2 results

Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation

Isabella Caroline Pereira Rodrigues ORCID logo , Andreas Kaasi ORCID logo , Rubens Maciel Filho ORCID logo , André Luiz Jardini ORCID logo , Laís Pellizzer Gabriel ORCID logo

DOI: 10.1590/S1679-45082018RB4538

ABSTRACT Cardiovascular diseases are the major cause of death worldwide. The heart has limited capacity of regeneration, therefore, transplantation is the only solution in some cases despite presenting many disadvantages. Tissue engineering has been considered the ideal strategy for regenerative medicine in cardiology. It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues […]

Heart transplantation: review

Sandrigo Mangini, Bárbara Rubim Alves, Odílson Marcos Silvestre, Philippe Vieira Pires, Lucas José Tachotti Pires, Milena Novaes Cardoso Curiati, [...]

DOI: 10.1590/S1679-45082015RW3154

ABSTRACTHeart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rejection through defined protocols of immunosuppression, the outcomes of heart transplantation are very favorable. Among early complications that can impact survival are primary graft failure, […]