyotype was normal in 60% of patients and altered in 40%. The variants most often detected in the myeloid panel were: JAK2 (54%), ASXL1 (50%), TET2 (31%), and CALR (22%). The median follow-up of transplant patients was 2.4 years and the two-year overall survival was 80%. ABSTRACT Objective To analyze the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and to compare transplant characteristics in patients referred for bone marrow transplantation. Methods Retrospective, […]
Keywords: Bone marrow transplantation; Cytogenetic analysis; Mutation; Primary myelofibrosis; Prognosis
20/May/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
einstein (São Paulo). 20/May/2022;20:eAO6953.
View Article20/May/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
DOI: 10.31744/einstein_journal/2022AO6953
ABSTRACT Objective: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. Methods: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data […]
Keywords: Coronavirus infections; COVID-19; Multidetector computed tomography; Obesity; Pneumonia; Prognosis; Tomography; X-ray computed
15/Dec/2021
The delay of breast cancer diagnosis during the COVID-19 pandemic in São Paulo, Brazil
DOI: 10.31744/einstein_journal/2021AO6721
ABSTRACT Objective To evaluate the impact of COVID-19 pandemic on breast cancer diagnosis in a breast imaging center. Methods This was a retrospective cohort study that included women submitted to breast exams and procedures in a private hospital in São Paulo, SP, Brazil, as from the period of most strict social isolation measures, in 2020 (separated in first period of social isolation, March 24 to June 21, 2020, and second period, June 22 to December 31, 2020), as compared to […]
Keywords: Brazil; Breast cancer screening; Breast neoplasms; Coronavirus infections; Early detection of cancer; Magnetic resonance spectroscopy; Mammography; Prognosis; Ultrasonography, mammary
14/Nov/2019
Neutrophil-lymphocyte ratio change after curative gastrectomy for gastric cancer: a subgroup analysis
DOI: 10.31744/einstein_journal/2020AO4860
ABSTRACT Objective: To evaluate the impact of neutrophil-lymphocyte ratio change after curative surgery for gastric cancer. Methods: A retrospective analysis of patients with gastric cancer who underwent curative surgery between 2009 and 2017 was performed. A cutoff value was established for the neutrophil-lymphocyte ratio in the pre- and postoperative periods, according to the median value, and four subgroups were formed (low-low/low-high/high-low/high-high). Clinical-pathological and survival data were analyzed and related to these subgroups. Results: A total of 325 patients were included […]
Keywords: Biomarkers; Gastrectomy; Inflammation; Prognosis; Stomach neoplasms
17/Jan/2019
Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer
einstein (São Paulo). 17/Jan/2019;17(1):eAO3434.
View Article17/Jan/2019
Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer
DOI: 10.31744/einstein_journal/2019AO3434
ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type […]
Keywords: Breast neoplasms/pathology; Neoadjuvant therapy; Predictive value of tests; Prognosis; Survivorship (Public Health)
04/Jul/2018
Oral and oropharyngeal cancer: epidemiology and survival analysis
DOI: 10.1590/S1679-45082018AO4248
ABSTRACT Objective To evaluate the epidemiological profile and survival rate of oral and oropharyngeal cancer patients seen at a university hospital. Methods A cross-sectional study was carried out by means of the pathological reports of patients with oral and oropharyngeal cancer, seen at a university hospital of the Southern Region, between January 2004 and December 2014. Information was collected on patients and tumors. The mortality rate was gathered from the patient death registry in the Mortality Information System. Data were […]
Keywords: Mouth neoplasms/epidemiology; Oropharyngeal neoplasms/epidemiology; Prognosis; Survival rate