05/Jun/2025
Incidentally detected breast lesions: a pictorial essay of malignant and benign findings
DOI: 10.31744/einstein_journal/2025RW0681
ABSTRACT Incidentalomas are lesions incidentally identified in patients undergoing imaging for unrelated reasons. Breast incidentalomas have a high correlation with malignancy, occurring in over 40% of cases. Consequently, their interpretation poses significant challenges for radiologists who must discern the findings that may present a potential risk to the patient. This pictorial review presents different incidental breast lesions revealed through cross-sectional imaging. We further review key concepts related to such incidentalomas.
Keywords: Breast neoplasms; Diagnostic imaging; Incidental findings; Incidentalomas; Positron emission tomography computed tomography; Tomography, x-ray computed
28/Apr/2025
Omission of dexamethasone in prophylaxis for highly emetogenic chemotherapy in patients with breast cancer
DOI: 10.31744/einstein_journal/2025AO1124
Highlights ■ Evaluation of a corticosteroid-free antiemetic regimen. ■ Primary endpoint: 46% nausea control. ■ Secondary endpoint: 68% emesis control. ■ Comparable to standard four-drug protocols. ABSTRACT Objective: Chemotherapy-induced nausea and vomiting are highly prevalent adverse events that can lead to poor treatment adherence and a decreased quality of life. To the best of our knowledge, the complete omission of dexamethasone from any regimen for preventing nausea and vomiting has not yet been evaluated. This study aimed to evaluate the […]
Keywords: Antineoplastic agents; Breast neoplasms; Dexamethasone; Drug therapy; Drug-related side effects and adverse reactions; Nausea; Olanzapine; Vomiting
07/Apr/2025
A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina
einstein (São Paulo). 07/Apr/2025;23:eAO1237.
View Article07/Apr/2025
A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina
DOI: 10.31744/einstein_journal/2025AO1237
Highlights ■ No clinically significant differences were observed in platelet counts or global coagulation test results. ■ t-PA values decreased in patients with metastases. ■ PAI-1, DD, and MMP-9 levels increased in patients with metastases. ■ High levels of PAI-1 and MMP-9 in the early stages could indicate an aggressive course in patients. ABSTRACT Objective: The hemostatic and matrix metalloproteinase (MMP) systems are known to be altered in patients with breast cancer. This cross-sectional study aimed to explore the fibrinolysis […]
Keywords: Breast disease; Breast neoplasms; Fibrinolysis; Matrix metalloproteinase; Metastasis neoplasms; Plasminogen activator inhibitor 1; Standard coagulation tests
28/Mar/2025
Brazil’s benign breast disease care profile and geospatial analysis
DOI: 10.31744/einstein_journal/2025AO1132
Highlights ■ Most outpatient consultations comprised diagnostic procedures. ■ In the past 12 years, medical care for benign breast diseases has cost >USD 65 million. ■ Women from North and Midwest Brazil had higher diagnosis and treatment displacement rates. ABSTRACT Objective: To quantitatively and geospatially analyze coverage and displacement for the diagnosis and treatment of benign breast diseases in the Brazilian Unified Health System between 2008 and 2019. Methods: Datasets from the Brazilian Ministry of Health were used to survey […]
Keywords: Brazil; Breast diseases; Breast neoplasms; Demography; Epidemiology; Health expenditures; Healthcare costs; Hospitalization; Incidence; Primary healthcare; Public health; Strategy planning; Unified Health System
07/Oct/2024
Knowledge related to breast cancer screening programs by physicians in Brazil
DOI: 10.31744/einstein_journal/2024AO0760
Highlights Variability in screening protocols: only 42.8% of gynecologists and obstetricians follow the 40-74 years protocol, while 76.6% of family physicians follow the 50-69 years protocol. High rate of incorrect BIRADS™ interpretation: there were 46.3% incorrect responses among gynecologists and obstetricians and 77.9% among family physicians, highlighting significant knowledge gaps. Misconception about breast ultrasound: 39.1% of gynecologists and obstetricians and 20.3% of family physicians incorrectly consider ultrasound as a screening method. Impact of inadequate training: inadequate training leads to improper […]
Keywords: attitudes; Brazil; Breast neoplasms; Family; Gynecologists; Health knowledge; Mammography; Mass screening; Obstetricians; Physicians; practice; Preventive medicine; Surveys and questionnaires
14/Mar/2024
Quality of life of women who underwent breast cancer treatment relative to sociodemographic, behavioral, and clinical factors
einstein (São Paulo). 14/Mar/2024;22:eAO0585.
