einstein (São Paulo). 30/Oct/2018;16(4):eAO4199.

Helium-oxygen mixture: clinical applicability in an intensive care unit

Milena Siciliano Nascimento ORCID logo , Érica Santos ORCID logo , Cristiane do Prado ORCID logo

DOI: 10.31744/einstein_journal/2018AO4199



To evaluate if distress respiratory decreases after using helium-oxygen mixture in pediatric patients diagnosed with bronchospasm.


This is a retrospective, non-randomized study that included patients diagnosed with bronchospasm, who received a helium-oxygen mixture at three time points (30, 60, and 120 minutes) according to the organization protocol singular, and were admitted to the intensive care unit, from January 2012 to December 2013. This protocol includes patients with bronchospasm who sustained a modified Wood score of moderate to severe, even after one hour of conventional treatment.


Twenty children were included in the study. The mean score of severity of the disease at the initial moment was 5.6 (SD:2.0), and at moment 120 minutes, it was 3.4 (SD: 2.0). The severity score showed a significant improvement as of 30 minutes (p<0.001).


The use of helium-oxygen mixture proved to be effective in diminishing the respiratory distress score for children with airway obstructions; it should be considered a supplementary therapeutic option, together with drug therapy, in specific clinical situations.

Helium-oxygen mixture: clinical applicability in an intensive care unit