View Article14/Mar/2024
Quality of life of women who underwent breast cancer treatment relative to sociodemographic, behavioral, and clinical factors
DOI: 10.31744/einstein_journal/2024AO0585
Highlights Sociodemographic, clinical, and lifestyle factors impact the quality of life of breast cancer survivors. Breast cancer therapy may affect future perspectives and emotional, cognitive, and sexual function. Some aspects of quality of life still require attention from health professionals. ABSTRACT Objective: Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, […]
Keywords: Activities of Daily Living; Breast neoplasms; Life style; Quality of life; Sociodemographic factors; Surveys and questionnaires
Febrile neutropenia incidence and the variable toxicity profile between brand and generic docetaxel in the adjuvant treatment of breast cancer with docetaxel and cyclophosphamide regimen

19/Dec/2023
Febrile neutropenia incidence and the variable toxicity profile between brand and generic docetaxel in the adjuvant treatment of breast cancer with docetaxel and cyclophosphamide regimen
einstein (São Paulo). 19/Dec/2023;21:eAO0486.
View Article19/Dec/2023
Febrile neutropenia incidence and the variable toxicity profile between brand and generic docetaxel in the adjuvant treatment of breast cancer with docetaxel and cyclophosphamide regimen
DOI: 10.31744/einstein_journal/2023AO0486
Highlights The overall incidence of febrile neutropenia in the study population was 13.4% (31 cases) Brand-name docetaxel (Taxotere®) use was the only factor associated with the occurrence of febrile neutropenia. No statistically significant differences in progression-free survival rates between brand-name and generic docetaxel. ABSTRACT Objective: To assess the incidence of febrile neutropenia without primary granulocyte colonystimulating factor prophylaxis in patients undergoing chemotherapy with adjuvant docetaxel and cyclophosphamide, and to evaluate the toxicity profile of brand-name docetaxel (Taxotere®) and the generic […]
Keywords: Breast neoplasms; Cyclophosphamide; Docetaxel; Drugs, generic; Febrile neutropenia; Granulocyte colony-stimulating factor
10/Nov/2023
Phenocopy in a patient with triple negative breast cancer: a case report
DOI: 10.31744/einstein_journal/2023RC0319
ABSTRACT A total of 1.67 million breast cancer cases per year are reported worldwide. Of these, 5%–10% are caused by inherited mutations. Phenocopy is a rare phenomenon, with only a few cases reported in the literature. In phenocopies, phenotypes identical to those with genetic origin occur because of environmental factors rather than familial mutations. We describe a case of phenocopy in a 44-year-old female patient with triple-negative breast cancer. The mother and sister wee heterozygous for c.1813delA, p.Ile605TyrfsTer9 in BRCA2 […]
Keywords: Breast neoplasms; Genes BRCA1; Genes BRCA2; Genetic predisposition to disease; Mutation; Phenotype
06/Jun/2023
Is physical inactivity and sedentary behavior associated with tumor stage in breast cancer patients? A cross-sectional study of Brazilian women
einstein (São Paulo). 06/Jun/2023;21:eAO0215.
View Article06/Jun/2023
Is physical inactivity and sedentary behavior associated with tumor stage in breast cancer patients? A cross-sectional study of Brazilian women
DOI: 10.31744/einstein_journal/2023AO0215
Highlights ■ Physical activity level is associated with responsiveness to hormones in women with breast cancer. ■ Sedentary behavior is significantly related to the histological tumor grade in women with breast cancer. ABSTRACT Objective A comparative analysis of the association between sedentary behavior versus physical activity levels and tumor staging in women with breast cancer. Methods The present research adopted a cross-sectional study design to recruit a total of 55 adult and elderly women newly diagnosed with breast cancer for […]
Keywords: Breast neoplasms; Exercise; Neoplasm staging; Sedentary behavior; Sitting position
02/May/2022
Cost-effectiveness analysis of Ado-trastuzumab emtansine for the treatment of residual invasive HER2-positive breast cancer
einstein (São Paulo). 02/May/2022;20:eGS6655.
View Article02/May/2022
Cost-effectiveness analysis of Ado-trastuzumab emtansine for the treatment of residual invasive HER2-positive breast cancer
DOI: 10.31744/einstein_journal/2022GS6655
ABSTRACT Objective Human epidermal growth factor receptor 2 (HER2) overexpression occurs in up to 30% of breast cancer cases. Ado-trastuzumab emtansine (T-DM1) is approved to treat residual HER2-positive breast cancer after neoadjuvant therapy. The aim of this study was to determine the quality-adjusted time with symptoms or toxicity and without symptoms or toxicity (Q-TWiST) of T-DM1 compared to trastuzumab for residual invasive HER2-positive breast cancer. Methods The authors developed an analytical model extracting individual patient data and estimated invasive disease-free […]
Keywords: Ado-trastuzumab emtansine; Breast neoplasms; Cost-benefit analysis; HER2-positive; Neoplasm, residual